Sea Cucumbers Metabolites as Potent Anti-Cancer Agents
Sea cucumbers and their extracts have gained immense popularity and interest among researchers and nutritionists due to their nutritive value, potential health benefits, and use in the treatment of chronic inflammatory diseases. Many areas of the world use sea cucumbers in traditional foods and folk...
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ftpubmed:oai:pubmedcentral.nih.gov:4446612 2023-05-15T15:59:38+02:00 Sea Cucumbers Metabolites as Potent Anti-Cancer Agents Janakiram, Naveena B. Mohammed, Altaf Rao, Chinthalapally V. 2015-05-12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446612/ http://www.ncbi.nlm.nih.gov/pubmed/25984989 https://doi.org/10.3390/md13052909 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446612/ http://www.ncbi.nlm.nih.gov/pubmed/25984989 http://dx.doi.org/10.3390/md13052909 © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). CC-BY Review Text 2015 ftpubmed https://doi.org/10.3390/md13052909 2015-05-31T00:09:28Z Sea cucumbers and their extracts have gained immense popularity and interest among researchers and nutritionists due to their nutritive value, potential health benefits, and use in the treatment of chronic inflammatory diseases. Many areas of the world use sea cucumbers in traditional foods and folk medicine. Though the actual components and their specific functions still remain to be investigated, most sea cucumber extracts are being studied for their anti-inflammatory functions, immunostimulatory properties, and for cancer prevention and treatment. There is large scope for the discovery of additional bioactive, valuable compounds from this natural source. Sea cucumber extracts contain unique components, such as modified triterpene glycosides, sulfated polysaccharides, glycosphingolipids, and esterified phospholipids. Frondanol A5, an isopropyl alcohol/water extract of the enzymatically hydrolyzed epithelia of the edible North Atlantic sea cucumber, Cucumaria frondosa, contains monosulfated triterpenoid glycoside Frondoside A, the disulfated glycoside Frondoside B, the trisulfated glycoside Frondoside C, 12-methyltetradecanoic acid, eicosapentaenoic acid, and fucosylated chondroitin sulfate. We have extensively studied the efficacy of this extract in preventing colon cancer in rodent models. In this review, we discuss the anti-inflammatory, immunostimulatory, and anti-tumor properties of sea cucumber extracts. Text Cucumaria frondosa North Atlantic PubMed Central (PMC) Marine Drugs 13 5 2909 2923 |
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Review Janakiram, Naveena B. Mohammed, Altaf Rao, Chinthalapally V. Sea Cucumbers Metabolites as Potent Anti-Cancer Agents |
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Review |
description |
Sea cucumbers and their extracts have gained immense popularity and interest among researchers and nutritionists due to their nutritive value, potential health benefits, and use in the treatment of chronic inflammatory diseases. Many areas of the world use sea cucumbers in traditional foods and folk medicine. Though the actual components and their specific functions still remain to be investigated, most sea cucumber extracts are being studied for their anti-inflammatory functions, immunostimulatory properties, and for cancer prevention and treatment. There is large scope for the discovery of additional bioactive, valuable compounds from this natural source. Sea cucumber extracts contain unique components, such as modified triterpene glycosides, sulfated polysaccharides, glycosphingolipids, and esterified phospholipids. Frondanol A5, an isopropyl alcohol/water extract of the enzymatically hydrolyzed epithelia of the edible North Atlantic sea cucumber, Cucumaria frondosa, contains monosulfated triterpenoid glycoside Frondoside A, the disulfated glycoside Frondoside B, the trisulfated glycoside Frondoside C, 12-methyltetradecanoic acid, eicosapentaenoic acid, and fucosylated chondroitin sulfate. We have extensively studied the efficacy of this extract in preventing colon cancer in rodent models. In this review, we discuss the anti-inflammatory, immunostimulatory, and anti-tumor properties of sea cucumber extracts. |
format |
Text |
author |
Janakiram, Naveena B. Mohammed, Altaf Rao, Chinthalapally V. |
author_facet |
Janakiram, Naveena B. Mohammed, Altaf Rao, Chinthalapally V. |
author_sort |
Janakiram, Naveena B. |
title |
Sea Cucumbers Metabolites as Potent Anti-Cancer Agents |
title_short |
Sea Cucumbers Metabolites as Potent Anti-Cancer Agents |
title_full |
Sea Cucumbers Metabolites as Potent Anti-Cancer Agents |
title_fullStr |
Sea Cucumbers Metabolites as Potent Anti-Cancer Agents |
title_full_unstemmed |
Sea Cucumbers Metabolites as Potent Anti-Cancer Agents |
title_sort |
sea cucumbers metabolites as potent anti-cancer agents |
publisher |
MDPI |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446612/ http://www.ncbi.nlm.nih.gov/pubmed/25984989 https://doi.org/10.3390/md13052909 |
genre |
Cucumaria frondosa North Atlantic |
genre_facet |
Cucumaria frondosa North Atlantic |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446612/ http://www.ncbi.nlm.nih.gov/pubmed/25984989 http://dx.doi.org/10.3390/md13052909 |
op_rights |
© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/md13052909 |
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Marine Drugs |
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13 |
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5 |
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2909 |
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2923 |
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