Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015
Timely and accurate measurement of population protection against measles is critical for decision-making and prevention of outbreaks. However, little is known about how survey-based estimates of immunization (crude coverage) compare to the seroprevalence of antibodies (effective coverage), particula...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489764/ http://www.ncbi.nlm.nih.gov/pubmed/26136239 https://doi.org/10.1371/journal.pone.0130697 |
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ftpubmed:oai:pubmedcentral.nih.gov:4489764 2023-05-15T17:36:21+02:00 Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015 Colson, K. Ellicott Zúñiga-Brenes, Paola Ríos-Zertuche, Diego Conde-Glez, Carlos J. Gagnier, Marielle C. Palmisano, Erin Ranganathan, Dharani Usmanova, Gulnoza Salvatierra, Benito Nazar, Austreberta Tristao, Ignez Sanchez Monin, Emmanuelle Anderson, Brent W. Haakenstad, Annie Murphy, Tasha Lim, Stephen Hernandez, Bernardo Lozano, Rafael Iriarte, Emma Mokdad, Ali H. 2015-07-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489764/ http://www.ncbi.nlm.nih.gov/pubmed/26136239 https://doi.org/10.1371/journal.pone.0130697 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489764/ http://www.ncbi.nlm.nih.gov/pubmed/26136239 http://dx.doi.org/10.1371/journal.pone.0130697 http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited CC-BY Research Article Text 2015 ftpubmed https://doi.org/10.1371/journal.pone.0130697 2015-07-19T00:58:31Z Timely and accurate measurement of population protection against measles is critical for decision-making and prevention of outbreaks. However, little is known about how survey-based estimates of immunization (crude coverage) compare to the seroprevalence of antibodies (effective coverage), particularly in low-resource settings. In poor areas of Mexico and Nicaragua, we used household surveys to gather information on measles immunization from child health cards and caregiver recall. We also collected dried blood spots (DBS) from children aged 12 to 23 months to compare crude and effective coverage of measles immunization. We used survey-weighted logistic regression to identify individual, maternal, household, community, and health facility characteristics that predict gaps between crude coverage and effective coverage. We found that crude coverage was significantly higher than effective coverage (83% versus 68% in Mexico; 85% versus 50% in Nicaragua). A large proportion of children (19% in Mexico; 43% in Nicaragua) had health card documentation of measles immunization but lacked antibodies. These discrepancies varied from 0% to 100% across municipalities in each country. In multivariate analyses, card-positive children in Mexico were more likely to lack antibodies if they resided in urban areas or the jurisdiction of De Los Llanos. In contrast, card-positive children in Nicaragua were more likely to lack antibodies if they resided in rural areas or the North Atlantic region, had low weight-for-age, or attended health facilities with a greater number of refrigerators. Findings highlight that reliance on child health cards to measure population protection against measles is unwise. We call for the evaluation of immunization programs using serological methods, especially in poor areas where the cold chain is likely to be compromised. Identification of within-country variation in effective coverage of measles immunization will allow researchers and public health professionals to address challenges in current ... Text North Atlantic PubMed Central (PMC) PLOS ONE 10 7 e0130697 |
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Research Article Colson, K. Ellicott Zúñiga-Brenes, Paola Ríos-Zertuche, Diego Conde-Glez, Carlos J. Gagnier, Marielle C. Palmisano, Erin Ranganathan, Dharani Usmanova, Gulnoza Salvatierra, Benito Nazar, Austreberta Tristao, Ignez Sanchez Monin, Emmanuelle Anderson, Brent W. Haakenstad, Annie Murphy, Tasha Lim, Stephen Hernandez, Bernardo Lozano, Rafael Iriarte, Emma Mokdad, Ali H. Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015 |
topic_facet |
Research Article |
description |
Timely and accurate measurement of population protection against measles is critical for decision-making and prevention of outbreaks. However, little is known about how survey-based estimates of immunization (crude coverage) compare to the seroprevalence of antibodies (effective coverage), particularly in low-resource settings. In poor areas of Mexico and Nicaragua, we used household surveys to gather information on measles immunization from child health cards and caregiver recall. We also collected dried blood spots (DBS) from children aged 12 to 23 months to compare crude and effective coverage of measles immunization. We used survey-weighted logistic regression to identify individual, maternal, household, community, and health facility characteristics that predict gaps between crude coverage and effective coverage. We found that crude coverage was significantly higher than effective coverage (83% versus 68% in Mexico; 85% versus 50% in Nicaragua). A large proportion of children (19% in Mexico; 43% in Nicaragua) had health card documentation of measles immunization but lacked antibodies. These discrepancies varied from 0% to 100% across municipalities in each country. In multivariate analyses, card-positive children in Mexico were more likely to lack antibodies if they resided in urban areas or the jurisdiction of De Los Llanos. In contrast, card-positive children in Nicaragua were more likely to lack antibodies if they resided in rural areas or the North Atlantic region, had low weight-for-age, or attended health facilities with a greater number of refrigerators. Findings highlight that reliance on child health cards to measure population protection against measles is unwise. We call for the evaluation of immunization programs using serological methods, especially in poor areas where the cold chain is likely to be compromised. Identification of within-country variation in effective coverage of measles immunization will allow researchers and public health professionals to address challenges in current ... |
format |
Text |
author |
Colson, K. Ellicott Zúñiga-Brenes, Paola Ríos-Zertuche, Diego Conde-Glez, Carlos J. Gagnier, Marielle C. Palmisano, Erin Ranganathan, Dharani Usmanova, Gulnoza Salvatierra, Benito Nazar, Austreberta Tristao, Ignez Sanchez Monin, Emmanuelle Anderson, Brent W. Haakenstad, Annie Murphy, Tasha Lim, Stephen Hernandez, Bernardo Lozano, Rafael Iriarte, Emma Mokdad, Ali H. |
author_facet |
Colson, K. Ellicott Zúñiga-Brenes, Paola Ríos-Zertuche, Diego Conde-Glez, Carlos J. Gagnier, Marielle C. Palmisano, Erin Ranganathan, Dharani Usmanova, Gulnoza Salvatierra, Benito Nazar, Austreberta Tristao, Ignez Sanchez Monin, Emmanuelle Anderson, Brent W. Haakenstad, Annie Murphy, Tasha Lim, Stephen Hernandez, Bernardo Lozano, Rafael Iriarte, Emma Mokdad, Ali H. |
author_sort |
Colson, K. Ellicott |
title |
Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015 |
title_short |
Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015 |
title_full |
Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015 |
title_fullStr |
Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015 |
title_full_unstemmed |
Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015 |
title_sort |
comparative estimates of crude and effective coverage of measles immunization in low-resource settings: findings from salud mesoamérica 2015 |
publisher |
Public Library of Science |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489764/ http://www.ncbi.nlm.nih.gov/pubmed/26136239 https://doi.org/10.1371/journal.pone.0130697 |
genre |
North Atlantic |
genre_facet |
North Atlantic |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489764/ http://www.ncbi.nlm.nih.gov/pubmed/26136239 http://dx.doi.org/10.1371/journal.pone.0130697 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0130697 |
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PLOS ONE |
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10 |
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7 |
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e0130697 |
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