Missed, Not Missing: Phylogenomic Evidence for the Existence of Avian FoxP3

• Published in: PLOS ONE
• Main Authors: Denyer, Michael P., Pinheiro, Dammy Y., Garden, Oliver A., Shepherd, Adrian J.
• Format: Text
• Language: English
• Published: Public Library of Science 2016
• Subjects: Research Article; Parus; Falco peregrinus; peregrine falcon
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777427/; http://www.ncbi.nlm.nih.gov/pubmed/26938477; https://doi.org/10.1371/journal.pone.0150988

The Forkhead box transcription factor FoxP3 is pivotal to the development and function of regulatory T cells (Tregs), which make a major contribution to peripheral tolerance. FoxP3 is believed to perform a regulatory role in all the vertebrate species in which it has been detected. The prevailing vi...