Echinococcosis: An Economic Evaluation of a Veterinary Public Health Intervention in Rural Canada
Echinococcosis is a rare but endemic condition in people in Canada, caused by a zoonotic cestode for which the source of human infection is ingestion of parasite eggs shed by canids. The objectives of this study were to identify risk factors associated with infection and to measure the cost-utility...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , |
Format: | Text |
Language: | English |
Published: |
Public Library of Science
2015
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489623/ http://www.ncbi.nlm.nih.gov/pubmed/26135476 https://doi.org/10.1371/journal.pntd.0003883 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:4489623 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:4489623 2023-05-15T17:46:45+02:00 Echinococcosis: An Economic Evaluation of a Veterinary Public Health Intervention in Rural Canada Schurer, Janna M. Rafferty, Ellen Farag, Marwa Zeng, Wu Jenkins, Emily J. 2015-07-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489623/ http://www.ncbi.nlm.nih.gov/pubmed/26135476 https://doi.org/10.1371/journal.pntd.0003883 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489623/ http://www.ncbi.nlm.nih.gov/pubmed/26135476 http://dx.doi.org/10.1371/journal.pntd.0003883 http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited CC-BY Research Article Text 2015 ftpubmed https://doi.org/10.1371/journal.pntd.0003883 2015-07-19T00:58:22Z Echinococcosis is a rare but endemic condition in people in Canada, caused by a zoonotic cestode for which the source of human infection is ingestion of parasite eggs shed by canids. The objectives of this study were to identify risk factors associated with infection and to measure the cost-utility of introducing an echinococcosis prevention program in a rural area. We analyzed human case reports submitted to the Canadian Institutes for Health Information between 2002 and 2011. Over this 10 year period, there were 48 cases associated with E. granulosus/E. canadensis, 16 with E. multilocularis, and 251 cases of echinococcosis for which species was not identified (total 315 cases). Nationally, annual incidence of echinococcosis was 0.14 cases per 100 000 people, which is likely an underestimate due to under-diagnosis and under-reporting. Risk factors for echinococcosis included female gender, age (>65 years), and residing in one of the northern territories (Nunavut, Yukon, or Northwest Territories). The average cost of treating a case of cystic echinococcosis in Canada was $8,842 CAD. Cost-utility analysis revealed that dosing dogs with praziquantel (a cestocide) at six week intervals to control cystic echinococcosis is not currently cost-effective at a threshold of $20,000-100,000 per Quality Adjusted Life Year (QALY) gained, even in a health region with the highest incidence rate in Canada ($666,978 -755,051 per QALY gained). However, threshold analysis demonstrated that the program may become cost-saving at an echinococcosis incidence of 13-85 cases per 100,000 people and therefore, even one additional CE case in a community of 9000 people could result in the monetary benefits of the program outweighing costs. Text Northwest Territories Nunavut Yukon PubMed Central (PMC) Canada Northwest Territories Nunavut Yukon PLOS Neglected Tropical Diseases 9 7 e0003883 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Research Article |
spellingShingle |
Research Article Schurer, Janna M. Rafferty, Ellen Farag, Marwa Zeng, Wu Jenkins, Emily J. Echinococcosis: An Economic Evaluation of a Veterinary Public Health Intervention in Rural Canada |
topic_facet |
Research Article |
description |
Echinococcosis is a rare but endemic condition in people in Canada, caused by a zoonotic cestode for which the source of human infection is ingestion of parasite eggs shed by canids. The objectives of this study were to identify risk factors associated with infection and to measure the cost-utility of introducing an echinococcosis prevention program in a rural area. We analyzed human case reports submitted to the Canadian Institutes for Health Information between 2002 and 2011. Over this 10 year period, there were 48 cases associated with E. granulosus/E. canadensis, 16 with E. multilocularis, and 251 cases of echinococcosis for which species was not identified (total 315 cases). Nationally, annual incidence of echinococcosis was 0.14 cases per 100 000 people, which is likely an underestimate due to under-diagnosis and under-reporting. Risk factors for echinococcosis included female gender, age (>65 years), and residing in one of the northern territories (Nunavut, Yukon, or Northwest Territories). The average cost of treating a case of cystic echinococcosis in Canada was $8,842 CAD. Cost-utility analysis revealed that dosing dogs with praziquantel (a cestocide) at six week intervals to control cystic echinococcosis is not currently cost-effective at a threshold of $20,000-100,000 per Quality Adjusted Life Year (QALY) gained, even in a health region with the highest incidence rate in Canada ($666,978 -755,051 per QALY gained). However, threshold analysis demonstrated that the program may become cost-saving at an echinococcosis incidence of 13-85 cases per 100,000 people and therefore, even one additional CE case in a community of 9000 people could result in the monetary benefits of the program outweighing costs. |
format |
Text |
author |
Schurer, Janna M. Rafferty, Ellen Farag, Marwa Zeng, Wu Jenkins, Emily J. |
author_facet |
Schurer, Janna M. Rafferty, Ellen Farag, Marwa Zeng, Wu Jenkins, Emily J. |
author_sort |
Schurer, Janna M. |
title |
Echinococcosis: An Economic Evaluation of a Veterinary Public Health Intervention in Rural Canada |
title_short |
Echinococcosis: An Economic Evaluation of a Veterinary Public Health Intervention in Rural Canada |
title_full |
Echinococcosis: An Economic Evaluation of a Veterinary Public Health Intervention in Rural Canada |
title_fullStr |
Echinococcosis: An Economic Evaluation of a Veterinary Public Health Intervention in Rural Canada |
title_full_unstemmed |
Echinococcosis: An Economic Evaluation of a Veterinary Public Health Intervention in Rural Canada |
title_sort |
echinococcosis: an economic evaluation of a veterinary public health intervention in rural canada |
publisher |
Public Library of Science |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489623/ http://www.ncbi.nlm.nih.gov/pubmed/26135476 https://doi.org/10.1371/journal.pntd.0003883 |
geographic |
Canada Northwest Territories Nunavut Yukon |
geographic_facet |
Canada Northwest Territories Nunavut Yukon |
genre |
Northwest Territories Nunavut Yukon |
genre_facet |
Northwest Territories Nunavut Yukon |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489623/ http://www.ncbi.nlm.nih.gov/pubmed/26135476 http://dx.doi.org/10.1371/journal.pntd.0003883 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pntd.0003883 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
9 |
container_issue |
7 |
container_start_page |
e0003883 |
_version_ |
1766150589237952512 |