Sequence Analysis of Bitter Taste Receptor Gene Repertoires in Different Ruminant Species
Bitter taste has been extensively studied in mammalian species and is associated with sensitivity to toxins and with food choices that avoid dangerous substances in the diet. At the molecular level, bitter compounds are sensed by bitter taste receptor proteins (T2R) present at the surface of taste r...
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ftpubmed:oai:pubmedcentral.nih.gov:4465170 2023-05-15T17:13:41+02:00 Sequence Analysis of Bitter Taste Receptor Gene Repertoires in Different Ruminant Species Monteiro Ferreira, Ana Tomás Marques, Andreia Bhide, Mangesh Cubric-Curik, Vlatka Hollung, Kristin Knight, Christopher Harold Raundrup, Katrine Lippolis, John Palmer, Mitchell Sales-Baptista, Elvira Araújo, Susana Sousa de Almeida, André Martinho 2015-06-10 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465170/ http://www.ncbi.nlm.nih.gov/pubmed/26061084 https://doi.org/10.1371/journal.pone.0124933 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465170/ http://www.ncbi.nlm.nih.gov/pubmed/26061084 http://dx.doi.org/10.1371/journal.pone.0124933 https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication CC0 PDM Research Article Text 2015 ftpubmed https://doi.org/10.1371/journal.pone.0124933 2015-07-05T00:14:27Z Bitter taste has been extensively studied in mammalian species and is associated with sensitivity to toxins and with food choices that avoid dangerous substances in the diet. At the molecular level, bitter compounds are sensed by bitter taste receptor proteins (T2R) present at the surface of taste receptor cells in the gustatory papillae. Our work aims at exploring the phylogenetic relationships of T2R gene sequences within different ruminant species. To accomplish this goal, we gathered a collection of ruminant species with different feeding behaviors and for which no genome data is available: American bison, chamois, elk, European bison, fallow deer, goat, moose, mouflon, muskox, red deer, reindeer and white tailed deer. The herbivores chosen for this study belong to different taxonomic families and habitats, and hence, exhibit distinct foraging behaviors and diet preferences. We describe the first partial repertoires of T2R gene sequences for these species obtained by direct sequencing. We then consider the homology and evolutionary history of these receptors within this ruminant group, and whether it relates to feeding type classification, using MEGA software. Our results suggest that phylogenetic proximity of T2R genes corresponds more to the traditional taxonomic groups of the species rather than reflecting a categorization by feeding strategy. Text muskox PubMed Central (PMC) PLOS ONE 10 6 e0124933 |
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Research Article Monteiro Ferreira, Ana Tomás Marques, Andreia Bhide, Mangesh Cubric-Curik, Vlatka Hollung, Kristin Knight, Christopher Harold Raundrup, Katrine Lippolis, John Palmer, Mitchell Sales-Baptista, Elvira Araújo, Susana Sousa de Almeida, André Martinho Sequence Analysis of Bitter Taste Receptor Gene Repertoires in Different Ruminant Species |
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Research Article |
description |
Bitter taste has been extensively studied in mammalian species and is associated with sensitivity to toxins and with food choices that avoid dangerous substances in the diet. At the molecular level, bitter compounds are sensed by bitter taste receptor proteins (T2R) present at the surface of taste receptor cells in the gustatory papillae. Our work aims at exploring the phylogenetic relationships of T2R gene sequences within different ruminant species. To accomplish this goal, we gathered a collection of ruminant species with different feeding behaviors and for which no genome data is available: American bison, chamois, elk, European bison, fallow deer, goat, moose, mouflon, muskox, red deer, reindeer and white tailed deer. The herbivores chosen for this study belong to different taxonomic families and habitats, and hence, exhibit distinct foraging behaviors and diet preferences. We describe the first partial repertoires of T2R gene sequences for these species obtained by direct sequencing. We then consider the homology and evolutionary history of these receptors within this ruminant group, and whether it relates to feeding type classification, using MEGA software. Our results suggest that phylogenetic proximity of T2R genes corresponds more to the traditional taxonomic groups of the species rather than reflecting a categorization by feeding strategy. |
format |
Text |
author |
Monteiro Ferreira, Ana Tomás Marques, Andreia Bhide, Mangesh Cubric-Curik, Vlatka Hollung, Kristin Knight, Christopher Harold Raundrup, Katrine Lippolis, John Palmer, Mitchell Sales-Baptista, Elvira Araújo, Susana Sousa de Almeida, André Martinho |
author_facet |
Monteiro Ferreira, Ana Tomás Marques, Andreia Bhide, Mangesh Cubric-Curik, Vlatka Hollung, Kristin Knight, Christopher Harold Raundrup, Katrine Lippolis, John Palmer, Mitchell Sales-Baptista, Elvira Araújo, Susana Sousa de Almeida, André Martinho |
author_sort |
Monteiro Ferreira, Ana |
title |
Sequence Analysis of Bitter Taste Receptor Gene Repertoires in Different Ruminant Species |
title_short |
Sequence Analysis of Bitter Taste Receptor Gene Repertoires in Different Ruminant Species |
title_full |
Sequence Analysis of Bitter Taste Receptor Gene Repertoires in Different Ruminant Species |
title_fullStr |
Sequence Analysis of Bitter Taste Receptor Gene Repertoires in Different Ruminant Species |
title_full_unstemmed |
Sequence Analysis of Bitter Taste Receptor Gene Repertoires in Different Ruminant Species |
title_sort |
sequence analysis of bitter taste receptor gene repertoires in different ruminant species |
publisher |
Public Library of Science |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465170/ http://www.ncbi.nlm.nih.gov/pubmed/26061084 https://doi.org/10.1371/journal.pone.0124933 |
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muskox |
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muskox |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465170/ http://www.ncbi.nlm.nih.gov/pubmed/26061084 http://dx.doi.org/10.1371/journal.pone.0124933 |
op_rights |
https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication |
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CC0 PDM |
op_doi |
https://doi.org/10.1371/journal.pone.0124933 |
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PLOS ONE |
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10 |
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6 |
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e0124933 |
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