Very low embryonic crude oil exposures cause lasting cardiac defects in salmon and herring
The 1989 Exxon Valdez disaster exposed embryos of pink salmon and Pacific herring to crude oil in shoreline spawning habitats throughout Prince William Sound, Alaska. The herring fishery collapsed four years later. The role of the spill, if any, in this decline remains one of the most controversial...
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ftpubmed:oai:pubmedcentral.nih.gov:4561892 2023-05-15T17:59:37+02:00 Very low embryonic crude oil exposures cause lasting cardiac defects in salmon and herring Incardona, John P. Carls, Mark G. Holland, Larry Linbo, Tiffany L. Baldwin, David H. Myers, Mark S. Peck, Karen A. Tagal, Mark Rice, Stanley D. Scholz, Nathaniel L. 2015-09-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561892/ http://www.ncbi.nlm.nih.gov/pubmed/26345607 https://doi.org/10.1038/srep13499 en eng Nature Publishing Group http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561892/ http://www.ncbi.nlm.nih.gov/pubmed/26345607 http://dx.doi.org/10.1038/srep13499 Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ CC-BY Article Text 2015 ftpubmed https://doi.org/10.1038/srep13499 2015-09-20T00:11:12Z The 1989 Exxon Valdez disaster exposed embryos of pink salmon and Pacific herring to crude oil in shoreline spawning habitats throughout Prince William Sound, Alaska. The herring fishery collapsed four years later. The role of the spill, if any, in this decline remains one of the most controversial unanswered questions in modern natural resource injury assessment. Crude oil disrupts excitation-contraction coupling in fish heart muscle cells, and we show here that salmon and herring exposed as embryos to trace levels of crude oil grow into juveniles with abnormal hearts and reduced cardiorespiratory function, the latter a key determinant of individual survival and population recruitment. Oil exposure during cardiogenesis led to specific defects in the outflow tract and compact myocardium, and a hypertrophic response in spongy myocardium, evident in juveniles 7 to 9 months after exposure. The thresholds for developmental cardiotoxicity were remarkably low, suggesting the scale of the Exxon Valdez impact in shoreline spawning habitats was much greater than previously appreciated. Moreover, an irreversible loss of cardiac fitness and consequent increases in delayed mortality in oil-exposed cohorts may have been important contributors to the delayed decline of pink salmon and herring stocks in Prince William Sound. Text Pink salmon Alaska PubMed Central (PMC) Pacific Scientific Reports 5 1 |
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Article Incardona, John P. Carls, Mark G. Holland, Larry Linbo, Tiffany L. Baldwin, David H. Myers, Mark S. Peck, Karen A. Tagal, Mark Rice, Stanley D. Scholz, Nathaniel L. Very low embryonic crude oil exposures cause lasting cardiac defects in salmon and herring |
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The 1989 Exxon Valdez disaster exposed embryos of pink salmon and Pacific herring to crude oil in shoreline spawning habitats throughout Prince William Sound, Alaska. The herring fishery collapsed four years later. The role of the spill, if any, in this decline remains one of the most controversial unanswered questions in modern natural resource injury assessment. Crude oil disrupts excitation-contraction coupling in fish heart muscle cells, and we show here that salmon and herring exposed as embryos to trace levels of crude oil grow into juveniles with abnormal hearts and reduced cardiorespiratory function, the latter a key determinant of individual survival and population recruitment. Oil exposure during cardiogenesis led to specific defects in the outflow tract and compact myocardium, and a hypertrophic response in spongy myocardium, evident in juveniles 7 to 9 months after exposure. The thresholds for developmental cardiotoxicity were remarkably low, suggesting the scale of the Exxon Valdez impact in shoreline spawning habitats was much greater than previously appreciated. Moreover, an irreversible loss of cardiac fitness and consequent increases in delayed mortality in oil-exposed cohorts may have been important contributors to the delayed decline of pink salmon and herring stocks in Prince William Sound. |
format |
Text |
author |
Incardona, John P. Carls, Mark G. Holland, Larry Linbo, Tiffany L. Baldwin, David H. Myers, Mark S. Peck, Karen A. Tagal, Mark Rice, Stanley D. Scholz, Nathaniel L. |
author_facet |
Incardona, John P. Carls, Mark G. Holland, Larry Linbo, Tiffany L. Baldwin, David H. Myers, Mark S. Peck, Karen A. Tagal, Mark Rice, Stanley D. Scholz, Nathaniel L. |
author_sort |
Incardona, John P. |
title |
Very low embryonic crude oil exposures cause lasting cardiac defects in salmon and herring |
title_short |
Very low embryonic crude oil exposures cause lasting cardiac defects in salmon and herring |
title_full |
Very low embryonic crude oil exposures cause lasting cardiac defects in salmon and herring |
title_fullStr |
Very low embryonic crude oil exposures cause lasting cardiac defects in salmon and herring |
title_full_unstemmed |
Very low embryonic crude oil exposures cause lasting cardiac defects in salmon and herring |
title_sort |
very low embryonic crude oil exposures cause lasting cardiac defects in salmon and herring |
publisher |
Nature Publishing Group |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561892/ http://www.ncbi.nlm.nih.gov/pubmed/26345607 https://doi.org/10.1038/srep13499 |
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Pacific |
geographic_facet |
Pacific |
genre |
Pink salmon Alaska |
genre_facet |
Pink salmon Alaska |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561892/ http://www.ncbi.nlm.nih.gov/pubmed/26345607 http://dx.doi.org/10.1038/srep13499 |
op_rights |
Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
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CC-BY |
op_doi |
https://doi.org/10.1038/srep13499 |
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Scientific Reports |
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5 |
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