No evidence for MHC class II-based non-random mating at the gametic haplotype in Atlantic salmon
Genes of the major histocompatibility complex (MHC) are a likely target of mate choice because of their role in inbreeding avoidance and potential benefits for offspring immunocompetence. Evidence for female choice for complementary MHC alleles among competing males exists both for the pre- and the...
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ftpubmed:oai:pubmedcentral.nih.gov:5436021 2023-05-15T15:30:45+02:00 No evidence for MHC class II-based non-random mating at the gametic haplotype in Atlantic salmon Promerová, M Alavioon, G Tusso, S Burri, R Immler, S 2017-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436021/ http://www.ncbi.nlm.nih.gov/pubmed/28098849 https://doi.org/10.1038/hdy.2016.129 en eng Nature Publishing Group http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436021/ http://www.ncbi.nlm.nih.gov/pubmed/28098849 http://dx.doi.org/10.1038/hdy.2016.129 Copyright © 2017 The Genetics Society Macmillan Publishers Limited, part of Springer Nature. Original Article Text 2017 ftpubmed https://doi.org/10.1038/hdy.2016.129 2018-06-03T00:08:32Z Genes of the major histocompatibility complex (MHC) are a likely target of mate choice because of their role in inbreeding avoidance and potential benefits for offspring immunocompetence. Evidence for female choice for complementary MHC alleles among competing males exists both for the pre- and the postmating stages. However, it remains unclear whether the latter may involve non-random fusion of gametes depending on gametic haplotypes resulting in transmission ratio distortion or non-random sequence divergence among fused gametes. We tested whether non-random gametic fusion of MHC-II haplotypes occurs in Atlantic salmon Salmo salar. We performed in vitro fertilizations that excluded interindividual sperm competition using a split family design with large clutch sample sizes to test for a possible role of the gametic haplotype in mate choice. We sequenced two MHC-II loci in 50 embryos per clutch to assess allelic frequencies and sequence divergence. We found no evidence for transmission ratio distortion at two linked MHC-II loci, nor for non-random gamete fusion with respect to MHC-II alleles. Our findings suggest that the gametic MHC-II haplotypes play no role in gamete association in Atlantic salmon and that earlier findings of MHC-based mate choice most likely reflect choice among diploid genotypes. We discuss possible explanations for these findings and how they differ from findings in mammals. Text Atlantic salmon Salmo salar PubMed Central (PMC) Heredity 118 6 563 567 |
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Original Article Promerová, M Alavioon, G Tusso, S Burri, R Immler, S No evidence for MHC class II-based non-random mating at the gametic haplotype in Atlantic salmon |
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Original Article |
description |
Genes of the major histocompatibility complex (MHC) are a likely target of mate choice because of their role in inbreeding avoidance and potential benefits for offspring immunocompetence. Evidence for female choice for complementary MHC alleles among competing males exists both for the pre- and the postmating stages. However, it remains unclear whether the latter may involve non-random fusion of gametes depending on gametic haplotypes resulting in transmission ratio distortion or non-random sequence divergence among fused gametes. We tested whether non-random gametic fusion of MHC-II haplotypes occurs in Atlantic salmon Salmo salar. We performed in vitro fertilizations that excluded interindividual sperm competition using a split family design with large clutch sample sizes to test for a possible role of the gametic haplotype in mate choice. We sequenced two MHC-II loci in 50 embryos per clutch to assess allelic frequencies and sequence divergence. We found no evidence for transmission ratio distortion at two linked MHC-II loci, nor for non-random gamete fusion with respect to MHC-II alleles. Our findings suggest that the gametic MHC-II haplotypes play no role in gamete association in Atlantic salmon and that earlier findings of MHC-based mate choice most likely reflect choice among diploid genotypes. We discuss possible explanations for these findings and how they differ from findings in mammals. |
format |
Text |
author |
Promerová, M Alavioon, G Tusso, S Burri, R Immler, S |
author_facet |
Promerová, M Alavioon, G Tusso, S Burri, R Immler, S |
author_sort |
Promerová, M |
title |
No evidence for MHC class II-based non-random mating at the gametic haplotype in Atlantic salmon |
title_short |
No evidence for MHC class II-based non-random mating at the gametic haplotype in Atlantic salmon |
title_full |
No evidence for MHC class II-based non-random mating at the gametic haplotype in Atlantic salmon |
title_fullStr |
No evidence for MHC class II-based non-random mating at the gametic haplotype in Atlantic salmon |
title_full_unstemmed |
No evidence for MHC class II-based non-random mating at the gametic haplotype in Atlantic salmon |
title_sort |
no evidence for mhc class ii-based non-random mating at the gametic haplotype in atlantic salmon |
publisher |
Nature Publishing Group |
publishDate |
2017 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436021/ http://www.ncbi.nlm.nih.gov/pubmed/28098849 https://doi.org/10.1038/hdy.2016.129 |
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Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436021/ http://www.ncbi.nlm.nih.gov/pubmed/28098849 http://dx.doi.org/10.1038/hdy.2016.129 |
op_rights |
Copyright © 2017 The Genetics Society Macmillan Publishers Limited, part of Springer Nature. |
op_doi |
https://doi.org/10.1038/hdy.2016.129 |
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