Physical and neuro-behavioural determinants of reproductive onset and success
The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behaviour and success, respectively. These sequenced events have behavioural, physiological and health significance, and may also influence overall reproductive fitness. In a genome-wide associat...
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ftpubmed:oai:pubmedcentral.nih.gov:5238953 2023-05-15T16:50:58+02:00 Physical and neuro-behavioural determinants of reproductive onset and success Day, Felix R. Helgason, Hannes Chasman, Daniel I. Rose, Lynda M. Loh, Po-Ru Scott, Robert A. Helgason, Agnar Kong, Augustine Masson, Gisli Magnusson, Olafur Th. Gudbjartsson, Daniel Thorsteinsdottir, Unnur Buring, Julie E. Ridker, Paul M. Sulem, Patrick Stefansson, Kari Ong, Ken K. Perry, John R.B. 2016-04-18 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238953/ http://www.ncbi.nlm.nih.gov/pubmed/27089180 https://doi.org/10.1038/ng.3551 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238953/ http://www.ncbi.nlm.nih.gov/pubmed/27089180 http://dx.doi.org/10.1038/ng.3551 Article Text 2016 ftpubmed https://doi.org/10.1038/ng.3551 2017-01-22T01:14:21Z The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behaviour and success, respectively. These sequenced events have behavioural, physiological and health significance, and may also influence overall reproductive fitness. In a genome-wide association study of 125,667 white men and women aged 40-69 in the UK Biobank Study, we identify 38 sequence variants with association P-values <5×10-8 with age at first sexual intercourse. Findings were taken forward in up to 241,910 men and women from deCODE Iceland and 20,187 from Women’s Genome Health Study. Several of these loci also exhibit strong associations with behavioural traits (rs4856591 in CADM2 and risk taking propensity: P=4.3×10-10; rs73195303 in MSRA and irritable temperament: P=5.8×10-11) and other reproductive traits (rs67229052 in ESR1 and both age at first birth: P=1.2x10-13 and number of children: P=4.8×10-12; rs2188151 in SEMA3F and age at first birth: P=8.76×10-15). In Mendelian randomisation analyses, we demonstrate likely causal influences of earlier puberty timing on earlier first sexual intercourse, earlier first birth and fewer years of education. In turn, likely causal consequences of earlier first sexual intercourse include reproductive, educational, psychiatric and cardiometabolic outcomes. These findings point to the existence of developmental and neuro-behavioural regulators of reproductive activity and success. Text Iceland PubMed Central (PMC) Nature Genetics 48 6 617 623 |
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Article Day, Felix R. Helgason, Hannes Chasman, Daniel I. Rose, Lynda M. Loh, Po-Ru Scott, Robert A. Helgason, Agnar Kong, Augustine Masson, Gisli Magnusson, Olafur Th. Gudbjartsson, Daniel Thorsteinsdottir, Unnur Buring, Julie E. Ridker, Paul M. Sulem, Patrick Stefansson, Kari Ong, Ken K. Perry, John R.B. Physical and neuro-behavioural determinants of reproductive onset and success |
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description |
The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behaviour and success, respectively. These sequenced events have behavioural, physiological and health significance, and may also influence overall reproductive fitness. In a genome-wide association study of 125,667 white men and women aged 40-69 in the UK Biobank Study, we identify 38 sequence variants with association P-values <5×10-8 with age at first sexual intercourse. Findings were taken forward in up to 241,910 men and women from deCODE Iceland and 20,187 from Women’s Genome Health Study. Several of these loci also exhibit strong associations with behavioural traits (rs4856591 in CADM2 and risk taking propensity: P=4.3×10-10; rs73195303 in MSRA and irritable temperament: P=5.8×10-11) and other reproductive traits (rs67229052 in ESR1 and both age at first birth: P=1.2x10-13 and number of children: P=4.8×10-12; rs2188151 in SEMA3F and age at first birth: P=8.76×10-15). In Mendelian randomisation analyses, we demonstrate likely causal influences of earlier puberty timing on earlier first sexual intercourse, earlier first birth and fewer years of education. In turn, likely causal consequences of earlier first sexual intercourse include reproductive, educational, psychiatric and cardiometabolic outcomes. These findings point to the existence of developmental and neuro-behavioural regulators of reproductive activity and success. |
format |
Text |
author |
Day, Felix R. Helgason, Hannes Chasman, Daniel I. Rose, Lynda M. Loh, Po-Ru Scott, Robert A. Helgason, Agnar Kong, Augustine Masson, Gisli Magnusson, Olafur Th. Gudbjartsson, Daniel Thorsteinsdottir, Unnur Buring, Julie E. Ridker, Paul M. Sulem, Patrick Stefansson, Kari Ong, Ken K. Perry, John R.B. |
author_facet |
Day, Felix R. Helgason, Hannes Chasman, Daniel I. Rose, Lynda M. Loh, Po-Ru Scott, Robert A. Helgason, Agnar Kong, Augustine Masson, Gisli Magnusson, Olafur Th. Gudbjartsson, Daniel Thorsteinsdottir, Unnur Buring, Julie E. Ridker, Paul M. Sulem, Patrick Stefansson, Kari Ong, Ken K. Perry, John R.B. |
author_sort |
Day, Felix R. |
title |
Physical and neuro-behavioural determinants of reproductive onset and success |
title_short |
Physical and neuro-behavioural determinants of reproductive onset and success |
title_full |
Physical and neuro-behavioural determinants of reproductive onset and success |
title_fullStr |
Physical and neuro-behavioural determinants of reproductive onset and success |
title_full_unstemmed |
Physical and neuro-behavioural determinants of reproductive onset and success |
title_sort |
physical and neuro-behavioural determinants of reproductive onset and success |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238953/ http://www.ncbi.nlm.nih.gov/pubmed/27089180 https://doi.org/10.1038/ng.3551 |
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Iceland |
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Iceland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238953/ http://www.ncbi.nlm.nih.gov/pubmed/27089180 http://dx.doi.org/10.1038/ng.3551 |
op_doi |
https://doi.org/10.1038/ng.3551 |
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Nature Genetics |
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48 |
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6 |
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617 |
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623 |
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1766041080371871744 |