Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1

• Published in: Marine Drugs
• Main Authors: Zhang, Liu-Qiang, Chen, Xiao-Chong, Chen, Zhao-Qiang, Wang, Gui-Min, Zhu, Shi-Guo, Yang, Yi-Fu, Chen, Kai-Xian, Liu, Xiao-Yu, Li, Yi-Ming
• Format: Text
• Language: English
• Published: MDPI 2016
• Subjects: Article; Arctic
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820298/; http://www.ncbi.nlm.nih.gov/pubmed/26959036; https://doi.org/10.3390/md14030044

Eutypenoids A–C (1–3), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass spectroscopy (MS), nuclear magnetic resonance (NMR), X-ray crystallography, and electronic circular dichroism (ECD) analysis. The immunosuppressive effects of eutypenoids A–C (1–3) were studied using a ConA-induced splenocyte proliferation model, which suggested that 2 exhibited potent immunosuppressive activities.