Rapid Karyotype Evolution in Lasiopodomys Involved at Least Two Autosome – Sex Chromosome Translocations
The generic status of Lasiopodomys and its division into subgenera Lasiopodomys (L. mandarinus, L. brandtii) and Stenocranius (L. gregalis, L. raddei) are not generally accepted because of contradictions between the morphological and molecular data. To obtain cytogenetic evidence for the Lasiopodomy...
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ftpubmed:oai:pubmedcentral.nih.gov:5147937 2023-05-15T14:31:37+02:00 Rapid Karyotype Evolution in Lasiopodomys Involved at Least Two Autosome – Sex Chromosome Translocations Gladkikh, Olga L. Romanenko, Svetlana A. Lemskaya, Natalya A. Serdyukova, Natalya A. O’Brien, Patricia C. M. Kovalskaya, Julia M. Smorkatcheva, Antonina V. Golenishchev, Feodor N. Perelman, Polina L. Trifonov, Vladimir A. Ferguson-Smith, Malcolm A. Yang, Fengtang Graphodatsky, Alexander S. 2016-12-09 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147937/ http://www.ncbi.nlm.nih.gov/pubmed/27936177 https://doi.org/10.1371/journal.pone.0167653 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147937/ http://www.ncbi.nlm.nih.gov/pubmed/27936177 http://dx.doi.org/10.1371/journal.pone.0167653 © 2016 Gladkikh et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2016 ftpubmed https://doi.org/10.1371/journal.pone.0167653 2017-01-01T01:00:40Z The generic status of Lasiopodomys and its division into subgenera Lasiopodomys (L. mandarinus, L. brandtii) and Stenocranius (L. gregalis, L. raddei) are not generally accepted because of contradictions between the morphological and molecular data. To obtain cytogenetic evidence for the Lasiopodomys genus and its subgenera and to test the autosome to sex chromosome translocation hypothesis of sex chromosome complex origin in L. mandarinus proposed previously, we hybridized chromosome painting probes from the field vole (Microtus agrestis, MAG) and the Arctic lemming (Dicrostonyx torquatus, DTO) onto the metaphases of a female Mandarin vole (L. mandarinus, 2n = 47) and a male Brandt's vole (L. brandtii, 2n = 34). In addition, we hybridized Arctic lemming painting probes onto chromosomes of a female narrow-headed vole (L. gregalis, 2n = 36). Cross-species painting revealed three cytogenetic signatures (MAG12/18, 17a/19, and 22/24) that could validate the genus Lasiopodomys and indicate the evolutionary affinity of L. gregalis to the genus. Moreover, all three species retained the associations MAG1bc/17b and 2/8a detected previously in karyotypes of all arvicolins studied. The associations MAG2a/8a/19b, 8b/21, 9b/23, 11/13b, 12b/18, 17a/19a, and 5 fissions of ancestral segments appear to be characteristic for the subgenus Lasiopodomys. We also validated the autosome to sex chromosome translocation hypothesis on the origin of complex sex chromosomes in L. mandarinus. Two translocations of autosomes onto the ancestral X chromosome in L. mandarinus led to a complex of neo-X1, neo-X2, and neo-X3 elements. Our results demonstrate that genus Lasiopodomys represents a striking example of rapid chromosome evolution involving both autosomes and sex chromosomes. Multiple reshuffling events including Robertsonian fusions, chromosomal fissions, inversions and heterochromatin expansion have led to the formation of modern species karyotypes in a very short time, about 2.4 MY. Text Arctic Lemming Arctic Dicrostonyx torquatus PubMed Central (PMC) Arctic PLOS ONE 11 12 e0167653 |
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Research Article |
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Research Article Gladkikh, Olga L. Romanenko, Svetlana A. Lemskaya, Natalya A. Serdyukova, Natalya A. O’Brien, Patricia C. M. Kovalskaya, Julia M. Smorkatcheva, Antonina V. Golenishchev, Feodor N. Perelman, Polina L. Trifonov, Vladimir A. Ferguson-Smith, Malcolm A. Yang, Fengtang Graphodatsky, Alexander S. Rapid Karyotype Evolution in Lasiopodomys Involved at Least Two Autosome – Sex Chromosome Translocations |
topic_facet |
Research Article |
description |
