Plasma FGF21 Concentrations, Adipose Fibroblast Growth Factor Receptor-1 and β-Klotho Expression Decrease with Fasting in Northern Elephant Seals
Fibroblast growth factor (FGF)-21 is secreted from the liver, pancreas, and adipose in response to prolonged fasting/starvation to facilitate lipid and glucose metabolism. Northern elephant seals naturally fast for several months, maintaining a relatively elevated metabolic rate to satisfy their ene...
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ftpubmed:oai:pubmedcentral.nih.gov:4457680 2023-05-15T16:05:19+02:00 Plasma FGF21 Concentrations, Adipose Fibroblast Growth Factor Receptor-1 and β-Klotho Expression Decrease with Fasting in Northern Elephant Seals Suzuki, Miwa Lee, Andrew Vázquez-Medina, Jose Pablo Viscarra, Jose A. Crocker, Daniel E. Ortiz, Rudy M. 2015-04-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457680/ http://www.ncbi.nlm.nih.gov/pubmed/25857751 https://doi.org/10.1016/j.ygcen.2015.03.009 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457680/ http://www.ncbi.nlm.nih.gov/pubmed/25857751 http://dx.doi.org/10.1016/j.ygcen.2015.03.009 © 2015 Published by Elsevier Inc. Article Text 2015 ftpubmed https://doi.org/10.1016/j.ygcen.2015.03.009 2016-05-22T00:01:39Z Fibroblast growth factor (FGF)-21 is secreted from the liver, pancreas, and adipose in response to prolonged fasting/starvation to facilitate lipid and glucose metabolism. Northern elephant seals naturally fast for several months, maintaining a relatively elevated metabolic rate to satisfy their energetic requirements. Thus, to better understand the impact of prolonged food deprivation on FGF21-associated changes, we analyzed the expression of FGF21, FGF receptor-1 (FGFR1), β-klotho (KLB; a co-activator of FGFR) in adipose, and plasma FGF21, glucose and 3-hydroxybutyrate in fasted elephant seal pups. Expression of FGFR1 and KLB mRNA decreased 98% and 43%, respectively, with fasting duration. While the 80% decrease in mean adipose FGF21 mRNA expression with fasting did not reach statistical significance, it paralleled the 39% decrease in plasma FGF21 concentrations suggesting that FGF21 is suppressed with fasting in elephant seals. Data demonstrate an atypical response of FGF21 to prolonged fasting in a mammal suggesting that FGF21-mediated mechanisms have evolved differentially in elephant seals. Furthermore, the typical fasting-induced, FGF21-mediated actions such as the inhibition of lipolysis in adipose may not be required in elephant seals as part of a naturally adapted mechanism to support their unique metabolic demands during prolonged fasting. Text Elephant Seal Elephant Seals PubMed Central (PMC) General and Comparative Endocrinology 216 86 89 |
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Article Suzuki, Miwa Lee, Andrew Vázquez-Medina, Jose Pablo Viscarra, Jose A. Crocker, Daniel E. Ortiz, Rudy M. Plasma FGF21 Concentrations, Adipose Fibroblast Growth Factor Receptor-1 and β-Klotho Expression Decrease with Fasting in Northern Elephant Seals |
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Fibroblast growth factor (FGF)-21 is secreted from the liver, pancreas, and adipose in response to prolonged fasting/starvation to facilitate lipid and glucose metabolism. Northern elephant seals naturally fast for several months, maintaining a relatively elevated metabolic rate to satisfy their energetic requirements. Thus, to better understand the impact of prolonged food deprivation on FGF21-associated changes, we analyzed the expression of FGF21, FGF receptor-1 (FGFR1), β-klotho (KLB; a co-activator of FGFR) in adipose, and plasma FGF21, glucose and 3-hydroxybutyrate in fasted elephant seal pups. Expression of FGFR1 and KLB mRNA decreased 98% and 43%, respectively, with fasting duration. While the 80% decrease in mean adipose FGF21 mRNA expression with fasting did not reach statistical significance, it paralleled the 39% decrease in plasma FGF21 concentrations suggesting that FGF21 is suppressed with fasting in elephant seals. Data demonstrate an atypical response of FGF21 to prolonged fasting in a mammal suggesting that FGF21-mediated mechanisms have evolved differentially in elephant seals. Furthermore, the typical fasting-induced, FGF21-mediated actions such as the inhibition of lipolysis in adipose may not be required in elephant seals as part of a naturally adapted mechanism to support their unique metabolic demands during prolonged fasting. |
format |
Text |
author |
Suzuki, Miwa Lee, Andrew Vázquez-Medina, Jose Pablo Viscarra, Jose A. Crocker, Daniel E. Ortiz, Rudy M. |
author_facet |
Suzuki, Miwa Lee, Andrew Vázquez-Medina, Jose Pablo Viscarra, Jose A. Crocker, Daniel E. Ortiz, Rudy M. |
author_sort |
Suzuki, Miwa |
title |
Plasma FGF21 Concentrations, Adipose Fibroblast Growth Factor Receptor-1 and β-Klotho Expression Decrease with Fasting in Northern Elephant Seals |
title_short |
Plasma FGF21 Concentrations, Adipose Fibroblast Growth Factor Receptor-1 and β-Klotho Expression Decrease with Fasting in Northern Elephant Seals |
title_full |
Plasma FGF21 Concentrations, Adipose Fibroblast Growth Factor Receptor-1 and β-Klotho Expression Decrease with Fasting in Northern Elephant Seals |
title_fullStr |
Plasma FGF21 Concentrations, Adipose Fibroblast Growth Factor Receptor-1 and β-Klotho Expression Decrease with Fasting in Northern Elephant Seals |
title_full_unstemmed |
Plasma FGF21 Concentrations, Adipose Fibroblast Growth Factor Receptor-1 and β-Klotho Expression Decrease with Fasting in Northern Elephant Seals |
title_sort |
plasma fgf21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457680/ http://www.ncbi.nlm.nih.gov/pubmed/25857751 https://doi.org/10.1016/j.ygcen.2015.03.009 |
genre |
Elephant Seal Elephant Seals |
genre_facet |
Elephant Seal Elephant Seals |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457680/ http://www.ncbi.nlm.nih.gov/pubmed/25857751 http://dx.doi.org/10.1016/j.ygcen.2015.03.009 |
op_rights |
© 2015 Published by Elsevier Inc. |
op_doi |
https://doi.org/10.1016/j.ygcen.2015.03.009 |
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General and Comparative Endocrinology |
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216 |
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86 |
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89 |
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1766401219935338496 |