Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a relatively rare condition (1/1000–1/2000) that was granted orphan status by the European Medicines Agency in 2011. Clinical consequences of FNAIT, however, may be severe. A thrombocytopenic fetus or new-born is at risk of intracranial hemorrhag...
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ftpubmed:oai:pubmedcentral.nih.gov:4939163 2023-05-15T18:49:26+02:00 Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention Brojer, Ewa Husebekk, Anne Dębska, Marzena Uhrynowska, Małgorzata Guz, Katarzyna Orzińska, Agnieszka Dębski, Romuald Maślanka, Krystyna 2015-11-12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939163/ http://www.ncbi.nlm.nih.gov/pubmed/26564154 https://doi.org/10.1007/s00005-015-0371-9 en eng Springer International Publishing http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939163/ http://www.ncbi.nlm.nih.gov/pubmed/26564154 http://dx.doi.org/10.1007/s00005-015-0371-9 © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. CC-BY Review Text 2015 ftpubmed https://doi.org/10.1007/s00005-015-0371-9 2016-07-24T00:10:26Z Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a relatively rare condition (1/1000–1/2000) that was granted orphan status by the European Medicines Agency in 2011. Clinical consequences of FNAIT, however, may be severe. A thrombocytopenic fetus or new-born is at risk of intracranial hemorrhage that may result in lifelong disability or death. Preventing such bleeding is thus vital and requires a solution. Anti-HPA1a antibodies are the most frequent cause of FNAIT in Caucasians. Its pathogenesis is similar to hemolytic disease of the newborn (HDN) due to anti-RhD antibodies, but is characterized by platelet destruction and is more often observed in the first pregnancy. In 75 % of these women, alloimmunization by HPA-1a antigens, however, occurs at delivery, which enables development of antibody-mediated immune suppression to prevent maternal immunization. As for HDN, the recurrence rate of FNAIT is high. For advancing diagnostic efforts and treatment, it is thereby crucial to understand the pathogenesis of FNAIT, including cellular immunity involvement. This review presents the current knowledge on FNAIT. Also described is a program for HPA-1a screening in identifying HPA-1a negative pregnant women at risk of immunization. This program is now performed at the Institute of Hematology and Transfusion Medicine in cooperation with the Department of Obstetrics and Gynecology of the Medical Centre of Postgraduate Education in Warsaw as well as the UiT The Arctic University of Norway. Text Arctic University of Norway UiT The Arctic University of Norway PubMed Central (PMC) Arctic Norway Archivum Immunologiae et Therapiae Experimentalis 64 4 279 290 |
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Review Brojer, Ewa Husebekk, Anne Dębska, Marzena Uhrynowska, Małgorzata Guz, Katarzyna Orzińska, Agnieszka Dębski, Romuald Maślanka, Krystyna Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention |
topic_facet |
Review |
description |
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a relatively rare condition (1/1000–1/2000) that was granted orphan status by the European Medicines Agency in 2011. Clinical consequences of FNAIT, however, may be severe. A thrombocytopenic fetus or new-born is at risk of intracranial hemorrhage that may result in lifelong disability or death. Preventing such bleeding is thus vital and requires a solution. Anti-HPA1a antibodies are the most frequent cause of FNAIT in Caucasians. Its pathogenesis is similar to hemolytic disease of the newborn (HDN) due to anti-RhD antibodies, but is characterized by platelet destruction and is more often observed in the first pregnancy. In 75 % of these women, alloimmunization by HPA-1a antigens, however, occurs at delivery, which enables development of antibody-mediated immune suppression to prevent maternal immunization. As for HDN, the recurrence rate of FNAIT is high. For advancing diagnostic efforts and treatment, it is thereby crucial to understand the pathogenesis of FNAIT, including cellular immunity involvement. This review presents the current knowledge on FNAIT. Also described is a program for HPA-1a screening in identifying HPA-1a negative pregnant women at risk of immunization. This program is now performed at the Institute of Hematology and Transfusion Medicine in cooperation with the Department of Obstetrics and Gynecology of the Medical Centre of Postgraduate Education in Warsaw as well as the UiT The Arctic University of Norway. |
format |
Text |
author |
Brojer, Ewa Husebekk, Anne Dębska, Marzena Uhrynowska, Małgorzata Guz, Katarzyna Orzińska, Agnieszka Dębski, Romuald Maślanka, Krystyna |
author_facet |
Brojer, Ewa Husebekk, Anne Dębska, Marzena Uhrynowska, Małgorzata Guz, Katarzyna Orzińska, Agnieszka Dębski, Romuald Maślanka, Krystyna |
author_sort |
Brojer, Ewa |
title |
Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention |
title_short |
Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention |
title_full |
Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention |
title_fullStr |
Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention |
title_full_unstemmed |
Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention |
title_sort |
fetal/neonatal alloimmune thrombocytopenia: pathogenesis, diagnostics and prevention |
publisher |
Springer International Publishing |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939163/ http://www.ncbi.nlm.nih.gov/pubmed/26564154 https://doi.org/10.1007/s00005-015-0371-9 |
geographic |
Arctic Norway |
geographic_facet |
Arctic Norway |
genre |
Arctic University of Norway UiT The Arctic University of Norway |
genre_facet |
Arctic University of Norway UiT The Arctic University of Norway |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939163/ http://www.ncbi.nlm.nih.gov/pubmed/26564154 http://dx.doi.org/10.1007/s00005-015-0371-9 |
op_rights |
© The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s00005-015-0371-9 |
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Archivum Immunologiae et Therapiae Experimentalis |
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64 |
container_issue |
4 |
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279 |
op_container_end_page |
290 |
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1766243026991054848 |