How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime
European eels (Anguilla anguilla) undertake an impressive 5 000 km long migration from European fresh waters through the North Atlantic Ocean to the Sargasso Sea. Along with sexual maturation, the eel skeleton undergoes a remarkable morphological transformation during migration, where a hitherto com...
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ftpubmed:oai:pubmedcentral.nih.gov:5095380 2023-05-15T13:27:06+02:00 How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime Rolvien, Tim Nagel, Florian Milovanovic, Petar Wuertz, Sven Marshall, Robert Percy Jeschke, Anke Schmidt, Felix N. Hahn, Michael Witten, P. Eckhard Amling, Michael Busse, Björn 2016-10-26 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095380/ http://www.ncbi.nlm.nih.gov/pubmed/27798301 https://doi.org/10.1098/rspb.2016.1550 en eng The Royal Society http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095380/ http://www.ncbi.nlm.nih.gov/pubmed/27798301 http://dx.doi.org/10.1098/rspb.2016.1550 © 2016 The Author(s) http://royalsocietypublishing.org/licence Published by the Royal Society. All rights reserved. Research Articles Text 2016 ftpubmed https://doi.org/10.1098/rspb.2016.1550 2017-10-29T00:01:59Z European eels (Anguilla anguilla) undertake an impressive 5 000 km long migration from European fresh waters through the North Atlantic Ocean to the Sargasso Sea. Along with sexual maturation, the eel skeleton undergoes a remarkable morphological transformation during migration, where a hitherto completely obscure bone loss phenomenon occurs. To unravel mechanisms of the maturation-related decay of the skeleton, we performed a multiscale assessment of eels' bones at different life-cycle stages. Accordingly, the skeleton reflects extensive bone loss that is mediated via multinucleated bone-resorbing osteoclasts, while other resorption mechanisms such as osteocytic osteolysis or matrix demineralization were not observed. Preserving mechanical stability and releasing minerals for energy metabolism are two mutually exclusive functions of the skeleton that are orchestrated in eels through the presence of two spatially segregated hard tissues: cellular bone and acellular notochord. The cellular bone serves as a source of mineral release following osteoclastic resorption, whereas the mineralized notochord sheath, which is inaccessible for resorption processes due to an unmineralized cover layer, ensures sufficient mechanical stability as a part of the notochord sheath. Clearly, an eel's skeleton is structurally optimized to meet the metabolic challenge of fasting and simultaneous sexual development during an exhausting journey to spawning areas, while the function of the vertebral column is maintained to achieve this goal. Text Anguilla anguilla North Atlantic PubMed Central (PMC) Proceedings of the Royal Society B: Biological Sciences 283 1841 20161550 |
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Research Articles Rolvien, Tim Nagel, Florian Milovanovic, Petar Wuertz, Sven Marshall, Robert Percy Jeschke, Anke Schmidt, Felix N. Hahn, Michael Witten, P. Eckhard Amling, Michael Busse, Björn How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime |
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Research Articles |
description |
European eels (Anguilla anguilla) undertake an impressive 5 000 km long migration from European fresh waters through the North Atlantic Ocean to the Sargasso Sea. Along with sexual maturation, the eel skeleton undergoes a remarkable morphological transformation during migration, where a hitherto completely obscure bone loss phenomenon occurs. To unravel mechanisms of the maturation-related decay of the skeleton, we performed a multiscale assessment of eels' bones at different life-cycle stages. Accordingly, the skeleton reflects extensive bone loss that is mediated via multinucleated bone-resorbing osteoclasts, while other resorption mechanisms such as osteocytic osteolysis or matrix demineralization were not observed. Preserving mechanical stability and releasing minerals for energy metabolism are two mutually exclusive functions of the skeleton that are orchestrated in eels through the presence of two spatially segregated hard tissues: cellular bone and acellular notochord. The cellular bone serves as a source of mineral release following osteoclastic resorption, whereas the mineralized notochord sheath, which is inaccessible for resorption processes due to an unmineralized cover layer, ensures sufficient mechanical stability as a part of the notochord sheath. Clearly, an eel's skeleton is structurally optimized to meet the metabolic challenge of fasting and simultaneous sexual development during an exhausting journey to spawning areas, while the function of the vertebral column is maintained to achieve this goal. |
format |
Text |
author |
Rolvien, Tim Nagel, Florian Milovanovic, Petar Wuertz, Sven Marshall, Robert Percy Jeschke, Anke Schmidt, Felix N. Hahn, Michael Witten, P. Eckhard Amling, Michael Busse, Björn |
author_facet |
Rolvien, Tim Nagel, Florian Milovanovic, Petar Wuertz, Sven Marshall, Robert Percy Jeschke, Anke Schmidt, Felix N. Hahn, Michael Witten, P. Eckhard Amling, Michael Busse, Björn |
author_sort |
Rolvien, Tim |
title |
How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime |
title_short |
How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime |
title_full |
How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime |
title_fullStr |
How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime |
title_full_unstemmed |
How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime |
title_sort |
how the european eel (anguilla anguilla) loses its skeletal framework across lifetime |
publisher |
The Royal Society |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095380/ http://www.ncbi.nlm.nih.gov/pubmed/27798301 https://doi.org/10.1098/rspb.2016.1550 |
genre |
Anguilla anguilla North Atlantic |
genre_facet |
Anguilla anguilla North Atlantic |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095380/ http://www.ncbi.nlm.nih.gov/pubmed/27798301 http://dx.doi.org/10.1098/rspb.2016.1550 |
op_rights |
© 2016 The Author(s) http://royalsocietypublishing.org/licence Published by the Royal Society. All rights reserved. |
op_doi |
https://doi.org/10.1098/rspb.2016.1550 |
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Proceedings of the Royal Society B: Biological Sciences |
container_volume |
283 |
container_issue |
1841 |
container_start_page |
20161550 |
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1766396416949747712 |