A Single Dose of an Avian H3N8 Influenza Virus Vaccine Is Highly Immunogenic and Efficacious against a Recently Emerged Seal Influenza Virus in Mice and Ferrets
H3N8 influenza viruses are a commonly found subtype in wild birds, usually causing mild or no disease in infected birds. However, they have crossed the species barrier and have been associated with outbreaks in dogs, pigs, donkeys, and seals and therefore pose a threat to humans. A live attenuated,...
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ftpubmed:oai:pubmedcentral.nih.gov:4468475 2023-05-15T16:33:10+02:00 A Single Dose of an Avian H3N8 Influenza Virus Vaccine Is Highly Immunogenic and Efficacious against a Recently Emerged Seal Influenza Virus in Mice and Ferrets Baz, Mariana Paskel, Myeisha Matsuoka, Yumiko Zengel, James R. Cheng, Xing Treanor, John J. Jin, Hong Subbarao, Kanta 2015-04-22 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468475/ http://www.ncbi.nlm.nih.gov/pubmed/25903333 https://doi.org/10.1128/JVI.00280-15 en eng American Society for Microbiology http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468475/ http://www.ncbi.nlm.nih.gov/pubmed/25903333 http://dx.doi.org/10.1128/JVI.00280-15 Copyright © 2015, American Society for Microbiology. All Rights Reserved. Vaccines and Antiviral Agents Text 2015 ftpubmed https://doi.org/10.1128/JVI.00280-15 2016-01-03T01:23:18Z H3N8 influenza viruses are a commonly found subtype in wild birds, usually causing mild or no disease in infected birds. However, they have crossed the species barrier and have been associated with outbreaks in dogs, pigs, donkeys, and seals and therefore pose a threat to humans. A live attenuated, cold-adapted (ca) H3N8 vaccine virus was generated by reverse genetics using the wild-type (wt) hemagglutinin (HA) and neuraminidase (NA) genes from the A/blue-winged teal/Texas/Sg-00079/2007 (H3N8) (tl/TX/079/07) wt virus and the six internal protein gene segments from the ca influenza A virus vaccine donor strain, A/Ann Arbor/6/60 ca (H2N2), the backbone of the licensed seasonal live attenuated influenza vaccine. One dose of the tl/TX/079/07 ca vaccine induced a robust neutralizing antibody response against the homologous (tl/TX/079/07) and two heterologous influenza viruses, including the recently emerged A/harbor seal/New Hampshire/179629/2011 (H3N8) and A/northern pintail/Alaska/44228-129/2006 (H3N8) viruses, and conferred robust protection against the homologous and heterologous influenza viruses. We also analyzed human sera against the tl/TX/079/07 H3N8 avian influenza virus and observed low but detectable antibody reactivity in elderly subjects, suggesting that older H3N2 influenza viruses confer some cross-reactive antibody. The latter observation was confirmed in a ferret study. The safety, immunogenicity, and efficacy of the tl/TX/079/07 ca vaccine in mice and ferrets support further evaluation of this vaccine in humans for use in the event of transmission of an H3N8 avian influenza virus to humans. The human and ferret serology data suggest that a single dose of the vaccine may be sufficient in older subjects. Text harbor seal Alaska PubMed Central (PMC) Journal of Virology 89 13 6907 6917 |
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English |
topic |
Vaccines and Antiviral Agents |
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Vaccines and Antiviral Agents Baz, Mariana Paskel, Myeisha Matsuoka, Yumiko Zengel, James R. Cheng, Xing Treanor, John J. Jin, Hong Subbarao, Kanta A Single Dose of an Avian H3N8 Influenza Virus Vaccine Is Highly Immunogenic and Efficacious against a Recently Emerged Seal Influenza Virus in Mice and Ferrets |
topic_facet |
Vaccines and Antiviral Agents |
description |
