Worldwide patterns of genomic variation and admixture in gray wolves
The gray wolf (Canis lupus) is a widely distributed top predator and ancestor of the domestic dog. To address questions about wolf relationships to each other and dogs, we assembled and analyzed a data set of 34 canine genomes. The divergence between New and Old World wolves is the earliest branchin...
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ftpubmed:oai:pubmedcentral.nih.gov:4728369 2023-05-15T15:50:31+02:00 Worldwide patterns of genomic variation and admixture in gray wolves Fan, Zhenxin Silva, Pedro Gronau, Ilan Wang, Shuoguo Armero, Aitor Serres Schweizer, Rena M. Ramirez, Oscar Pollinger, John Galaverni, Marco Ortega Del-Vecchyo, Diego Du, Lianming Zhang, Wenping Zhang, Zhihe Xing, Jinchuan Vilà, Carles Marques-Bonet, Tomas Godinho, Raquel Yue, Bisong Wayne, Robert K. 2016-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728369/ http://www.ncbi.nlm.nih.gov/pubmed/26680994 https://doi.org/10.1101/gr.197517.115 en eng Cold Spring Harbor Laboratory Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728369/ http://www.ncbi.nlm.nih.gov/pubmed/26680994 http://dx.doi.org/10.1101/gr.197517.115 © 2016 Fan et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. CC-BY-NC Research Text 2016 ftpubmed https://doi.org/10.1101/gr.197517.115 2016-08-07T00:12:46Z The gray wolf (Canis lupus) is a widely distributed top predator and ancestor of the domestic dog. To address questions about wolf relationships to each other and dogs, we assembled and analyzed a data set of 34 canine genomes. The divergence between New and Old World wolves is the earliest branching event and is followed by the divergence of Old World wolves and dogs, confirming that the dog was domesticated in the Old World. However, no single wolf population is more closely related to dogs, supporting the hypothesis that dogs were derived from an extinct wolf population. All extant wolves have a surprisingly recent common ancestry and experienced a dramatic population decline beginning at least ∼30 thousand years ago (kya). We suggest this crisis was related to the colonization of Eurasia by modern human hunter–gatherers, who competed with wolves for limited prey but also domesticated them, leading to a compensatory population expansion of dogs. We found extensive admixture between dogs and wolves, with up to 25% of Eurasian wolf genomes showing signs of dog ancestry. Dogs have influenced the recent history of wolves through admixture and vice versa, potentially enhancing adaptation. Simple scenarios of dog domestication are confounded by admixture, and studies that do not take admixture into account with specific demographic models are problematic. Text Canis lupus gray wolf PubMed Central (PMC) Kya ENVELOPE(8.308,8.308,63.772,63.772) Genome Research 26 2 163 173 |
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Research Fan, Zhenxin Silva, Pedro Gronau, Ilan Wang, Shuoguo Armero, Aitor Serres Schweizer, Rena M. Ramirez, Oscar Pollinger, John Galaverni, Marco Ortega Del-Vecchyo, Diego Du, Lianming Zhang, Wenping Zhang, Zhihe Xing, Jinchuan Vilà, Carles Marques-Bonet, Tomas Godinho, Raquel Yue, Bisong Wayne, Robert K. Worldwide patterns of genomic variation and admixture in gray wolves |
topic_facet |
Research |
description |
The gray wolf (Canis lupus) is a widely distributed top predator and ancestor of the domestic dog. To address questions about wolf relationships to each other and dogs, we assembled and analyzed a data set of 34 canine genomes. The divergence between New and Old World wolves is the earliest branching event and is followed by the divergence of Old World wolves and dogs, confirming that the dog was domesticated in the Old World. However, no single wolf population is more closely related to dogs, supporting the hypothesis that dogs were derived from an extinct wolf population. All extant wolves have a surprisingly recent common ancestry and experienced a dramatic population decline beginning at least ∼30 thousand years ago (kya). We suggest this crisis was related to the colonization of Eurasia by modern human hunter–gatherers, who competed with wolves for limited prey but also domesticated them, leading to a compensatory population expansion of dogs. We found extensive admixture between dogs and wolves, with up to 25% of Eurasian wolf genomes showing signs of dog ancestry. Dogs have influenced the recent history of wolves through admixture and vice versa, potentially enhancing adaptation. Simple scenarios of dog domestication are confounded by admixture, and studies that do not take admixture into account with specific demographic models are problematic. |
format |
Text |
author |
Fan, Zhenxin Silva, Pedro Gronau, Ilan Wang, Shuoguo Armero, Aitor Serres Schweizer, Rena M. Ramirez, Oscar Pollinger, John Galaverni, Marco Ortega Del-Vecchyo, Diego Du, Lianming Zhang, Wenping Zhang, Zhihe Xing, Jinchuan Vilà, Carles Marques-Bonet, Tomas Godinho, Raquel Yue, Bisong Wayne, Robert K. |
author_facet |
Fan, Zhenxin Silva, Pedro Gronau, Ilan Wang, Shuoguo Armero, Aitor Serres Schweizer, Rena M. Ramirez, Oscar Pollinger, John Galaverni, Marco Ortega Del-Vecchyo, Diego Du, Lianming Zhang, Wenping Zhang, Zhihe Xing, Jinchuan Vilà, Carles Marques-Bonet, Tomas Godinho, Raquel Yue, Bisong Wayne, Robert K. |
author_sort |
Fan, Zhenxin |
title |
Worldwide patterns of genomic variation and admixture in gray wolves |
title_short |
Worldwide patterns of genomic variation and admixture in gray wolves |
title_full |
Worldwide patterns of genomic variation and admixture in gray wolves |
title_fullStr |
Worldwide patterns of genomic variation and admixture in gray wolves |
title_full_unstemmed |
Worldwide patterns of genomic variation and admixture in gray wolves |
title_sort |
worldwide patterns of genomic variation and admixture in gray wolves |
publisher |
Cold Spring Harbor Laboratory Press |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728369/ http://www.ncbi.nlm.nih.gov/pubmed/26680994 https://doi.org/10.1101/gr.197517.115 |
long_lat |
ENVELOPE(8.308,8.308,63.772,63.772) |
geographic |
Kya |
geographic_facet |
Kya |
genre |
Canis lupus gray wolf |
genre_facet |
Canis lupus gray wolf |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728369/ http://www.ncbi.nlm.nih.gov/pubmed/26680994 http://dx.doi.org/10.1101/gr.197517.115 |
op_rights |
© 2016 Fan et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
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CC-BY-NC |
op_doi |
https://doi.org/10.1101/gr.197517.115 |
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Genome Research |
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26 |
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2 |
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163 |
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173 |
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1766385476488396800 |