Distribution of DI*A and DI*B Allele Frequencies and Comparisons among Central Thai and Other Populations
Alloantibodies to the Diego (DI) blood group system, anti-Dia and anti-Dib are clinically significant in causing hemolytic transfusion reactions (HTRs) and hemolytic disease of the fetus and newborn (HDFN), especially in Asian populations with Mongolian ancestry. This study aimed to report the frequ...
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ftpubmed:oai:pubmedcentral.nih.gov:5072727 2023-05-15T13:14:32+02:00 Distribution of DI*A and DI*B Allele Frequencies and Comparisons among Central Thai and Other Populations Nathalang, Oytip Panichrum, Puangpaka Intharanut, Kamphon Thattanon, Phatchira Nathalang, Siriporn 2016-10-20 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072727/ http://www.ncbi.nlm.nih.gov/pubmed/27764238 https://doi.org/10.1371/journal.pone.0165134 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072727/ http://www.ncbi.nlm.nih.gov/pubmed/27764238 http://dx.doi.org/10.1371/journal.pone.0165134 © 2016 Nathalang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2016 ftpubmed https://doi.org/10.1371/journal.pone.0165134 2016-10-30T00:15:32Z Alloantibodies to the Diego (DI) blood group system, anti-Dia and anti-Dib are clinically significant in causing hemolytic transfusion reactions (HTRs) and hemolytic disease of the fetus and newborn (HDFN), especially in Asian populations with Mongolian ancestry. This study aimed to report the frequency of the DI*A and DI*B alleles in a Central Thai population and to compare them with those of other populations previously published. Altogether, 1,011 blood samples from unrelated healthy blood donors at the National Blood Centre, Thai Red Cross Society, Bangkok were included. Only 391 samples were tested with anti-Dia by conventional tube technique. All samples were genotyped for DI*A and DI*B alleles using an in-house polymerase chain reaction with sequence-specific primer (PCR-SSP) technique. The DI phenotyping and genotyping results were in 100% concordance. The DI*A and DI*B allele frequencies among 1,011 Central Thais were 0.0183 (37/2,022) and 0.9817 (1,985/2,022), respectively. Allele frequencies were compared between Central Thai and other populations. Our data shows that DI*A and DI*B allele frequencies are similar to Southeast Asian, Brazilian, Southern Brazilian and American Native populations; whereas, these frequencies significantly differ from those reported in East Asian, Italian, Alaska Native/Aleut, Hawaiian/Pacific Islander and Filipino populations (P<0.05), corresponding to the results of a matrix of geometric genetic distances. This study confirms that the prevalence of DI*A and DI*B alleles among Central Thais is similar to Southeast Asians and different to others populations of the world. A PCR-based identification of DI genotyping should overcome some of the serological limitations in transfusion medicine and provides a complementary tool for further population-genetic studies. Text aleut Alaska PubMed Central (PMC) Pacific PLOS ONE 11 10 e0165134 |
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Research Article Nathalang, Oytip Panichrum, Puangpaka Intharanut, Kamphon Thattanon, Phatchira Nathalang, Siriporn Distribution of DI*A and DI*B Allele Frequencies and Comparisons among Central Thai and Other Populations |
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description |
Alloantibodies to the Diego (DI) blood group system, anti-Dia and anti-Dib are clinically significant in causing hemolytic transfusion reactions (HTRs) and hemolytic disease of the fetus and newborn (HDFN), especially in Asian populations with Mongolian ancestry. This study aimed to report the frequency of the DI*A and DI*B alleles in a Central Thai population and to compare them with those of other populations previously published. Altogether, 1,011 blood samples from unrelated healthy blood donors at the National Blood Centre, Thai Red Cross Society, Bangkok were included. Only 391 samples were tested with anti-Dia by conventional tube technique. All samples were genotyped for DI*A and DI*B alleles using an in-house polymerase chain reaction with sequence-specific primer (PCR-SSP) technique. The DI phenotyping and genotyping results were in 100% concordance. The DI*A and DI*B allele frequencies among 1,011 Central Thais were 0.0183 (37/2,022) and 0.9817 (1,985/2,022), respectively. Allele frequencies were compared between Central Thai and other populations. Our data shows that DI*A and DI*B allele frequencies are similar to Southeast Asian, Brazilian, Southern Brazilian and American Native populations; whereas, these frequencies significantly differ from those reported in East Asian, Italian, Alaska Native/Aleut, Hawaiian/Pacific Islander and Filipino populations (P<0.05), corresponding to the results of a matrix of geometric genetic distances. This study confirms that the prevalence of DI*A and DI*B alleles among Central Thais is similar to Southeast Asians and different to others populations of the world. A PCR-based identification of DI genotyping should overcome some of the serological limitations in transfusion medicine and provides a complementary tool for further population-genetic studies. |
format |
Text |
author |
Nathalang, Oytip Panichrum, Puangpaka Intharanut, Kamphon Thattanon, Phatchira Nathalang, Siriporn |
author_facet |
Nathalang, Oytip Panichrum, Puangpaka Intharanut, Kamphon Thattanon, Phatchira Nathalang, Siriporn |
author_sort |
Nathalang, Oytip |
title |
Distribution of DI*A and DI*B Allele Frequencies and Comparisons among Central Thai and Other Populations |
title_short |
Distribution of DI*A and DI*B Allele Frequencies and Comparisons among Central Thai and Other Populations |
title_full |
Distribution of DI*A and DI*B Allele Frequencies and Comparisons among Central Thai and Other Populations |
title_fullStr |
Distribution of DI*A and DI*B Allele Frequencies and Comparisons among Central Thai and Other Populations |
title_full_unstemmed |
Distribution of DI*A and DI*B Allele Frequencies and Comparisons among Central Thai and Other Populations |
title_sort |
distribution of di*a and di*b allele frequencies and comparisons among central thai and other populations |
publisher |
Public Library of Science |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072727/ http://www.ncbi.nlm.nih.gov/pubmed/27764238 https://doi.org/10.1371/journal.pone.0165134 |
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Pacific |
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Pacific |
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aleut Alaska |
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aleut Alaska |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072727/ http://www.ncbi.nlm.nih.gov/pubmed/27764238 http://dx.doi.org/10.1371/journal.pone.0165134 |
op_rights |
© 2016 Nathalang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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CC-BY |
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https://doi.org/10.1371/journal.pone.0165134 |
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