Biocatalytic synthesis of allylic and allenyl sulfides via a myoglobin-catalyzed Doyle-Kirmse reaction
The first example of a biocatalytic [2,3]-sigmatropic rearrangement reaction involving allylic sulfides and diazo reagents (Doyle-Kirmse reaction) is reported. Engineered variants of sperm whale myoglobin catalyze this synthetically valuable C–C bond forming transformation with high efficiency and p...
Published in: | Angewandte Chemie International Edition |
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Main Authors: | , , , , |
Format: | Text |
Language: | English |
Published: |
2016
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Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189672/ http://www.ncbi.nlm.nih.gov/pubmed/27647732 https://doi.org/10.1002/anie.201607278 |