A phylogenomic analysis of the role and timing of molecular adaptation in the aquatic transition of cetartiodactyl mammals
Recent studies have reported multiple cases of molecular adaptation in cetaceans related to their aquatic abilities. However, none of these has included the hippopotamus, precluding an understanding of whether molecular adaptations in cetaceans occurred before or after they split from their semi-aqu...
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ftpubmed:oai:pubmedcentral.nih.gov:4593674 2023-05-15T16:36:02+02:00 A phylogenomic analysis of the role and timing of molecular adaptation in the aquatic transition of cetartiodactyl mammals Tsagkogeorga, Georgia McGowen, Michael R. Davies, Kalina T. J. Jarman, Simon Polanowski, Andrea Bertelsen, Mads F. Rossiter, Stephen J. 2015-09-30 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593674/ https://doi.org/10.1098/rsos.150156 en eng The Royal Society Publishing http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593674/ http://dx.doi.org/10.1098/rsos.150156 http://creativecommons.org/licenses/by/4.0/ © 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. CC-BY Biology (Whole Organism) Text 2015 ftpubmed https://doi.org/10.1098/rsos.150156 2015-10-18T00:13:42Z Recent studies have reported multiple cases of molecular adaptation in cetaceans related to their aquatic abilities. However, none of these has included the hippopotamus, precluding an understanding of whether molecular adaptations in cetaceans occurred before or after they split from their semi-aquatic sister taxa. Here, we obtained new transcriptomes from the hippopotamus and humpback whale, and analysed these together with available data from eight other cetaceans. We identified more than 11 000 orthologous genes and compiled a genome-wide dataset of 6845 coding DNA sequences among 23 mammals, to our knowledge the largest phylogenomic dataset to date for cetaceans. We found positive selection in nine genes on the branch leading to the common ancestor of hippopotamus and whales, and 461 genes in cetaceans compared to 64 in hippopotamus. Functional annotation revealed adaptations in diverse processes, including lipid metabolism, hypoxia, muscle and brain function. By combining these findings with data on protein–protein interactions, we found evidence suggesting clustering among gene products relating to nervous and muscular systems in cetaceans. We found little support for shared ancestral adaptations in the two taxa; most molecular adaptations in extant cetaceans occurred after their split with hippopotamids. Text Humpback Whale PubMed Central (PMC) Royal Society Open Science 2 9 150156 |
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Biology (Whole Organism) |
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Biology (Whole Organism) Tsagkogeorga, Georgia McGowen, Michael R. Davies, Kalina T. J. Jarman, Simon Polanowski, Andrea Bertelsen, Mads F. Rossiter, Stephen J. A phylogenomic analysis of the role and timing of molecular adaptation in the aquatic transition of cetartiodactyl mammals |
topic_facet |
Biology (Whole Organism) |
description |
Recent studies have reported multiple cases of molecular adaptation in cetaceans related to their aquatic abilities. However, none of these has included the hippopotamus, precluding an understanding of whether molecular adaptations in cetaceans occurred before or after they split from their semi-aquatic sister taxa. Here, we obtained new transcriptomes from the hippopotamus and humpback whale, and analysed these together with available data from eight other cetaceans. We identified more than 11 000 orthologous genes and compiled a genome-wide dataset of 6845 coding DNA sequences among 23 mammals, to our knowledge the largest phylogenomic dataset to date for cetaceans. We found positive selection in nine genes on the branch leading to the common ancestor of hippopotamus and whales, and 461 genes in cetaceans compared to 64 in hippopotamus. Functional annotation revealed adaptations in diverse processes, including lipid metabolism, hypoxia, muscle and brain function. By combining these findings with data on protein–protein interactions, we found evidence suggesting clustering among gene products relating to nervous and muscular systems in cetaceans. We found little support for shared ancestral adaptations in the two taxa; most molecular adaptations in extant cetaceans occurred after their split with hippopotamids. |
format |
Text |
author |
Tsagkogeorga, Georgia McGowen, Michael R. Davies, Kalina T. J. Jarman, Simon Polanowski, Andrea Bertelsen, Mads F. Rossiter, Stephen J. |
author_facet |
Tsagkogeorga, Georgia McGowen, Michael R. Davies, Kalina T. J. Jarman, Simon Polanowski, Andrea Bertelsen, Mads F. Rossiter, Stephen J. |
author_sort |
Tsagkogeorga, Georgia |
title |
A phylogenomic analysis of the role and timing of molecular adaptation in the aquatic transition of cetartiodactyl mammals |
title_short |
A phylogenomic analysis of the role and timing of molecular adaptation in the aquatic transition of cetartiodactyl mammals |
title_full |
A phylogenomic analysis of the role and timing of molecular adaptation in the aquatic transition of cetartiodactyl mammals |
title_fullStr |
A phylogenomic analysis of the role and timing of molecular adaptation in the aquatic transition of cetartiodactyl mammals |
title_full_unstemmed |
A phylogenomic analysis of the role and timing of molecular adaptation in the aquatic transition of cetartiodactyl mammals |
title_sort |
phylogenomic analysis of the role and timing of molecular adaptation in the aquatic transition of cetartiodactyl mammals |
publisher |
The Royal Society Publishing |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593674/ https://doi.org/10.1098/rsos.150156 |
genre |
Humpback Whale |
genre_facet |
Humpback Whale |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593674/ http://dx.doi.org/10.1098/rsos.150156 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ © 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1098/rsos.150156 |
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Royal Society Open Science |
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2 |
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9 |
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150156 |
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1766026347299209216 |