Antarctic archaea–virus interactions: metaproteome-led analysis of invasion, evasion and adaptation
Despite knowledge that viruses are abundant in natural ecosystems, there is limited understanding of which viruses infect which hosts, and how both hosts and viruses respond to those interactions—interactions that ultimately shape community structure and dynamics. In Deep Lake, Antarctica, intergene...
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ftpubmed:oai:pubmedcentral.nih.gov:4542027 2023-05-15T13:53:13+02:00 Antarctic archaea–virus interactions: metaproteome-led analysis of invasion, evasion and adaptation Tschitschko, Bernhard Williams, Timothy J Allen, Michelle A Páez-Espino, David Kyrpides, Nikos Zhong, Ling Raftery, Mark J Cavicchioli, Ricardo 2015-09 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542027/ http://www.ncbi.nlm.nih.gov/pubmed/26125682 https://doi.org/10.1038/ismej.2015.110 en eng Nature Publishing Group http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542027/ http://www.ncbi.nlm.nih.gov/pubmed/26125682 http://dx.doi.org/10.1038/ismej.2015.110 Copyright © 2015 International Society for Microbial Ecology Original Article Text 2015 ftpubmed https://doi.org/10.1038/ismej.2015.110 2016-09-04T00:04:49Z Despite knowledge that viruses are abundant in natural ecosystems, there is limited understanding of which viruses infect which hosts, and how both hosts and viruses respond to those interactions—interactions that ultimately shape community structure and dynamics. In Deep Lake, Antarctica, intergenera gene exchange occurs rampantly within the low complexity, haloarchaea-dominated community, strongly balanced by distinctions in niche adaptation which maintain sympatric speciation. By performing metaproteomics for the first time on haloarchaea, genomic variation of S-layer, archaella and other cell surface proteins was linked to mechanisms of infection evasion. CRISPR defense systems were found to be active, with haloarchaea responding to at least eight distinct types of viruses, including those infecting between genera. The role of BREX systems in defending against viruses was also examined. Although evasion and defense were evident, both hosts and viruses also may benefit from viruses carrying and expressing host genes, thereby potentially enhancing genetic variation and phenotypic differences within populations. The data point to a complex inter-play leading to a dynamic optimization of host–virus interactions. This comprehensive overview was achieved only through the integration of results from metaproteomics, genomics and metagenomics. Text Antarc* Antarctic Antarctica PubMed Central (PMC) Antarctic The ISME Journal 9 9 2094 2107 |
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Original Article Tschitschko, Bernhard Williams, Timothy J Allen, Michelle A Páez-Espino, David Kyrpides, Nikos Zhong, Ling Raftery, Mark J Cavicchioli, Ricardo Antarctic archaea–virus interactions: metaproteome-led analysis of invasion, evasion and adaptation |
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Original Article |
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Despite knowledge that viruses are abundant in natural ecosystems, there is limited understanding of which viruses infect which hosts, and how both hosts and viruses respond to those interactions—interactions that ultimately shape community structure and dynamics. In Deep Lake, Antarctica, intergenera gene exchange occurs rampantly within the low complexity, haloarchaea-dominated community, strongly balanced by distinctions in niche adaptation which maintain sympatric speciation. By performing metaproteomics for the first time on haloarchaea, genomic variation of S-layer, archaella and other cell surface proteins was linked to mechanisms of infection evasion. CRISPR defense systems were found to be active, with haloarchaea responding to at least eight distinct types of viruses, including those infecting between genera. The role of BREX systems in defending against viruses was also examined. Although evasion and defense were evident, both hosts and viruses also may benefit from viruses carrying and expressing host genes, thereby potentially enhancing genetic variation and phenotypic differences within populations. The data point to a complex inter-play leading to a dynamic optimization of host–virus interactions. This comprehensive overview was achieved only through the integration of results from metaproteomics, genomics and metagenomics. |
format |
Text |
author |
Tschitschko, Bernhard Williams, Timothy J Allen, Michelle A Páez-Espino, David Kyrpides, Nikos Zhong, Ling Raftery, Mark J Cavicchioli, Ricardo |
author_facet |
Tschitschko, Bernhard Williams, Timothy J Allen, Michelle A Páez-Espino, David Kyrpides, Nikos Zhong, Ling Raftery, Mark J Cavicchioli, Ricardo |
author_sort |
Tschitschko, Bernhard |
title |
Antarctic archaea–virus interactions: metaproteome-led analysis of invasion, evasion and adaptation |
title_short |
Antarctic archaea–virus interactions: metaproteome-led analysis of invasion, evasion and adaptation |
title_full |
Antarctic archaea–virus interactions: metaproteome-led analysis of invasion, evasion and adaptation |
title_fullStr |
Antarctic archaea–virus interactions: metaproteome-led analysis of invasion, evasion and adaptation |
title_full_unstemmed |
Antarctic archaea–virus interactions: metaproteome-led analysis of invasion, evasion and adaptation |
title_sort |
antarctic archaea–virus interactions: metaproteome-led analysis of invasion, evasion and adaptation |
publisher |
Nature Publishing Group |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542027/ http://www.ncbi.nlm.nih.gov/pubmed/26125682 https://doi.org/10.1038/ismej.2015.110 |
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Antarctic |
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Antarctic |
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Antarc* Antarctic Antarctica |
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Antarc* Antarctic Antarctica |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542027/ http://www.ncbi.nlm.nih.gov/pubmed/26125682 http://dx.doi.org/10.1038/ismej.2015.110 |
op_rights |
Copyright © 2015 International Society for Microbial Ecology |
op_doi |
https://doi.org/10.1038/ismej.2015.110 |
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The ISME Journal |
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9 |
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9 |
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2094 |
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2107 |
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1766258193984389120 |