Cryotherapy-Induced Persistent Vasoconstriction After Cutaneous Cooling: Hysteresis Between Skin Temperature and Blood Perfusion
The goal of this study was to investigate the persistence of cold-induced vasoconstriction following cessation of active skin-surface cooling. This study demonstrates a hysteresis effect that develops between skin temperature and blood perfusion during the cooling and subsequent rewarming period. An...
Published in: | Journal of Biomechanical Engineering |
---|---|
Main Authors: | , , , |
Format: | Text |
Language: | English |
Published: |
American Society of Mechanical Engineers
2016
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844090/ http://www.ncbi.nlm.nih.gov/pubmed/26632263 https://doi.org/10.1115/1.4032126 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:4844090 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:4844090 2023-05-15T15:08:15+02:00 Cryotherapy-Induced Persistent Vasoconstriction After Cutaneous Cooling: Hysteresis Between Skin Temperature and Blood Perfusion Khoshnevis, Sepideh Craik, Natalie K. Matthew Brothers, R. Diller, Kenneth R. 2016-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844090/ http://www.ncbi.nlm.nih.gov/pubmed/26632263 https://doi.org/10.1115/1.4032126 en eng American Society of Mechanical Engineers http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844090/ http://www.ncbi.nlm.nih.gov/pubmed/26632263 http://dx.doi.org/10.1115/1.4032126 Copyright © 2016 by ASME 0148-0731/2016/138(3)/031004/8/$25.00 Research Papers Text 2016 ftpubmed https://doi.org/10.1115/1.4032126 2017-03-05T01:11:42Z The goal of this study was to investigate the persistence of cold-induced vasoconstriction following cessation of active skin-surface cooling. This study demonstrates a hysteresis effect that develops between skin temperature and blood perfusion during the cooling and subsequent rewarming period. An Arctic Ice cryotherapy unit (CTU) was applied to the knee region of six healthy subjects for 60 min of active cooling followed by 120 min of passive rewarming. Multiple laser Doppler flowmetry perfusion probes were used to measure skin blood flow (expressed as cutaneous vascular conductance (CVC)). Skin surface cooling produced a significant reduction in CVC (P < 0.001) that persisted throughout the duration of the rewarming period. In addition, there was a hysteresis effect between CVC and skin temperature during the cooling and subsequent rewarming cycle (P < 0.01). Mixed model regression (MMR) showed a significant difference in the slopes of the CVC–skin temperature curves during cooling and rewarming (P < 0.001). Piecewise regression was used to investigate the temperature thresholds for acceleration of CVC during the cooling and rewarming periods. The two thresholds were shown to be significantly different (P = 0.003). The results show that localized cooling causes significant vasoconstriction that continues beyond the active cooling period despite skin temperatures returning toward baseline values. The significant and persistent reduction in skin perfusion may contribute to nonfreezing cold injury (NFCI) associated with cryotherapy. Text Arctic PubMed Central (PMC) Arctic Journal of Biomechanical Engineering 138 3 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Research Papers |
spellingShingle |
Research Papers Khoshnevis, Sepideh Craik, Natalie K. Matthew Brothers, R. Diller, Kenneth R. Cryotherapy-Induced Persistent Vasoconstriction After Cutaneous Cooling: Hysteresis Between Skin Temperature and Blood Perfusion |
topic_facet |
Research Papers |
description |
The goal of this study was to investigate the persistence of cold-induced vasoconstriction following cessation of active skin-surface cooling. This study demonstrates a hysteresis effect that develops between skin temperature and blood perfusion during the cooling and subsequent rewarming period. An Arctic Ice cryotherapy unit (CTU) was applied to the knee region of six healthy subjects for 60 min of active cooling followed by 120 min of passive rewarming. Multiple laser Doppler flowmetry perfusion probes were used to measure skin blood flow (expressed as cutaneous vascular conductance (CVC)). Skin surface cooling produced a significant reduction in CVC (P < 0.001) that persisted throughout the duration of the rewarming period. In addition, there was a hysteresis effect between CVC and skin temperature during the cooling and subsequent rewarming cycle (P < 0.01). Mixed model regression (MMR) showed a significant difference in the slopes of the CVC–skin temperature curves during cooling and rewarming (P < 0.001). Piecewise regression was used to investigate the temperature thresholds for acceleration of CVC during the cooling and rewarming periods. The two thresholds were shown to be significantly different (P = 0.003). The results show that localized cooling causes significant vasoconstriction that continues beyond the active cooling period despite skin temperatures returning toward baseline values. The significant and persistent reduction in skin perfusion may contribute to nonfreezing cold injury (NFCI) associated with cryotherapy. |
format |
Text |
author |
Khoshnevis, Sepideh Craik, Natalie K. Matthew Brothers, R. Diller, Kenneth R. |
author_facet |
Khoshnevis, Sepideh Craik, Natalie K. Matthew Brothers, R. Diller, Kenneth R. |
author_sort |
Khoshnevis, Sepideh |
title |
Cryotherapy-Induced Persistent Vasoconstriction After Cutaneous Cooling: Hysteresis Between Skin Temperature and Blood Perfusion |
title_short |
Cryotherapy-Induced Persistent Vasoconstriction After Cutaneous Cooling: Hysteresis Between Skin Temperature and Blood Perfusion |
title_full |
Cryotherapy-Induced Persistent Vasoconstriction After Cutaneous Cooling: Hysteresis Between Skin Temperature and Blood Perfusion |
title_fullStr |
Cryotherapy-Induced Persistent Vasoconstriction After Cutaneous Cooling: Hysteresis Between Skin Temperature and Blood Perfusion |
title_full_unstemmed |
Cryotherapy-Induced Persistent Vasoconstriction After Cutaneous Cooling: Hysteresis Between Skin Temperature and Blood Perfusion |
title_sort |
cryotherapy-induced persistent vasoconstriction after cutaneous cooling: hysteresis between skin temperature and blood perfusion |
publisher |
American Society of Mechanical Engineers |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844090/ http://www.ncbi.nlm.nih.gov/pubmed/26632263 https://doi.org/10.1115/1.4032126 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844090/ http://www.ncbi.nlm.nih.gov/pubmed/26632263 http://dx.doi.org/10.1115/1.4032126 |
op_rights |
Copyright © 2016 by ASME 0148-0731/2016/138(3)/031004/8/$25.00 |
op_doi |
https://doi.org/10.1115/1.4032126 |
container_title |
Journal of Biomechanical Engineering |
container_volume |
138 |
container_issue |
3 |
_version_ |
1766339642122043392 |