Effects of Omega-3-Rich Harp Seal Oil on the Production of Pro-Inflammatory Cytokines in Mouse Peritoneal Macrophages
Omega-3, a polyunsaturated fatty acid, is an essential fatty acid necessary for human health, and it protects against cardiovascular disease, inflammation, autoimmune diseases, and cancer. In the present study, we investigated the effects of omega-3-rich harp seal oil (HSO) on the production of nitr...
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ftpubmed:oai:pubmedcentral.nih.gov:4500520 2023-05-15T16:33:43+02:00 Effects of Omega-3-Rich Harp Seal Oil on the Production of Pro-Inflammatory Cytokines in Mouse Peritoneal Macrophages Choi, Myungwon Ju, Jaehyun Suh, Jae Soo Park, Kun-Young Kim, Kwang Hyuk 2015-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500520/ http://www.ncbi.nlm.nih.gov/pubmed/26175994 https://doi.org/10.3746/pnf.2015.20.2.83 en eng The Korean Society of Food Science and Nutrition http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500520/ http://www.ncbi.nlm.nih.gov/pubmed/26175994 http://dx.doi.org/10.3746/pnf.2015.20.2.83 Copyright © 2015 by The Korean Society of Food Science and Nutrition. All rights Reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY-NC Articles Text 2015 ftpubmed https://doi.org/10.3746/pnf.2015.20.2.83 2015-07-19T01:05:18Z Omega-3, a polyunsaturated fatty acid, is an essential fatty acid necessary for human health, and it protects against cardiovascular disease, inflammation, autoimmune diseases, and cancer. In the present study, we investigated the effects of omega-3-rich harp seal oil (HSO) on the production of nitric oxide (NO) and cytokines, such as tumor necrosis factor (TNF)-α, interleukin-(IL)-1β, IL-6, and IL-12/IL-23 (p40) in peritoneal macrophages of mice. The culture supernatants of murine macrophages exposed to lipopolysaccharide (LPS), HSO, or HSO+LPS were harvested to assay IL-1β, TNF-α, IL-6, and IL-12/IL-23 (p40) cytokines and NO. TNF-α, IL-1 β, and IL-12/IL-23 (p40) levels, except IL-6, were lower in the culture supernatants of mouse peritoneal macrophages exposed to LPS plus HSO than those of the groups exposed to LPS alone. These observations demonstrate that omega-3-rich harp seal oil downregulates the production of the pro-inflammatory cytokines such as IL-1β, TNF-α, and IL-12/IL-23 (p40). These results suggest that HSO could be potentially used as a preventive agent or as an adjunct in anti-inflammatory therapy, if more research results were accumulated. Text Harp Seal PubMed Central (PMC) Preventive Nutrition and Food Science 20 2 83 87 |
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Articles Choi, Myungwon Ju, Jaehyun Suh, Jae Soo Park, Kun-Young Kim, Kwang Hyuk Effects of Omega-3-Rich Harp Seal Oil on the Production of Pro-Inflammatory Cytokines in Mouse Peritoneal Macrophages |
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Articles |
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Omega-3, a polyunsaturated fatty acid, is an essential fatty acid necessary for human health, and it protects against cardiovascular disease, inflammation, autoimmune diseases, and cancer. In the present study, we investigated the effects of omega-3-rich harp seal oil (HSO) on the production of nitric oxide (NO) and cytokines, such as tumor necrosis factor (TNF)-α, interleukin-(IL)-1β, IL-6, and IL-12/IL-23 (p40) in peritoneal macrophages of mice. The culture supernatants of murine macrophages exposed to lipopolysaccharide (LPS), HSO, or HSO+LPS were harvested to assay IL-1β, TNF-α, IL-6, and IL-12/IL-23 (p40) cytokines and NO. TNF-α, IL-1 β, and IL-12/IL-23 (p40) levels, except IL-6, were lower in the culture supernatants of mouse peritoneal macrophages exposed to LPS plus HSO than those of the groups exposed to LPS alone. These observations demonstrate that omega-3-rich harp seal oil downregulates the production of the pro-inflammatory cytokines such as IL-1β, TNF-α, and IL-12/IL-23 (p40). These results suggest that HSO could be potentially used as a preventive agent or as an adjunct in anti-inflammatory therapy, if more research results were accumulated. |
format |
Text |
author |
Choi, Myungwon Ju, Jaehyun Suh, Jae Soo Park, Kun-Young Kim, Kwang Hyuk |
author_facet |
Choi, Myungwon Ju, Jaehyun Suh, Jae Soo Park, Kun-Young Kim, Kwang Hyuk |
author_sort |
Choi, Myungwon |
title |
Effects of Omega-3-Rich Harp Seal Oil on the Production of Pro-Inflammatory Cytokines in Mouse Peritoneal Macrophages |
title_short |
Effects of Omega-3-Rich Harp Seal Oil on the Production of Pro-Inflammatory Cytokines in Mouse Peritoneal Macrophages |
title_full |
Effects of Omega-3-Rich Harp Seal Oil on the Production of Pro-Inflammatory Cytokines in Mouse Peritoneal Macrophages |
title_fullStr |
Effects of Omega-3-Rich Harp Seal Oil on the Production of Pro-Inflammatory Cytokines in Mouse Peritoneal Macrophages |
title_full_unstemmed |
Effects of Omega-3-Rich Harp Seal Oil on the Production of Pro-Inflammatory Cytokines in Mouse Peritoneal Macrophages |
title_sort |
effects of omega-3-rich harp seal oil on the production of pro-inflammatory cytokines in mouse peritoneal macrophages |
publisher |
The Korean Society of Food Science and Nutrition |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500520/ http://www.ncbi.nlm.nih.gov/pubmed/26175994 https://doi.org/10.3746/pnf.2015.20.2.83 |
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Harp Seal |
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Harp Seal |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500520/ http://www.ncbi.nlm.nih.gov/pubmed/26175994 http://dx.doi.org/10.3746/pnf.2015.20.2.83 |
op_rights |
Copyright © 2015 by The Korean Society of Food Science and Nutrition. All rights Reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.3746/pnf.2015.20.2.83 |
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Preventive Nutrition and Food Science |
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20 |
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2 |
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83 |
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87 |
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