H3N8 influenza viruses are a commonly found subtype in wild birds, usually causing mild or no disease in infected birds. However, they have crossed the species barrier and have been associated with outbreaks in dogs, pigs, donkeys, and seals and therefore pose a threat to humans. A live attenuated, cold-adapted (ca) H3N8 vaccine virus was generated by reverse genetics using the wild-type (wt) hemagglutinin (HA) and neuraminidase (NA) genes from the A/blue-winged teal/Texas/Sg-00079/2007 (H3N8) (tl/TX/079/07) wt virus and the six internal protein gene segments from the ca influenza A virus vaccine donor strain, A/Ann Arbor/6/60 ca (H2N2), the backbone of the licensed seasonal live attenuated influenza vaccine. One dose of the tl/TX/079/07 ca vaccine induced a robust neutralizing antibody response against the homologous (tl/TX/079/07) and two heterologous influenza viruses, including the recently emerged A/harbor seal/New Hampshire/179629/2011 (H3N8) and A/northern pintail/Alaska/44228-129/2006 (H3N8) viruses, and conferred robust protection against the homologous and heterologous influenza viruses. We also analyzed human sera against the tl/TX/079/07 H3N8 avian influenza virus and observed low but detectable antibody reactivity in elderly subjects, suggesting that older H3N2 influenza viruses confer some cross-reactive antibody. The latter observation was confirmed in a ferret study. The safety, immunogenicity, and efficacy of the tl/TX/079/07 ca vaccine in mice and ferrets support further evaluation of this vaccine in humans for use in the event of transmission of an H3N8 avian influenza virus to humans. The human and ferret serology data suggest that a single dose of the vaccine may be sufficient in older subjects. |
format |
Text |
author |
Baz, Mariana Paskel, Myeisha Matsuoka, Yumiko Zengel, James R. Cheng, Xing Treanor, John J. Jin, Hong Subbarao, Kanta |
author_facet |
Baz, Mariana Paskel, Myeisha Matsuoka, Yumiko Zengel, James R. Cheng, Xing Treanor, John J. Jin, Hong Subbarao, Kanta |
author_sort |
Baz, Mariana |
title |
A Single Dose of an Avian H3N8 Influenza Virus Vaccine Is Highly Immunogenic and Efficacious against a Recently Emerged Seal Influenza Virus in Mice and Ferrets |
title_short |
A Single Dose of an Avian H3N8 Influenza Virus Vaccine Is Highly Immunogenic and Efficacious against a Recently Emerged Seal Influenza Virus in Mice and Ferrets |
title_full |
A Single Dose of an Avian H3N8 Influenza Virus Vaccine Is Highly Immunogenic and Efficacious against a Recently Emerged Seal Influenza Virus in Mice and Ferrets |
title_fullStr |
A Single Dose of an Avian H3N8 Influenza Virus Vaccine Is Highly Immunogenic and Efficacious against a Recently Emerged Seal Influenza Virus in Mice and Ferrets |
title_full_unstemmed |
A Single Dose of an Avian H3N8 Influenza Virus Vaccine Is Highly Immunogenic and Efficacious against a Recently Emerged Seal Influenza Virus in Mice and Ferrets |
title_sort |
single dose of an avian h3n8 influenza virus vaccine is highly immunogenic and efficacious against a recently emerged seal influenza virus in mice and ferrets |
publisher |
American Society for Microbiology |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468475/ http://www.ncbi.nlm.nih.gov/pubmed/25903333 https://doi.org/10.1128/JVI.00280-15 |
genre |
harbor seal Alaska |
genre_facet |
harbor seal Alaska |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468475/ http://www.ncbi.nlm.nih.gov/pubmed/25903333 http://dx.doi.org/10.1128/JVI.00280-15 |
op_rights |
Copyright © 2015, American Society for Microbiology. All Rights Reserved. |
op_doi |
https://doi.org/10.1128/JVI.00280-15 |
container_title |
Journal of Virology |
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89 |
container_issue |
13 |
container_start_page |
6907 |
op_container_end_page |
6917 |
_version_ |
1766022885969756160 |