Genetic signature of natural selection in first Americans

There is much interest in understanding the role of natural selection in shaping physiological adaptations to climate, diet, and diseases in humans. We investigated this issue by analyzing genomic data from Native American populations inhabiting different ecological regions and ancient Native Americ...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences
Main Authors: G. Amorim, Carlos Eduardo, Nunes, Kelly, Meyer, Diogo, Comas, David, Bortolini, Maria Cátira, Salzano, Francisco Mauro, Hünemeier, Tábita
Format: Text
Language:English
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Arctic
Greenland
Arctic Population
Beringia
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338486/
http://www.ncbi.nlm.nih.gov/pubmed/28193867
https://doi.org/10.1073/pnas.1620541114
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Summary:There is much interest in understanding the role of natural selection in shaping physiological adaptations to climate, diet, and diseases in humans. We investigated this issue by analyzing genomic data from Native American populations inhabiting different ecological regions and ancient Native Americans. We found signals of natural selection at the fatty acid desaturases (FADS) genes not only in an Arctic population, as was previously found, but throughout the Americas, suggesting a single and strong adaptive event that occurred in Beringia, before the range expansion of the first Americans within the American continent and Greenland.

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