Investigator Argus X-12 study on the population of northern Croatia
X chromosome STR typing has emerged recently as a powerful tool, complementary to autosomal STR typing, in solving complex forensic and missing person cases. Investigator® Argus X-12 is a commercial product that allows co-amplification of 12 X chromosomal markers belonging to four linkage groups (LG...
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Sociedade Brasileira de Genética
2016
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ftpubmed:oai:pubmedcentral.nih.gov:5409765 2023-05-15T16:31:11+02:00 Investigator Argus X-12 study on the population of northern Croatia Crnjac, Josip Ozretić, Petar Merkaš, Siniša Ratko, Martina Lozančić, Mateja Korolija, Marina Popović, Maja Mršić, Gordan 2016-10-20 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409765/ http://www.ncbi.nlm.nih.gov/pubmed/27768154 https://doi.org/10.1590/1678-4685-GMB-2015-0261 en eng Sociedade Brasileira de Genética http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409765/ http://www.ncbi.nlm.nih.gov/pubmed/27768154 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0261 Copyright © 2016, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited. CC-BY Human and Medical Genetics Text 2016 ftpubmed https://doi.org/10.1590/1678-4685-GMB-2015-0261 2017-05-14T00:06:22Z X chromosome STR typing has emerged recently as a powerful tool, complementary to autosomal STR typing, in solving complex forensic and missing person cases. Investigator® Argus X-12 is a commercial product that allows co-amplification of 12 X chromosomal markers belonging to four linkage groups (LGs). In this study, we analyzed by capillary electrophoresis blood samples from 100 females and 102 males from a population of northern Croatia. Statistical analysis included calculation of allele and haplotype frequencies, as well as forensic parameters. The most informative marker for the northern Croatia population was DXS10135 with PIC=0.9211 and a total of 27 alleles. The least polymorphic marker was DXS8378 with 6 alleles. The proportion of observed haplotypes from the number of possible haplotypes varied from 2.74–8.57% across all LGs, with LG1 being the most informative. Of the 11 tested world populations compared to the population of northern Croatia, significant differences in genetic distance (FST) were found for Greenlandic and all non-European populations. We found that all tested markers are in HWE and can thus be used for match probability calculation. Because of high combined power of discrimination in both men and women, Investigator® Argus X-12 is applicable for the northern Croatia population in routine forensic casework. Text greenlandic PubMed Central (PMC) Genetics and Molecular Biology 40 1 80 83 |
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Human and Medical Genetics |
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Human and Medical Genetics Crnjac, Josip Ozretić, Petar Merkaš, Siniša Ratko, Martina Lozančić, Mateja Korolija, Marina Popović, Maja Mršić, Gordan Investigator Argus X-12 study on the population of northern Croatia |
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Human and Medical Genetics |
description |
X chromosome STR typing has emerged recently as a powerful tool, complementary to autosomal STR typing, in solving complex forensic and missing person cases. Investigator® Argus X-12 is a commercial product that allows co-amplification of 12 X chromosomal markers belonging to four linkage groups (LGs). In this study, we analyzed by capillary electrophoresis blood samples from 100 females and 102 males from a population of northern Croatia. Statistical analysis included calculation of allele and haplotype frequencies, as well as forensic parameters. The most informative marker for the northern Croatia population was DXS10135 with PIC=0.9211 and a total of 27 alleles. The least polymorphic marker was DXS8378 with 6 alleles. The proportion of observed haplotypes from the number of possible haplotypes varied from 2.74–8.57% across all LGs, with LG1 being the most informative. Of the 11 tested world populations compared to the population of northern Croatia, significant differences in genetic distance (FST) were found for Greenlandic and all non-European populations. We found that all tested markers are in HWE and can thus be used for match probability calculation. Because of high combined power of discrimination in both men and women, Investigator® Argus X-12 is applicable for the northern Croatia population in routine forensic casework. |
format |
Text |
author |
Crnjac, Josip Ozretić, Petar Merkaš, Siniša Ratko, Martina Lozančić, Mateja Korolija, Marina Popović, Maja Mršić, Gordan |
author_facet |
Crnjac, Josip Ozretić, Petar Merkaš, Siniša Ratko, Martina Lozančić, Mateja Korolija, Marina Popović, Maja Mršić, Gordan |
author_sort |
Crnjac, Josip |
title |
Investigator Argus X-12 study on the population of northern Croatia |
title_short |
Investigator Argus X-12 study on the population of northern Croatia |
title_full |
Investigator Argus X-12 study on the population of northern Croatia |
title_fullStr |
Investigator Argus X-12 study on the population of northern Croatia |
title_full_unstemmed |
Investigator Argus X-12 study on the population of northern Croatia |
title_sort |
investigator argus x-12 study on the population of northern croatia |
publisher |
Sociedade Brasileira de Genética |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409765/ http://www.ncbi.nlm.nih.gov/pubmed/27768154 https://doi.org/10.1590/1678-4685-GMB-2015-0261 |
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greenlandic |
genre_facet |
greenlandic |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409765/ http://www.ncbi.nlm.nih.gov/pubmed/27768154 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0261 |
op_rights |
Copyright © 2016, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1590/1678-4685-GMB-2015-0261 |
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Genetics and Molecular Biology |
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40 |
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1 |
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80 |
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83 |
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1766020957490642944 |