An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry
New de novo sources of omega 3 (n-3) long chain polyunsaturated fatty acids (LC-PUFA) are required as alternatives to fish oil in aquafeeds in order to maintain adequate levels of the beneficial fatty acids, eicosapentaenoic and docosahexaenoic (EPA and DHA, respectively). The present study investig...
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ftpubmed:oai:pubmedcentral.nih.gov:5389825 2023-05-15T15:30:50+02:00 An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry Betancor, Mónica B. Li, Keshuai Sprague, Matthew Bardal, Tora Sayanova, Olga Usher, Sarah Han, Lihua Måsøval, Kjell Torrissen, Ole Napier, Johnathan A. Tocher, Douglas R. Olsen, Rolf Erik 2017-04-12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389825/ http://www.ncbi.nlm.nih.gov/pubmed/28403232 https://doi.org/10.1371/journal.pone.0175415 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389825/ http://www.ncbi.nlm.nih.gov/pubmed/28403232 http://dx.doi.org/10.1371/journal.pone.0175415 © 2017 Betancor et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2017 ftpubmed https://doi.org/10.1371/journal.pone.0175415 2017-05-07T00:19:03Z New de novo sources of omega 3 (n-3) long chain polyunsaturated fatty acids (LC-PUFA) are required as alternatives to fish oil in aquafeeds in order to maintain adequate levels of the beneficial fatty acids, eicosapentaenoic and docosahexaenoic (EPA and DHA, respectively). The present study investigated the use of an EPA+DHA oil derived from transgenic Camelina sativa in Atlantic salmon (Salmo salar) feeds containing low levels of fishmeal (35%) and fish oil (10%), reflecting current commercial formulations, to determine the impacts on tissue fatty acid profile, intestinal transcriptome, and health of farmed salmon. Post-smolt Atlantic salmon were fed for 12-weeks with one of three experimental diets containing either a blend of fish oil/rapeseed oil (FO), wild-type camelina oil (WCO) or transgenic camelina oil (DCO) as added lipid source. The DCO diet did not affect any of the fish performance or health parameters studied. Analyses of the mid and hindgut transcriptomes showed only mild effects on metabolism. Flesh of fish fed the DCO diet accumulated almost double the amount of n-3 LC-PUFA than fish fed the FO or WCO diets, indicating that these oils from transgenic oilseeds offer the opportunity to increase the n-3 LC-PUFA in farmed fish to levels comparable to those found a decade ago. Text Atlantic salmon Salmo salar PubMed Central (PMC) PLOS ONE 12 4 e0175415 |
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Research Article Betancor, Mónica B. Li, Keshuai Sprague, Matthew Bardal, Tora Sayanova, Olga Usher, Sarah Han, Lihua Måsøval, Kjell Torrissen, Ole Napier, Johnathan A. Tocher, Douglas R. Olsen, Rolf Erik An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry |
topic_facet |
Research Article |
description |
New de novo sources of omega 3 (n-3) long chain polyunsaturated fatty acids (LC-PUFA) are required as alternatives to fish oil in aquafeeds in order to maintain adequate levels of the beneficial fatty acids, eicosapentaenoic and docosahexaenoic (EPA and DHA, respectively). The present study investigated the use of an EPA+DHA oil derived from transgenic Camelina sativa in Atlantic salmon (Salmo salar) feeds containing low levels of fishmeal (35%) and fish oil (10%), reflecting current commercial formulations, to determine the impacts on tissue fatty acid profile, intestinal transcriptome, and health of farmed salmon. Post-smolt Atlantic salmon were fed for 12-weeks with one of three experimental diets containing either a blend of fish oil/rapeseed oil (FO), wild-type camelina oil (WCO) or transgenic camelina oil (DCO) as added lipid source. The DCO diet did not affect any of the fish performance or health parameters studied. Analyses of the mid and hindgut transcriptomes showed only mild effects on metabolism. Flesh of fish fed the DCO diet accumulated almost double the amount of n-3 LC-PUFA than fish fed the FO or WCO diets, indicating that these oils from transgenic oilseeds offer the opportunity to increase the n-3 LC-PUFA in farmed fish to levels comparable to those found a decade ago. |
format |
Text |
author |
Betancor, Mónica B. Li, Keshuai Sprague, Matthew Bardal, Tora Sayanova, Olga Usher, Sarah Han, Lihua Måsøval, Kjell Torrissen, Ole Napier, Johnathan A. Tocher, Douglas R. Olsen, Rolf Erik |
author_facet |
Betancor, Mónica B. Li, Keshuai Sprague, Matthew Bardal, Tora Sayanova, Olga Usher, Sarah Han, Lihua Måsøval, Kjell Torrissen, Ole Napier, Johnathan A. Tocher, Douglas R. Olsen, Rolf Erik |
author_sort |
Betancor, Mónica B. |
title |
An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry |
title_short |
An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry |
title_full |
An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry |
title_fullStr |
An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry |
title_full_unstemmed |
An oil containing EPA and DHA from transgenic Camelina sativa to replace marine fish oil in feeds for Atlantic salmon (Salmo salar L.): Effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry |
title_sort |
oil containing epa and dha from transgenic camelina sativa to replace marine fish oil in feeds for atlantic salmon (salmo salar l.): effects on intestinal transcriptome, histology, tissue fatty acid profiles and plasma biochemistry |
publisher |
Public Library of Science |
publishDate |
2017 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389825/ http://www.ncbi.nlm.nih.gov/pubmed/28403232 https://doi.org/10.1371/journal.pone.0175415 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389825/ http://www.ncbi.nlm.nih.gov/pubmed/28403232 http://dx.doi.org/10.1371/journal.pone.0175415 |
op_rights |
© 2017 Betancor et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0175415 |
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PLOS ONE |
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12 |
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