Deep History of East Asian Populations Revealed Through Genetic Analysis of the Ainu
Despite recent advances in population genomics, much remains to be elucidated with regard to East Asian population history. The Ainu, a hunter–gatherer population of northern Japan and Sakhalin island of Russia, are thought to be key to elucidating the prehistory of Japan and the peopling of East As...
Published in: | Genetics |
---|---|
Main Authors: | , , |
Format: | Text |
Language: | English |
Published: |
Genetics Society of America
2016
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701090/ http://www.ncbi.nlm.nih.gov/pubmed/26500257 https://doi.org/10.1534/genetics.115.178673 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:4701090 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:4701090 2023-05-15T18:09:10+02:00 Deep History of East Asian Populations Revealed Through Genetic Analysis of the Ainu Jeong, Choongwon Nakagome, Shigeki Di Rienzo, Anna 2016-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701090/ http://www.ncbi.nlm.nih.gov/pubmed/26500257 https://doi.org/10.1534/genetics.115.178673 en eng Genetics Society of America http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701090/ http://www.ncbi.nlm.nih.gov/pubmed/26500257 http://dx.doi.org/10.1534/genetics.115.178673 Copyright © 2016 by the Genetics Society of America Investigations Text 2016 ftpubmed https://doi.org/10.1534/genetics.115.178673 2017-01-08T01:04:40Z Despite recent advances in population genomics, much remains to be elucidated with regard to East Asian population history. The Ainu, a hunter–gatherer population of northern Japan and Sakhalin island of Russia, are thought to be key to elucidating the prehistory of Japan and the peopling of East Asia. Here, we study the genetic relationship of the Ainu with other East Asian and Siberian populations outside the Japanese archipelago using genome-wide genotyping data. We find that the Ainu represent a deep branch of East Asian diversity more basal than all present-day East Asian farmers. However, we did not find a genetic connection between the Ainu and populations of the Tibetan plateau, rejecting their long-held hypothetical connection based on Y chromosome data. Unlike all other East Asian populations investigated, the Ainu have a closer genetic relationship with northeast Siberians than with central Siberians, suggesting ancient connections among populations around the Sea of Okhotsk. We also detect a recent genetic contribution of the Ainu to nearby populations, but no evidence for reciprocal recent gene flow is observed. Whole genome sequencing of contemporary and ancient Ainu individuals will be helpful to understand the details of the deep history of East Asians. Text Sakhalin PubMed Central (PMC) Okhotsk Genetics 202 1 261 272 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Investigations |
spellingShingle |
Investigations Jeong, Choongwon Nakagome, Shigeki Di Rienzo, Anna Deep History of East Asian Populations Revealed Through Genetic Analysis of the Ainu |
topic_facet |
Investigations |
description |
Despite recent advances in population genomics, much remains to be elucidated with regard to East Asian population history. The Ainu, a hunter–gatherer population of northern Japan and Sakhalin island of Russia, are thought to be key to elucidating the prehistory of Japan and the peopling of East Asia. Here, we study the genetic relationship of the Ainu with other East Asian and Siberian populations outside the Japanese archipelago using genome-wide genotyping data. We find that the Ainu represent a deep branch of East Asian diversity more basal than all present-day East Asian farmers. However, we did not find a genetic connection between the Ainu and populations of the Tibetan plateau, rejecting their long-held hypothetical connection based on Y chromosome data. Unlike all other East Asian populations investigated, the Ainu have a closer genetic relationship with northeast Siberians than with central Siberians, suggesting ancient connections among populations around the Sea of Okhotsk. We also detect a recent genetic contribution of the Ainu to nearby populations, but no evidence for reciprocal recent gene flow is observed. Whole genome sequencing of contemporary and ancient Ainu individuals will be helpful to understand the details of the deep history of East Asians. |
format |
Text |
author |
Jeong, Choongwon Nakagome, Shigeki Di Rienzo, Anna |
author_facet |
Jeong, Choongwon Nakagome, Shigeki Di Rienzo, Anna |
author_sort |
Jeong, Choongwon |
title |
Deep History of East Asian Populations Revealed Through Genetic Analysis of the Ainu |
title_short |
Deep History of East Asian Populations Revealed Through Genetic Analysis of the Ainu |
title_full |
Deep History of East Asian Populations Revealed Through Genetic Analysis of the Ainu |
title_fullStr |
Deep History of East Asian Populations Revealed Through Genetic Analysis of the Ainu |
title_full_unstemmed |
Deep History of East Asian Populations Revealed Through Genetic Analysis of the Ainu |
title_sort |
deep history of east asian populations revealed through genetic analysis of the ainu |
publisher |
Genetics Society of America |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701090/ http://www.ncbi.nlm.nih.gov/pubmed/26500257 https://doi.org/10.1534/genetics.115.178673 |
geographic |
Okhotsk |
geographic_facet |
Okhotsk |
genre |
Sakhalin |
genre_facet |
Sakhalin |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701090/ http://www.ncbi.nlm.nih.gov/pubmed/26500257 http://dx.doi.org/10.1534/genetics.115.178673 |
op_rights |
Copyright © 2016 by the Genetics Society of America |
op_doi |
https://doi.org/10.1534/genetics.115.178673 |
container_title |
Genetics |
container_volume |
202 |
container_issue |
1 |
container_start_page |
261 |
op_container_end_page |
272 |
_version_ |
1766181612456771584 |