Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland
There has been limited knowledge on spatio-temporal epidemiology of zoonotic arctic fox rabies among countries bordering the Arctic, in particular Greenland. Previous molecular epidemiological studies have suggested the occurrence of one particular arctic rabies virus (RABV) lineage (arctic-3), but...
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ftpubmed:oai:pubmedcentral.nih.gov:4961414 2023-05-15T14:31:09+02:00 Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland Hanke, Dennis Freuling, Conrad M. Fischer, Susanne Hueffer, Karsten Hundertmark, Kris Nadin-Davis, Susan Marston, Denise Fooks, Anthony R. Bøtner, Anette Mettenleiter, Thomas C. Beer, Martin Rasmussen, Thomas B. Müller, Thomas F. Höper, Dirk 2016-07-26 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961414/ http://www.ncbi.nlm.nih.gov/pubmed/27459154 https://doi.org/10.1371/journal.pntd.0004779 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961414/ http://www.ncbi.nlm.nih.gov/pubmed/27459154 http://dx.doi.org/10.1371/journal.pntd.0004779 © 2016 Hanke et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2016 ftpubmed https://doi.org/10.1371/journal.pntd.0004779 2016-08-14T00:07:39Z There has been limited knowledge on spatio-temporal epidemiology of zoonotic arctic fox rabies among countries bordering the Arctic, in particular Greenland. Previous molecular epidemiological studies have suggested the occurrence of one particular arctic rabies virus (RABV) lineage (arctic-3), but have been limited by a low number of available samples preventing in-depth high resolution phylogenetic analysis of RABVs at that time. However, an improved knowledge of the evolution, at a molecular level, of the circulating RABVs and a better understanding of the historical perspective of the disease in Greenland is necessary for better direct control measures on the island. These issues have been addressed by investigating the spatio-temporal genetic diversity of arctic RABVs and their reservoir host, the arctic fox, in Greenland using both full and partial genome sequences. Using a unique set of 79 arctic RABV full genome sequences from Greenland, Canada, USA (Alaska) and Russia obtained between 1977 and 2014, a description of the historic context in relation to the genetic diversity of currently circulating RABV in Greenland and neighboring Canadian Northern territories has been provided. The phylogenetic analysis confirmed delineation into four major arctic RABV lineages (arctic 1–4) with viruses from Greenland exclusively grouping into the circumpolar arctic-3 lineage. High resolution analysis enabled distinction of seven geographically distinct subclades (3.I – 3.VII) with two subclades containing viruses from both Greenland and Canada. By combining analysis of full length RABV genome sequences and host derived sequences encoding mitochondrial proteins obtained simultaneously from brain tissues of 49 arctic foxes, the interaction of viruses and their hosts was explored in detail. Such an approach can serve as a blueprint for analysis of infectious disease dynamics and virus-host interdependencies. The results showed a fine-scale spatial population structure in Greenland arctic foxes based on mitochondrial ... Text Arctic Fox Arctic Greenland Alaska PubMed Central (PMC) Arctic Canada Greenland PLOS Neglected Tropical Diseases 10 7 e0004779 |
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PubMed Central (PMC) |
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English |
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Research Article |
spellingShingle |
Research Article Hanke, Dennis Freuling, Conrad M. Fischer, Susanne Hueffer, Karsten Hundertmark, Kris Nadin-Davis, Susan Marston, Denise Fooks, Anthony R. Bøtner, Anette Mettenleiter, Thomas C. Beer, Martin Rasmussen, Thomas B. Müller, Thomas F. Höper, Dirk Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland |
topic_facet |
Research Article |
description |
There has been limited knowledge on spatio-temporal epidemiology of zoonotic arctic fox rabies among countries bordering the Arctic, in particular Greenland. Previous molecular epidemiological studies have suggested the occurrence of one particular arctic rabies virus (RABV) lineage (arctic-3), but have been limited by a low number of available samples preventing in-depth high resolution phylogenetic analysis of RABVs at that time. However, an improved knowledge of the evolution, at a molecular level, of the circulating RABVs and a better understanding of the historical perspective of the disease in Greenland is necessary for better direct control measures on the island. These issues have been addressed by investigating the spatio-temporal genetic diversity of arctic RABVs and their reservoir host, the arctic fox, in Greenland using both full and partial genome sequences. Using a unique set of 79 arctic RABV full genome sequences from Greenland, Canada, USA (Alaska) and Russia obtained between 1977 and 2014, a description of the historic context in relation to the genetic diversity of currently circulating RABV in Greenland and neighboring Canadian Northern territories has been provided. The phylogenetic analysis confirmed delineation into four major arctic RABV lineages (arctic 1–4) with viruses from Greenland exclusively grouping into the circumpolar arctic-3 lineage. High resolution analysis enabled distinction of seven geographically distinct subclades (3.I – 3.VII) with two subclades containing viruses from both Greenland and Canada. By combining analysis of full length RABV genome sequences and host derived sequences encoding mitochondrial proteins obtained simultaneously from brain tissues of 49 arctic foxes, the interaction of viruses and their hosts was explored in detail. Such an approach can serve as a blueprint for analysis of infectious disease dynamics and virus-host interdependencies. The results showed a fine-scale spatial population structure in Greenland arctic foxes based on mitochondrial ... |
format |
Text |
author |
Hanke, Dennis Freuling, Conrad M. Fischer, Susanne Hueffer, Karsten Hundertmark, Kris Nadin-Davis, Susan Marston, Denise Fooks, Anthony R. Bøtner, Anette Mettenleiter, Thomas C. Beer, Martin Rasmussen, Thomas B. Müller, Thomas F. Höper, Dirk |
author_facet |
Hanke, Dennis Freuling, Conrad M. Fischer, Susanne Hueffer, Karsten Hundertmark, Kris Nadin-Davis, Susan Marston, Denise Fooks, Anthony R. Bøtner, Anette Mettenleiter, Thomas C. Beer, Martin Rasmussen, Thomas B. Müller, Thomas F. Höper, Dirk |
author_sort |
Hanke, Dennis |
title |
Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland |
title_short |
Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland |
title_full |
Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland |
title_fullStr |
Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland |
title_full_unstemmed |
Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland |
title_sort |
spatio-temporal analysis of the genetic diversity of arctic rabies viruses and their reservoir hosts in greenland |
publisher |
Public Library of Science |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961414/ http://www.ncbi.nlm.nih.gov/pubmed/27459154 https://doi.org/10.1371/journal.pntd.0004779 |
geographic |
Arctic Canada Greenland |
geographic_facet |
Arctic Canada Greenland |
genre |
Arctic Fox Arctic Greenland Alaska |
genre_facet |
Arctic Fox Arctic Greenland Alaska |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961414/ http://www.ncbi.nlm.nih.gov/pubmed/27459154 http://dx.doi.org/10.1371/journal.pntd.0004779 |
op_rights |
© 2016 Hanke et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pntd.0004779 |
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PLOS Neglected Tropical Diseases |
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7 |
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e0004779 |
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