Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats
No comparative study could be found for the analgesic activity of mucuses from the Oncorhynchus mykiss (OM), Salvelinus fontinalis (SF), Salmo coruhensis (SC), Acipenser gueldenstaedtii (AG), and Acipenser baerii (AB) fish species in the literature. We aimed to investigate the effects of mucuses obt...
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ftpubmed:oai:pubmedcentral.nih.gov:4783653 2023-05-15T13:01:56+02:00 Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats Cetin, Nihal Suleyman, Bahtiyar Kuyrukluyildiz, Ufuk Nalkiran, Hatice Sevim Kiran, Altan Gencoglu, Songul Duzgun, Ahmet Kurtoglu, Ilker Zeki Yarali, Oguzhan Gul, Mehmet Ali Suleyman, Halis 2015-10-20 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783653/ http://www.ncbi.nlm.nih.gov/pubmed/26490740 https://doi.org/10.1538/expanim.15-0051 en eng Japanese Association for Laboratory Animal Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783653/ http://www.ncbi.nlm.nih.gov/pubmed/26490740 http://dx.doi.org/10.1538/expanim.15-0051 ©2016 Japanese Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. CC-BY-NC-ND Original Text 2015 ftpubmed https://doi.org/10.1538/expanim.15-0051 2016-03-20T01:32:25Z No comparative study could be found for the analgesic activity of mucuses from the Oncorhynchus mykiss (OM), Salvelinus fontinalis (SF), Salmo coruhensis (SC), Acipenser gueldenstaedtii (AG), and Acipenser baerii (AB) fish species in the literature. We aimed to investigate the effects of mucuses obtained from the abovementioned fish species on scalpel incision-induced pain in the rat paw and to examine the role of oxidant/antioxidant parameters and COX-2 gene expression in the analgesic activities. Animals were divided into groups: SIC (scalpel incision; SI), SIDS (SI+25 mg/kg diclofenac sodium), SOM (SI+25 mg/kg OM mucus), SFM (SI+25 mg/kg SF mucus), SCM (SI+25 mg/kg SC mucus), SAgM (SI+25 mg/kg AG mucus), SAbM (SI+25 mg/kg AB mucus), and HG (healthy). The paw pain thresholds were measured with a Basile algesimeter before and after diclofenac sodium (DS) or mucus administration, and then the rats were euthanized with thiopental sodium. Oxidant/antioxidant and COX-2 gene expression parameters were measured in paw tissues. OM, SC, AG, and AB fish mucuses could not decrease the SI-induced pain. However, SF fish mucus prevented this pain by 69% after the first hour and by 58.3% after the third hour. DS was shown to suppress pain more weakly than SF, preventing the pain by 62.1% and 50.0% after the first and third hours, respectively. SF mucus and DS significantly inhibited increase of COX-2 gene expression, while other fish mucuses could not. None of the fish mucuses except SF mucus in conjunction with DS could significantly inhibit the increase in oxidant parameters and decrease in antioxidants. SF fish mucus should be comparatively assessed in clinical practice for treatment of postoperative pain. Text Acipenser baerii PubMed Central (PMC) Experimental Animals 65 1 77 85 |
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Original Cetin, Nihal Suleyman, Bahtiyar Kuyrukluyildiz, Ufuk Nalkiran, Hatice Sevim Kiran, Altan Gencoglu, Songul Duzgun, Ahmet Kurtoglu, Ilker Zeki Yarali, Oguzhan Gul, Mehmet Ali Suleyman, Halis Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats |
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Original |
description |
No comparative study could be found for the analgesic activity of mucuses from the Oncorhynchus mykiss (OM), Salvelinus fontinalis (SF), Salmo coruhensis (SC), Acipenser gueldenstaedtii (AG), and Acipenser baerii (AB) fish species in the literature. We aimed to investigate the effects of mucuses obtained from the abovementioned fish species on scalpel incision-induced pain in the rat paw and to examine the role of oxidant/antioxidant parameters and COX-2 gene expression in the analgesic activities. Animals were divided into groups: SIC (scalpel incision; SI), SIDS (SI+25 mg/kg diclofenac sodium), SOM (SI+25 mg/kg OM mucus), SFM (SI+25 mg/kg SF mucus), SCM (SI+25 mg/kg SC mucus), SAgM (SI+25 mg/kg AG mucus), SAbM (SI+25 mg/kg AB mucus), and HG (healthy). The paw pain thresholds were measured with a Basile algesimeter before and after diclofenac sodium (DS) or mucus administration, and then the rats were euthanized with thiopental sodium. Oxidant/antioxidant and COX-2 gene expression parameters were measured in paw tissues. OM, SC, AG, and AB fish mucuses could not decrease the SI-induced pain. However, SF fish mucus prevented this pain by 69% after the first hour and by 58.3% after the third hour. DS was shown to suppress pain more weakly than SF, preventing the pain by 62.1% and 50.0% after the first and third hours, respectively. SF mucus and DS significantly inhibited increase of COX-2 gene expression, while other fish mucuses could not. None of the fish mucuses except SF mucus in conjunction with DS could significantly inhibit the increase in oxidant parameters and decrease in antioxidants. SF fish mucus should be comparatively assessed in clinical practice for treatment of postoperative pain. |
format |
Text |
author |
Cetin, Nihal Suleyman, Bahtiyar Kuyrukluyildiz, Ufuk Nalkiran, Hatice Sevim Kiran, Altan Gencoglu, Songul Duzgun, Ahmet Kurtoglu, Ilker Zeki Yarali, Oguzhan Gul, Mehmet Ali Suleyman, Halis |
author_facet |
Cetin, Nihal Suleyman, Bahtiyar Kuyrukluyildiz, Ufuk Nalkiran, Hatice Sevim Kiran, Altan Gencoglu, Songul Duzgun, Ahmet Kurtoglu, Ilker Zeki Yarali, Oguzhan Gul, Mehmet Ali Suleyman, Halis |
author_sort |
Cetin, Nihal |
title |
Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats |
title_short |
Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats |
title_full |
Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats |
title_fullStr |
Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats |
title_full_unstemmed |
Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats |
title_sort |
investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats |
publisher |
Japanese Association for Laboratory Animal Science |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783653/ http://www.ncbi.nlm.nih.gov/pubmed/26490740 https://doi.org/10.1538/expanim.15-0051 |
genre |
Acipenser baerii |
genre_facet |
Acipenser baerii |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783653/ http://www.ncbi.nlm.nih.gov/pubmed/26490740 http://dx.doi.org/10.1538/expanim.15-0051 |
op_rights |
©2016 Japanese Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
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CC-BY-NC-ND |
op_doi |
https://doi.org/10.1538/expanim.15-0051 |
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Experimental Animals |
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65 |
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77 |
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85 |
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