Pulmonary neuroendocrine tumor in a female wolf (Canis lupus lupus)

• Published in: Journal of Veterinary Medical Science
• Main Authors: SHIRAKI, Ayako, YOSHIDA, Toshinori, KAWASHIMA, Masahi, MURAYAMA, Hirotada, NAGAHARA, Rei, ITO, Nanao, SHIBUTANI, Makoto
• Format: Text
• Language: English
• Published: The Japanese Society of Veterinary Science 2017
• Subjects: Pathology; Canis lupus
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383182/; http://www.ncbi.nlm.nih.gov/pubmed/28190820; https://doi.org/10.1292/jvms.16-0490

A 17-year-old female wolf (Canis lupus lupus) had a right lung mass that was adhered to the thoracic cavity. Histopathological examination revealed that the mass consisted of sheets, cord or ribbon-like structures of monotonous, small, cuboidal cells with round, oval or short-spindle nuclei and scant clear cytoplasm, demarcated by a fine fibrovascular stroma. Focal necrosis, congestion and thrombi were observed. Immunohistochemically, the tumor cells diffusely expressed cytokeratin AE1/AE3, and some expressed chromogranin A, neural cell adhesion molecule (CD56) and thyroid transcription factor-1. The number of proliferating cell nuclear antigen-positive tumor cells was low. A diagnosis of pulmonary neuroendocrine tumor was based on the resemblance to carcinoids.