Experimental infection and pathology of clade 2.2 H5N1 virus in gulls
During 2006, H5N1 HPAI caused an epizootic in wild birds, resulting in a die-off of Laridae in the Novosibirsk region at Chany Lake. In the present study, we infected common gulls (Larus canus) with a high dose of the H5N1 HPAI virus isolated from a common gull to determine if severe disease could b...
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ftpubmed:oai:pubmedcentral.nih.gov:4921666 2023-05-15T17:07:22+02:00 Experimental infection and pathology of clade 2.2 H5N1 virus in gulls Gulyaeva, Marina A. Sharshov, Kirill A. Zaykovskaia, Anna V. Shestopalova, Lidia V. Shestopalov, Aleksander M. 2016-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921666/ http://www.ncbi.nlm.nih.gov/pubmed/26243601 https://doi.org/10.4142/jvs.2016.17.2.179 en eng The Korean Society of Veterinary Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921666/ http://www.ncbi.nlm.nih.gov/pubmed/26243601 http://dx.doi.org/10.4142/jvs.2016.17.2.179 © 2016 The Korean Society of Veterinary Science. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY-NC Original Article Text 2016 ftpubmed https://doi.org/10.4142/jvs.2016.17.2.179 2016-07-03T00:27:38Z During 2006, H5N1 HPAI caused an epizootic in wild birds, resulting in a die-off of Laridae in the Novosibirsk region at Chany Lake. In the present study, we infected common gulls (Larus canus) with a high dose of the H5N1 HPAI virus isolated from a common gull to determine if severe disease could be induced over the 28 day experimental period. Moderate clinical signs including diarrhea, conjunctivitis, respiratory distress and neurological signs were observed in virus-inoculated birds, and 50% died. The most common microscopic lesions observed were necrosis of the pancreas, mild encephalitis, mild myocarditis, liver parenchymal hemorrhages, lymphocytic hepatitis, parabronchi lumen hemorrhages and interstitial pneumonia. High viral titers were shed from the oropharyngeal route and virus was still detected in one bird at 25 days after infection. In the cloaca, the virus was detected sporadically in lower titers. The virus was transmitted to direct contact gulls. Thus, infected gulls can pose a significant risk of H5N1 HPAIV transmission to other wild migratory waterfowl and pose a risk to more susceptible poultry species. These findings have important implications regarding the mode of transmission and potential risks of H5N1 HPAI spread by gulls. Text Larus canus PubMed Central (PMC) Journal of Veterinary Science 17 2 179 |
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Original Article Gulyaeva, Marina A. Sharshov, Kirill A. Zaykovskaia, Anna V. Shestopalova, Lidia V. Shestopalov, Aleksander M. Experimental infection and pathology of clade 2.2 H5N1 virus in gulls |
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Original Article |
description |
During 2006, H5N1 HPAI caused an epizootic in wild birds, resulting in a die-off of Laridae in the Novosibirsk region at Chany Lake. In the present study, we infected common gulls (Larus canus) with a high dose of the H5N1 HPAI virus isolated from a common gull to determine if severe disease could be induced over the 28 day experimental period. Moderate clinical signs including diarrhea, conjunctivitis, respiratory distress and neurological signs were observed in virus-inoculated birds, and 50% died. The most common microscopic lesions observed were necrosis of the pancreas, mild encephalitis, mild myocarditis, liver parenchymal hemorrhages, lymphocytic hepatitis, parabronchi lumen hemorrhages and interstitial pneumonia. High viral titers were shed from the oropharyngeal route and virus was still detected in one bird at 25 days after infection. In the cloaca, the virus was detected sporadically in lower titers. The virus was transmitted to direct contact gulls. Thus, infected gulls can pose a significant risk of H5N1 HPAIV transmission to other wild migratory waterfowl and pose a risk to more susceptible poultry species. These findings have important implications regarding the mode of transmission and potential risks of H5N1 HPAI spread by gulls. |
format |
Text |
author |
Gulyaeva, Marina A. Sharshov, Kirill A. Zaykovskaia, Anna V. Shestopalova, Lidia V. Shestopalov, Aleksander M. |
author_facet |
Gulyaeva, Marina A. Sharshov, Kirill A. Zaykovskaia, Anna V. Shestopalova, Lidia V. Shestopalov, Aleksander M. |
author_sort |
Gulyaeva, Marina A. |
title |
Experimental infection and pathology of clade 2.2 H5N1 virus in gulls |
title_short |
Experimental infection and pathology of clade 2.2 H5N1 virus in gulls |
title_full |
Experimental infection and pathology of clade 2.2 H5N1 virus in gulls |
title_fullStr |
Experimental infection and pathology of clade 2.2 H5N1 virus in gulls |
title_full_unstemmed |
Experimental infection and pathology of clade 2.2 H5N1 virus in gulls |
title_sort |
experimental infection and pathology of clade 2.2 h5n1 virus in gulls |
publisher |
The Korean Society of Veterinary Science |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921666/ http://www.ncbi.nlm.nih.gov/pubmed/26243601 https://doi.org/10.4142/jvs.2016.17.2.179 |
genre |
Larus canus |
genre_facet |
Larus canus |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921666/ http://www.ncbi.nlm.nih.gov/pubmed/26243601 http://dx.doi.org/10.4142/jvs.2016.17.2.179 |
op_rights |
© 2016 The Korean Society of Veterinary Science. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.4142/jvs.2016.17.2.179 |
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Journal of Veterinary Science |
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17 |
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2 |
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179 |
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1766062753280163840 |