The generic status of Lasiopodomys and its division into subgenera Lasiopodomys (L. mandarinus, L. brandtii) and Stenocranius (L. gregalis, L. raddei) are not generally accepted because of contradictions between the morphological and molecular data. To obtain cytogenetic evidence for the Lasiopodomys genus and its subgenera and to test the autosome to sex chromosome translocation hypothesis of sex chromosome complex origin in L. mandarinus proposed previously, we hybridized chromosome painting probes from the field vole (Microtus agrestis, MAG) and the Arctic lemming (Dicrostonyx torquatus, DTO) onto the metaphases of a female Mandarin vole (L. mandarinus, 2n = 47) and a male Brandt's vole (L. brandtii, 2n = 34). In addition, we hybridized Arctic lemming painting probes onto chromosomes of a female narrow-headed vole (L. gregalis, 2n = 36). Cross-species painting revealed three cytogenetic signatures (MAG12/18, 17a/19, and 22/24) that could validate the genus Lasiopodomys and indicate the evolutionary affinity of L. gregalis to the genus. Moreover, all three species retained the associations MAG1bc/17b and 2/8a detected previously in karyotypes of all arvicolins studied. The associations MAG2a/8a/19b, 8b/21, 9b/23, 11/13b, 12b/18, 17a/19a, and 5 fissions of ancestral segments appear to be characteristic for the subgenus Lasiopodomys. We also validated the autosome to sex chromosome translocation hypothesis on the origin of complex sex chromosomes in L. mandarinus. Two translocations of autosomes onto the ancestral X chromosome in L. mandarinus led to a complex of neo-X1, neo-X2, and neo-X3 elements. Our results demonstrate that genus Lasiopodomys represents a striking example of rapid chromosome evolution involving both autosomes and sex chromosomes. Multiple reshuffling events including Robertsonian fusions, chromosomal fissions, inversions and heterochromatin expansion have led to the formation of modern species karyotypes in a very short time, about 2.4 MY. |
format |
Text |
author |
Gladkikh, Olga L. Romanenko, Svetlana A. Lemskaya, Natalya A. Serdyukova, Natalya A. O’Brien, Patricia C. M. Kovalskaya, Julia M. Smorkatcheva, Antonina V. Golenishchev, Feodor N. Perelman, Polina L. Trifonov, Vladimir A. Ferguson-Smith, Malcolm A. Yang, Fengtang Graphodatsky, Alexander S. |
author_facet |
Gladkikh, Olga L. Romanenko, Svetlana A. Lemskaya, Natalya A. Serdyukova, Natalya A. O’Brien, Patricia C. M. Kovalskaya, Julia M. Smorkatcheva, Antonina V. Golenishchev, Feodor N. Perelman, Polina L. Trifonov, Vladimir A. Ferguson-Smith, Malcolm A. Yang, Fengtang Graphodatsky, Alexander S. |
author_sort |
Gladkikh, Olga L. |
title |
Rapid Karyotype Evolution in Lasiopodomys Involved at Least Two Autosome – Sex Chromosome Translocations |
title_short |
Rapid Karyotype Evolution in Lasiopodomys Involved at Least Two Autosome – Sex Chromosome Translocations |
title_full |
Rapid Karyotype Evolution in Lasiopodomys Involved at Least Two Autosome – Sex Chromosome Translocations |
title_fullStr |
Rapid Karyotype Evolution in Lasiopodomys Involved at Least Two Autosome – Sex Chromosome Translocations |
title_full_unstemmed |
Rapid Karyotype Evolution in Lasiopodomys Involved at Least Two Autosome – Sex Chromosome Translocations |
title_sort |
rapid karyotype evolution in lasiopodomys involved at least two autosome – sex chromosome translocations |
publisher |
Public Library of Science |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147937/ http://www.ncbi.nlm.nih.gov/pubmed/27936177 https://doi.org/10.1371/journal.pone.0167653 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Lemming Arctic Dicrostonyx torquatus |
genre_facet |
Arctic Lemming Arctic Dicrostonyx torquatus |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147937/ http://www.ncbi.nlm.nih.gov/pubmed/27936177 http://dx.doi.org/10.1371/journal.pone.0167653 |
op_rights |
© 2016 Gladkikh et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0167653 |
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PLOS ONE |
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11 |
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12 |
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e0167653 |
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