Identification of an albumin-like protein in plasma of Atlantic cod (Gadus morhua) and its biomarker potential for PAH contamination
Increased research efforts are currently focusing on Atlantic cod (Gadus morhua) and its significance for monitoring the contaminant situation in marine environments. Polycyclic aromatic hydrocarbons (PAHs) are well known toxic and carcinogenic compounds, thus continuous monitoring is required to en...
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ftpubmed:oai:pubmedcentral.nih.gov:5553345 2023-05-15T15:26:32+02:00 Identification of an albumin-like protein in plasma of Atlantic cod (Gadus morhua) and its biomarker potential for PAH contamination Enerstvedt, Karianne Skogland Sydnes, Magne O. Pampanin, Daniela M. 2017-08-10 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553345/ https://doi.org/10.1016/j.heliyon.2017.e00367 en eng Elsevier http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553345/ http://dx.doi.org/10.1016/j.heliyon.2017.e00367 © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). CC-BY-NC-ND Article Text 2017 ftpubmed https://doi.org/10.1016/j.heliyon.2017.e00367 2017-08-27T00:07:02Z Increased research efforts are currently focusing on Atlantic cod (Gadus morhua) and its significance for monitoring the contaminant situation in marine environments. Polycyclic aromatic hydrocarbons (PAHs) are well known toxic and carcinogenic compounds, thus continuous monitoring is required to ensure ecosystem sustainability and human food safety. A sensitive biomarker of PAH exposure in humans is the detection of PAH metabolites bound to albumin in blood. The potential of a similar PAH-albumin biomarker in Atlantic cod was therefore investigated by a desktop bioinformatic study followed by liquid chromatography mass spectrometry/mass spectrometry analysis of plasma from 16 fish. For the first time, an albumin-like protein in plasma of Atlantic cod is described, and the biomarker potential based on PAH-albumin adduct detection is discussed. Due to the detected low abundance of the albumin-like protein, it was found unlikely to be applicable as a new biomarker tool for evaluation of PAH exposure. Text atlantic cod Gadus morhua PubMed Central (PMC) Heliyon 3 8 e00367 |
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Article Enerstvedt, Karianne Skogland Sydnes, Magne O. Pampanin, Daniela M. Identification of an albumin-like protein in plasma of Atlantic cod (Gadus morhua) and its biomarker potential for PAH contamination |
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description |
Increased research efforts are currently focusing on Atlantic cod (Gadus morhua) and its significance for monitoring the contaminant situation in marine environments. Polycyclic aromatic hydrocarbons (PAHs) are well known toxic and carcinogenic compounds, thus continuous monitoring is required to ensure ecosystem sustainability and human food safety. A sensitive biomarker of PAH exposure in humans is the detection of PAH metabolites bound to albumin in blood. The potential of a similar PAH-albumin biomarker in Atlantic cod was therefore investigated by a desktop bioinformatic study followed by liquid chromatography mass spectrometry/mass spectrometry analysis of plasma from 16 fish. For the first time, an albumin-like protein in plasma of Atlantic cod is described, and the biomarker potential based on PAH-albumin adduct detection is discussed. Due to the detected low abundance of the albumin-like protein, it was found unlikely to be applicable as a new biomarker tool for evaluation of PAH exposure. |
format |
Text |
author |
Enerstvedt, Karianne Skogland Sydnes, Magne O. Pampanin, Daniela M. |
author_facet |
Enerstvedt, Karianne Skogland Sydnes, Magne O. Pampanin, Daniela M. |
author_sort |
Enerstvedt, Karianne Skogland |
title |
Identification of an albumin-like protein in plasma of Atlantic cod (Gadus morhua) and its biomarker potential for PAH contamination |
title_short |
Identification of an albumin-like protein in plasma of Atlantic cod (Gadus morhua) and its biomarker potential for PAH contamination |
title_full |
Identification of an albumin-like protein in plasma of Atlantic cod (Gadus morhua) and its biomarker potential for PAH contamination |
title_fullStr |
Identification of an albumin-like protein in plasma of Atlantic cod (Gadus morhua) and its biomarker potential for PAH contamination |
title_full_unstemmed |
Identification of an albumin-like protein in plasma of Atlantic cod (Gadus morhua) and its biomarker potential for PAH contamination |
title_sort |
identification of an albumin-like protein in plasma of atlantic cod (gadus morhua) and its biomarker potential for pah contamination |
publisher |
Elsevier |
publishDate |
2017 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553345/ https://doi.org/10.1016/j.heliyon.2017.e00367 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553345/ http://dx.doi.org/10.1016/j.heliyon.2017.e00367 |
op_rights |
© 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.heliyon.2017.e00367 |
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e00367 |
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1766357006523826176 |