Insights from the Den: How Hibernating Bears May Help Us Understand and Treat Human Disease
Hibernating brown bears (Ursus arctos) and black bears (Ursus americanus) spend half of the year in a physically inactive state inside their winter dens without food intake and defecating and no or little urination. Under similar extreme conditions, humans would suffer from loss of lean body mass, h...
Published in: | Clinical and Translational Science |
---|---|
Main Authors: | , , |
Format: | Text |
Language: | English |
Published: |
John Wiley and Sons Inc.
2015
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351099/ http://www.ncbi.nlm.nih.gov/pubmed/26083277 https://doi.org/10.1111/cts.12279 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:5351099 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:5351099 2023-05-15T18:42:04+02:00 Insights from the Den: How Hibernating Bears May Help Us Understand and Treat Human Disease Berg von Linde, Maria Arevström, Lilith Fröbert, Ole 2015-06-17 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351099/ http://www.ncbi.nlm.nih.gov/pubmed/26083277 https://doi.org/10.1111/cts.12279 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351099/ http://www.ncbi.nlm.nih.gov/pubmed/26083277 http://dx.doi.org/10.1111/cts.12279 © 2015 Wiley Periodicals, Inc. Original Research Articles Text 2015 ftpubmed https://doi.org/10.1111/cts.12279 2017-05-28T00:03:58Z Hibernating brown bears (Ursus arctos) and black bears (Ursus americanus) spend half of the year in a physically inactive state inside their winter dens without food intake and defecating and no or little urination. Under similar extreme conditions, humans would suffer from loss of lean body mass, heart failure, thrombosis, azotemia, osteoporosis, and more. However, bears exit the den in the spring strong without organ injuries. Translational animal models are used in human medicine but traditional experimental animals have several shortcomings; thus, we believe that it is time to systematically explore new models. In this review paper, we describe physiological adaptations of hibernating bears and how similar adaptations in humans could theoretically alleviate medical conditions. The bear has solved most of the health challenges faced by humans, including heart and kidney disease, atherosclerosis and thrombosis, and muscle wasting and osteoporosis. Understanding and applying this library of information could lead to a number of major discoveries that could have implications for the understanding and treatment of human disease. Text Ursus arctos PubMed Central (PMC) Clinical and Translational Science 8 5 601 605 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Original Research Articles |
spellingShingle |
Original Research Articles Berg von Linde, Maria Arevström, Lilith Fröbert, Ole Insights from the Den: How Hibernating Bears May Help Us Understand and Treat Human Disease |
topic_facet |
Original Research Articles |
description |
Hibernating brown bears (Ursus arctos) and black bears (Ursus americanus) spend half of the year in a physically inactive state inside their winter dens without food intake and defecating and no or little urination. Under similar extreme conditions, humans would suffer from loss of lean body mass, heart failure, thrombosis, azotemia, osteoporosis, and more. However, bears exit the den in the spring strong without organ injuries. Translational animal models are used in human medicine but traditional experimental animals have several shortcomings; thus, we believe that it is time to systematically explore new models. In this review paper, we describe physiological adaptations of hibernating bears and how similar adaptations in humans could theoretically alleviate medical conditions. The bear has solved most of the health challenges faced by humans, including heart and kidney disease, atherosclerosis and thrombosis, and muscle wasting and osteoporosis. Understanding and applying this library of information could lead to a number of major discoveries that could have implications for the understanding and treatment of human disease. |
format |
Text |
author |
Berg von Linde, Maria Arevström, Lilith Fröbert, Ole |
author_facet |
Berg von Linde, Maria Arevström, Lilith Fröbert, Ole |
author_sort |
Berg von Linde, Maria |
title |
Insights from the Den: How Hibernating Bears May Help Us Understand and Treat Human Disease |
title_short |
Insights from the Den: How Hibernating Bears May Help Us Understand and Treat Human Disease |
title_full |
Insights from the Den: How Hibernating Bears May Help Us Understand and Treat Human Disease |
title_fullStr |
Insights from the Den: How Hibernating Bears May Help Us Understand and Treat Human Disease |
title_full_unstemmed |
Insights from the Den: How Hibernating Bears May Help Us Understand and Treat Human Disease |
title_sort |
insights from the den: how hibernating bears may help us understand and treat human disease |
publisher |
John Wiley and Sons Inc. |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351099/ http://www.ncbi.nlm.nih.gov/pubmed/26083277 https://doi.org/10.1111/cts.12279 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351099/ http://www.ncbi.nlm.nih.gov/pubmed/26083277 http://dx.doi.org/10.1111/cts.12279 |
op_rights |
© 2015 Wiley Periodicals, Inc. |
op_doi |
https://doi.org/10.1111/cts.12279 |
container_title |
Clinical and Translational Science |
container_volume |
8 |
container_issue |
5 |
container_start_page |
601 |
op_container_end_page |
605 |
_version_ |
1766231676264906752 |