Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review
Birth cohort designs are useful in studying adult disease trajectories and outcomes, such as schizophrenia. We review the schizophrenia research performed in the Northern Finland Birth Cohort 1966 (NFBC 1966), which includes 10,934 individuals living in Finland at 16 years of age who have been monit...
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ftpubmed:oai:pubmedcentral.nih.gov:4452001 2023-05-15T17:42:16+02:00 Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review Jääskeläinen, Erika Haapea, Marianne Rautio, Nina Juola, Pauliina Penttilä, Matti Nordström, Tanja Rissanen, Ina Husa, Anja Keskinen, Emmi Marttila, Riikka Filatova, Svetlana Paaso, Tiina-Mari Koivukangas, Jenni Moilanen, Kristiina Isohanni, Matti Miettunen, Jouko 2015 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452001/ http://www.ncbi.nlm.nih.gov/pubmed/26090224 https://doi.org/10.1155/2015/524875 en eng Hindawi Publishing Corporation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452001/ http://www.ncbi.nlm.nih.gov/pubmed/26090224 http://dx.doi.org/10.1155/2015/524875 Copyright © 2015 Erika Jääskeläinen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Review Article Text 2015 ftpubmed https://doi.org/10.1155/2015/524875 2015-07-05T00:05:07Z Birth cohort designs are useful in studying adult disease trajectories and outcomes, such as schizophrenia. We review the schizophrenia research performed in the Northern Finland Birth Cohort 1966 (NFBC 1966), which includes 10,934 individuals living in Finland at 16 years of age who have been monitored since each mother's mid-pregnancy. By the age of 44, 150 (1.4%) had developed schizophrenia. There are 77 original papers on schizophrenia published from the NFBC 1966. The early studies have found various risk factors for schizophrenia, especially related to pregnancy and perinatal phase. Psychiatric and somatic outcomes were heterogeneous, but relatively poor. Mortality in schizophrenia is high, especially due to suicides. Several early predictors of outcomes have also been found. Individuals with schizophrenia have alterations in brain morphometry and neurocognition, and our latest studies have found that the use of high lifetime doses of antipsychotics associated with these changes. The schizophrenia research in the NFBC 1966 has been especially active for 20 years, the prospective study design and long follow-up enabling several clinically and epidemiologically important findings. When compared to other birth cohorts, the research in the NFBC 1966 has offered also unique findings on course and outcome of schizophrenia. Text Northern Finland PubMed Central (PMC) Schizophrenia Research and Treatment 2015 1 12 |
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Review Article Jääskeläinen, Erika Haapea, Marianne Rautio, Nina Juola, Pauliina Penttilä, Matti Nordström, Tanja Rissanen, Ina Husa, Anja Keskinen, Emmi Marttila, Riikka Filatova, Svetlana Paaso, Tiina-Mari Koivukangas, Jenni Moilanen, Kristiina Isohanni, Matti Miettunen, Jouko Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review |
topic_facet |
Review Article |
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Birth cohort designs are useful in studying adult disease trajectories and outcomes, such as schizophrenia. We review the schizophrenia research performed in the Northern Finland Birth Cohort 1966 (NFBC 1966), which includes 10,934 individuals living in Finland at 16 years of age who have been monitored since each mother's mid-pregnancy. By the age of 44, 150 (1.4%) had developed schizophrenia. There are 77 original papers on schizophrenia published from the NFBC 1966. The early studies have found various risk factors for schizophrenia, especially related to pregnancy and perinatal phase. Psychiatric and somatic outcomes were heterogeneous, but relatively poor. Mortality in schizophrenia is high, especially due to suicides. Several early predictors of outcomes have also been found. Individuals with schizophrenia have alterations in brain morphometry and neurocognition, and our latest studies have found that the use of high lifetime doses of antipsychotics associated with these changes. The schizophrenia research in the NFBC 1966 has been especially active for 20 years, the prospective study design and long follow-up enabling several clinically and epidemiologically important findings. When compared to other birth cohorts, the research in the NFBC 1966 has offered also unique findings on course and outcome of schizophrenia. |
format |
Text |
author |
Jääskeläinen, Erika Haapea, Marianne Rautio, Nina Juola, Pauliina Penttilä, Matti Nordström, Tanja Rissanen, Ina Husa, Anja Keskinen, Emmi Marttila, Riikka Filatova, Svetlana Paaso, Tiina-Mari Koivukangas, Jenni Moilanen, Kristiina Isohanni, Matti Miettunen, Jouko |
author_facet |
Jääskeläinen, Erika Haapea, Marianne Rautio, Nina Juola, Pauliina Penttilä, Matti Nordström, Tanja Rissanen, Ina Husa, Anja Keskinen, Emmi Marttila, Riikka Filatova, Svetlana Paaso, Tiina-Mari Koivukangas, Jenni Moilanen, Kristiina Isohanni, Matti Miettunen, Jouko |
author_sort |
Jääskeläinen, Erika |
title |
Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review |
title_short |
Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review |
title_full |
Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review |
title_fullStr |
Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review |
title_full_unstemmed |
Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review |
title_sort |
twenty years of schizophrenia research in the northern finland birth cohort 1966: a systematic review |
publisher |
Hindawi Publishing Corporation |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452001/ http://www.ncbi.nlm.nih.gov/pubmed/26090224 https://doi.org/10.1155/2015/524875 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452001/ http://www.ncbi.nlm.nih.gov/pubmed/26090224 http://dx.doi.org/10.1155/2015/524875 |
op_rights |
Copyright © 2015 Erika Jääskeläinen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1155/2015/524875 |
container_title |
Schizophrenia Research and Treatment |
container_volume |
2015 |
container_start_page |
1 |
op_container_end_page |
12 |
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1766144115793199104 |