Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland
Over the last 10 years substantial progress has been made in our understanding of the genetic basis for type 2 diabetes and related traits. These developments have been facilitated by technological advancements that have allowed comprehensive genome-wide assessments of the impact of common genetic v...
Published in: | Diabetologia |
---|---|
Main Authors: | , , |
Format: | Text |
Language: | English |
Published: |
Springer Berlin Heidelberg
2016
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826421/ http://www.ncbi.nlm.nih.gov/pubmed/26993633 https://doi.org/10.1007/s00125-016-3926-3 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:4826421 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:4826421 2023-05-15T16:27:14+02:00 Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland Zeggini, Eleftheria Gloyn, Anna L. Hansen, Torben 2016-03-18 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826421/ http://www.ncbi.nlm.nih.gov/pubmed/26993633 https://doi.org/10.1007/s00125-016-3926-3 en eng Springer Berlin Heidelberg http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826421/ http://www.ncbi.nlm.nih.gov/pubmed/26993633 http://dx.doi.org/10.1007/s00125-016-3926-3 © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. CC-BY Review Text 2016 ftpubmed https://doi.org/10.1007/s00125-016-3926-3 2016-04-24T00:10:35Z Over the last 10 years substantial progress has been made in our understanding of the genetic basis for type 2 diabetes and related traits. These developments have been facilitated by technological advancements that have allowed comprehensive genome-wide assessments of the impact of common genetic variation on disease risk. Current efforts are now focused on extending this to genetic variants in the rare and low-frequency spectrum by capitalising on next-generation sequencing technologies. This review discusses the important contributions that studies in isolated populations are making to this effort for diabetes and metabolic disease, drawing on specific examples from populations in Greece and Greenland. This review summarises a presentation given at the ‘Exciting news in genetics of diabetes’ symposium at the 2015 annual meeting of the EASD, with topics presented by Eleftheria Zeggini and Torben Hansen, and an overview by the Session Chair, Anna Gloyn. Text Greenland PubMed Central (PMC) Greenland Diabetologia 59 5 938 941 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Review |
spellingShingle |
Review Zeggini, Eleftheria Gloyn, Anna L. Hansen, Torben Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland |
topic_facet |
Review |
description |
Over the last 10 years substantial progress has been made in our understanding of the genetic basis for type 2 diabetes and related traits. These developments have been facilitated by technological advancements that have allowed comprehensive genome-wide assessments of the impact of common genetic variation on disease risk. Current efforts are now focused on extending this to genetic variants in the rare and low-frequency spectrum by capitalising on next-generation sequencing technologies. This review discusses the important contributions that studies in isolated populations are making to this effort for diabetes and metabolic disease, drawing on specific examples from populations in Greece and Greenland. This review summarises a presentation given at the ‘Exciting news in genetics of diabetes’ symposium at the 2015 annual meeting of the EASD, with topics presented by Eleftheria Zeggini and Torben Hansen, and an overview by the Session Chair, Anna Gloyn. |
format |
Text |
author |
Zeggini, Eleftheria Gloyn, Anna L. Hansen, Torben |
author_facet |
Zeggini, Eleftheria Gloyn, Anna L. Hansen, Torben |
author_sort |
Zeggini, Eleftheria |
title |
Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland |
title_short |
Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland |
title_full |
Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland |
title_fullStr |
Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland |
title_full_unstemmed |
Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland |
title_sort |
insights into metabolic disease from studying genetics in isolated populations: stories from greece to greenland |
publisher |
Springer Berlin Heidelberg |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826421/ http://www.ncbi.nlm.nih.gov/pubmed/26993633 https://doi.org/10.1007/s00125-016-3926-3 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826421/ http://www.ncbi.nlm.nih.gov/pubmed/26993633 http://dx.doi.org/10.1007/s00125-016-3926-3 |
op_rights |
© The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s00125-016-3926-3 |
container_title |
Diabetologia |
container_volume |
59 |
container_issue |
5 |
container_start_page |
938 |
op_container_end_page |
941 |
_version_ |
1766016352539115520 |