The Prehistory of Antibiotic Resistance
Antibiotic resistance is a global problem that is reaching crisis levels. The global collection of resistance genes in clinical and environmental samples is the antibiotic “resistome,” and is subject to the selective pressure of human activity. The origin of many modern resistance genes in pathogens...
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ftpubmed:oai:pubmedcentral.nih.gov:4888810 2023-05-15T17:57:33+02:00 The Prehistory of Antibiotic Resistance Perry, Julie Waglechner, Nicholas Wright, Gerard 2016-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888810/ http://www.ncbi.nlm.nih.gov/pubmed/27252395 https://doi.org/10.1101/cshperspect.a025197 en eng Cold Spring Harbor Laboratory Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888810/ http://www.ncbi.nlm.nih.gov/pubmed/27252395 http://dx.doi.org/10.1101/cshperspect.a025197 Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved Perspectives Text 2016 ftpubmed https://doi.org/10.1101/cshperspect.a025197 2018-06-03T00:05:47Z Antibiotic resistance is a global problem that is reaching crisis levels. The global collection of resistance genes in clinical and environmental samples is the antibiotic “resistome,” and is subject to the selective pressure of human activity. The origin of many modern resistance genes in pathogens is likely environmental bacteria, including antibiotic producing organisms that have existed for millennia. Recent work has uncovered resistance in ancient permafrost, isolated caves, and in human specimens preserved for hundreds of years. Together with bioinformatic analyses on modern-day sequences, these studies predict an ancient origin of resistance that long precedes the use of antibiotics in the clinic. Understanding the history of antibiotic resistance is important in predicting its future evolution. Text permafrost PubMed Central (PMC) Cold Spring Harbor Perspectives in Medicine 6 6 a025197 |
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Perspectives Perry, Julie Waglechner, Nicholas Wright, Gerard The Prehistory of Antibiotic Resistance |
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Antibiotic resistance is a global problem that is reaching crisis levels. The global collection of resistance genes in clinical and environmental samples is the antibiotic “resistome,” and is subject to the selective pressure of human activity. The origin of many modern resistance genes in pathogens is likely environmental bacteria, including antibiotic producing organisms that have existed for millennia. Recent work has uncovered resistance in ancient permafrost, isolated caves, and in human specimens preserved for hundreds of years. Together with bioinformatic analyses on modern-day sequences, these studies predict an ancient origin of resistance that long precedes the use of antibiotics in the clinic. Understanding the history of antibiotic resistance is important in predicting its future evolution. |
format |
Text |
author |
Perry, Julie Waglechner, Nicholas Wright, Gerard |
author_facet |
Perry, Julie Waglechner, Nicholas Wright, Gerard |
author_sort |
Perry, Julie |
title |
The Prehistory of Antibiotic Resistance |
title_short |
The Prehistory of Antibiotic Resistance |
title_full |
The Prehistory of Antibiotic Resistance |
title_fullStr |
The Prehistory of Antibiotic Resistance |
title_full_unstemmed |
The Prehistory of Antibiotic Resistance |
title_sort |
prehistory of antibiotic resistance |
publisher |
Cold Spring Harbor Laboratory Press |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888810/ http://www.ncbi.nlm.nih.gov/pubmed/27252395 https://doi.org/10.1101/cshperspect.a025197 |
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permafrost |
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permafrost |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888810/ http://www.ncbi.nlm.nih.gov/pubmed/27252395 http://dx.doi.org/10.1101/cshperspect.a025197 |
op_rights |
Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved |
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https://doi.org/10.1101/cshperspect.a025197 |
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Cold Spring Harbor Perspectives in Medicine |
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6 |
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6 |
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a025197 |
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1766166001527816192 |