Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia
Aquatic mammals, such as cetaceans experience various depths, with accordingly diverse oxygenation, thus, cetaceans have developed adaptations for hypoxia, but mechanisms underlying this tolerance to low oxygen are unclear. Here we analyzed VHL and HIF-2α, in the hypoxia signaling pathway. Variation...
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ftpubmed:oai:pubmedcentral.nih.gov:5522066 2023-05-15T15:41:42+02:00 Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia Bi, Jianling Hu, Bo Wang, Jing Liu, Xing Zheng, Jinsong Wang, Ding Xiao, Wuhan 2017-02-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522066/ http://www.ncbi.nlm.nih.gov/pubmed/28178687 https://doi.org/10.18632/oncotarget.15038 en eng Impact Journals LLC http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522066/ http://www.ncbi.nlm.nih.gov/pubmed/28178687 http://dx.doi.org/10.18632/oncotarget.15038 Copyright: © 2017 Bi et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. CC-BY Research Paper Text 2017 ftpubmed https://doi.org/10.18632/oncotarget.15038 2017-08-13T00:05:39Z Aquatic mammals, such as cetaceans experience various depths, with accordingly diverse oxygenation, thus, cetaceans have developed adaptations for hypoxia, but mechanisms underlying this tolerance to low oxygen are unclear. Here we analyzed VHL and HIF-2α, in the hypoxia signaling pathway. Variations in VHL are greater than HIF-2α between cetaceans and terrestrial mammals, and beluga whale VHL (BW-VHL) promotes HIF-2α degradation under hypoxia. BW-VHL catalyzes BW-HIF-2α to form K48-linked poly-ubiquitin chains mainly at the lysine 429 of BW-HIF-2α (K429) and induces BW-HIF-2α for proteasomal degradation. W100 within BW-VHL is a key site for BW-VHL functionally and BW-VHL enhances transcriptional activity of BW-HIF-2α under hypoxia. Our data therefore reveal that BW-VHL has a unique function that may contribute to hypoxic adaptation. Text Beluga Beluga whale Beluga* PubMed Central (PMC) Oncotarget 8 26 42272 42287 |
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Research Paper Bi, Jianling Hu, Bo Wang, Jing Liu, Xing Zheng, Jinsong Wang, Ding Xiao, Wuhan Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia |
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Research Paper |
description |
Aquatic mammals, such as cetaceans experience various depths, with accordingly diverse oxygenation, thus, cetaceans have developed adaptations for hypoxia, but mechanisms underlying this tolerance to low oxygen are unclear. Here we analyzed VHL and HIF-2α, in the hypoxia signaling pathway. Variations in VHL are greater than HIF-2α between cetaceans and terrestrial mammals, and beluga whale VHL (BW-VHL) promotes HIF-2α degradation under hypoxia. BW-VHL catalyzes BW-HIF-2α to form K48-linked poly-ubiquitin chains mainly at the lysine 429 of BW-HIF-2α (K429) and induces BW-HIF-2α for proteasomal degradation. W100 within BW-VHL is a key site for BW-VHL functionally and BW-VHL enhances transcriptional activity of BW-HIF-2α under hypoxia. Our data therefore reveal that BW-VHL has a unique function that may contribute to hypoxic adaptation. |
format |
Text |
author |
Bi, Jianling Hu, Bo Wang, Jing Liu, Xing Zheng, Jinsong Wang, Ding Xiao, Wuhan |
author_facet |
Bi, Jianling Hu, Bo Wang, Jing Liu, Xing Zheng, Jinsong Wang, Ding Xiao, Wuhan |
author_sort |
Bi, Jianling |
title |
Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia |
title_short |
Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia |
title_full |
Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia |
title_fullStr |
Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia |
title_full_unstemmed |
Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia |
title_sort |
beluga whale pvhl enhances hif-2α activity via inducing hif-2α proteasomal degradation under hypoxia |
publisher |
Impact Journals LLC |
publishDate |
2017 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522066/ http://www.ncbi.nlm.nih.gov/pubmed/28178687 https://doi.org/10.18632/oncotarget.15038 |
genre |
Beluga Beluga whale Beluga* |
genre_facet |
Beluga Beluga whale Beluga* |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522066/ http://www.ncbi.nlm.nih.gov/pubmed/28178687 http://dx.doi.org/10.18632/oncotarget.15038 |
op_rights |
Copyright: © 2017 Bi et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
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CC-BY |
op_doi |
https://doi.org/10.18632/oncotarget.15038 |
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Oncotarget |
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8 |
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26 |
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42272 |
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42287 |
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1766374599653588992 |