Organometallic myoglobins: Formation of Fe–carbon bonds and distal pocket effects on aryl ligand conformations
Bioorganometallic Fe–C bonds are biologically relevant species that may result from the metabolism of natural or synthetic hydrazines. The molecular structures of four new sperm whale mutant myoglobin derivatives with Fe–aryl moieties, namely H64A–tolyl-m, H64A–chlorophenyl-p, H64Q–tolyl-m, and H64Q...
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ftpubmed:oai:pubmedcentral.nih.gov:5159213 2023-05-15T18:26:41+02:00 Organometallic myoglobins: Formation of Fe–carbon bonds and distal pocket effects on aryl ligand conformations Wang, Bing Thomas, Leonard M. Richter-Addo, George B. 2016-06-24 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159213/ http://www.ncbi.nlm.nih.gov/pubmed/27687333 https://doi.org/10.1016/j.jinorgbio.2016.06.028 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159213/ http://www.ncbi.nlm.nih.gov/pubmed/27687333 http://dx.doi.org/10.1016/j.jinorgbio.2016.06.028 Article Text 2016 ftpubmed https://doi.org/10.1016/j.jinorgbio.2016.06.028 2017-11-05T01:13:01Z Bioorganometallic Fe–C bonds are biologically relevant species that may result from the metabolism of natural or synthetic hydrazines. The molecular structures of four new sperm whale mutant myoglobin derivatives with Fe–aryl moieties, namely H64A–tolyl-m, H64A–chlorophenyl-p, H64Q–tolyl-m, and H64Q–chlorophenyl-p, have been determined at 1.7-1.9 Å resolution. The structures reveal conformational preferences for the substituted aryls resulting from attachment of the aryl ligands to Fe at the site of net −NHNH2 release from the precursor hydrazines, and show distal pocket changes that readily accommodate these bulky ligands. Text Sperm whale PubMed Central (PMC) Journal of Inorganic Biochemistry 164 1 4 |
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Article Wang, Bing Thomas, Leonard M. Richter-Addo, George B. Organometallic myoglobins: Formation of Fe–carbon bonds and distal pocket effects on aryl ligand conformations |
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Article |
description |
Bioorganometallic Fe–C bonds are biologically relevant species that may result from the metabolism of natural or synthetic hydrazines. The molecular structures of four new sperm whale mutant myoglobin derivatives with Fe–aryl moieties, namely H64A–tolyl-m, H64A–chlorophenyl-p, H64Q–tolyl-m, and H64Q–chlorophenyl-p, have been determined at 1.7-1.9 Å resolution. The structures reveal conformational preferences for the substituted aryls resulting from attachment of the aryl ligands to Fe at the site of net −NHNH2 release from the precursor hydrazines, and show distal pocket changes that readily accommodate these bulky ligands. |
format |
Text |
author |
Wang, Bing Thomas, Leonard M. Richter-Addo, George B. |
author_facet |
Wang, Bing Thomas, Leonard M. Richter-Addo, George B. |
author_sort |
Wang, Bing |
title |
Organometallic myoglobins: Formation of Fe–carbon bonds and distal pocket effects on aryl ligand conformations |
title_short |
Organometallic myoglobins: Formation of Fe–carbon bonds and distal pocket effects on aryl ligand conformations |
title_full |
Organometallic myoglobins: Formation of Fe–carbon bonds and distal pocket effects on aryl ligand conformations |
title_fullStr |
Organometallic myoglobins: Formation of Fe–carbon bonds and distal pocket effects on aryl ligand conformations |
title_full_unstemmed |
Organometallic myoglobins: Formation of Fe–carbon bonds and distal pocket effects on aryl ligand conformations |
title_sort |
organometallic myoglobins: formation of fe–carbon bonds and distal pocket effects on aryl ligand conformations |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159213/ http://www.ncbi.nlm.nih.gov/pubmed/27687333 https://doi.org/10.1016/j.jinorgbio.2016.06.028 |
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Sperm whale |
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Sperm whale |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159213/ http://www.ncbi.nlm.nih.gov/pubmed/27687333 http://dx.doi.org/10.1016/j.jinorgbio.2016.06.028 |
op_doi |
https://doi.org/10.1016/j.jinorgbio.2016.06.028 |
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Journal of Inorganic Biochemistry |
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164 |
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1 |
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4 |
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1766208653560381440 |