Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik
The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF...
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ftpubmed:oai:pubmedcentral.nih.gov:4921626 2023-05-15T16:54:54+02:00 Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik Turgeon O'Brien, Huguette Blanchet, Rosanne Gagné, Doris Lauzière, Julie Vézina, Carole 2016 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921626/ http://www.ncbi.nlm.nih.gov/pubmed/27382488 https://doi.org/10.1155/2016/6430214 en eng Hindawi Publishing Corporation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921626/ http://www.ncbi.nlm.nih.gov/pubmed/27382488 http://dx.doi.org/10.1155/2016/6430214 Copyright © 2016 Huguette Turgeon O'Brien et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Research Article Text 2016 ftpubmed https://doi.org/10.1155/2016/6430214 2016-07-10T00:11:39Z The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF cutoffs. Iron depletion was defined as follows: (1) SF < 15 μg/L regardless of the C-reactive protein (CRP) level and (2) SF < 15 or <50 μg/L with CRP ≤ 5 or >5 mg/L, respectively. IDE corresponded to iron depletion combined with total iron binding capacity > 72 μmol/L and/or transferrin saturation < 16%. Iron depletion and IDE affected almost half of the children when accounting for inflammation, compared to one-third when the SF cutoff was defined regardless of CRP level (P < 0.0001). The prevalence of IDE adjusted for inflammation (45.1%) was very similar to the prevalence observed when sTfR was used as a sole marker of IDE (47.4%). The prevalence of anemia was 15%. The prevalence of IDA (IDE + hemoglobin < 110 g/L) was higher when accounting for than when disregarding inflammation (8.0% versus 6.2%, P = 0.083). Using sTfR and different SF cutoffs for children with versus without inflammation improved the diagnosis of iron depletion and IDE. Our results confirm that Inuit children are at particularly high risk for iron deficiency. Text inuit Nunavik PubMed Central (PMC) Ida ENVELOPE(170.483,170.483,-83.583,-83.583) Nunavik Anemia 2016 1 10 |
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Research Article |
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Research Article Turgeon O'Brien, Huguette Blanchet, Rosanne Gagné, Doris Lauzière, Julie Vézina, Carole Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik |
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Research Article |
description |
The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF cutoffs. Iron depletion was defined as follows: (1) SF < 15 μg/L regardless of the C-reactive protein (CRP) level and (2) SF < 15 or <50 μg/L with CRP ≤ 5 or >5 mg/L, respectively. IDE corresponded to iron depletion combined with total iron binding capacity > 72 μmol/L and/or transferrin saturation < 16%. Iron depletion and IDE affected almost half of the children when accounting for inflammation, compared to one-third when the SF cutoff was defined regardless of CRP level (P < 0.0001). The prevalence of IDE adjusted for inflammation (45.1%) was very similar to the prevalence observed when sTfR was used as a sole marker of IDE (47.4%). The prevalence of anemia was 15%. The prevalence of IDA (IDE + hemoglobin < 110 g/L) was higher when accounting for than when disregarding inflammation (8.0% versus 6.2%, P = 0.083). Using sTfR and different SF cutoffs for children with versus without inflammation improved the diagnosis of iron depletion and IDE. Our results confirm that Inuit children are at particularly high risk for iron deficiency. |
format |
Text |
author |
Turgeon O'Brien, Huguette Blanchet, Rosanne Gagné, Doris Lauzière, Julie Vézina, Carole |
author_facet |
Turgeon O'Brien, Huguette Blanchet, Rosanne Gagné, Doris Lauzière, Julie Vézina, Carole |
author_sort |
Turgeon O'Brien, Huguette |
title |
Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik |
title_short |
Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik |
title_full |
Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik |
title_fullStr |
Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik |
title_full_unstemmed |
Using Soluble Transferrin Receptor and Taking Inflammation into Account When Defining Serum Ferritin Cutoffs Improved the Diagnosis of Iron Deficiency in a Group of Canadian Preschool Inuit Children from Nunavik |
title_sort |
using soluble transferrin receptor and taking inflammation into account when defining serum ferritin cutoffs improved the diagnosis of iron deficiency in a group of canadian preschool inuit children from nunavik |
publisher |
Hindawi Publishing Corporation |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921626/ http://www.ncbi.nlm.nih.gov/pubmed/27382488 https://doi.org/10.1155/2016/6430214 |
long_lat |
ENVELOPE(170.483,170.483,-83.583,-83.583) |
geographic |
Ida Nunavik |
geographic_facet |
Ida Nunavik |
genre |
inuit Nunavik |
genre_facet |
inuit Nunavik |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921626/ http://www.ncbi.nlm.nih.gov/pubmed/27382488 http://dx.doi.org/10.1155/2016/6430214 |
op_rights |
Copyright © 2016 Huguette Turgeon O'Brien et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1155/2016/6430214 |
container_title |
Anemia |
container_volume |
2016 |
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1 |
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10 |
_version_ |
1766045830402277376 |