Cardiometabolic Risk Factors in Young Adults Who Were Born Preterm
Adults who were born preterm with a very low birth weight have higher blood pressure and impaired glucose regulation later in life compared with those born at term. We investigated cardiometabolic risk factors in young adults who were born at any degree of prematurity in the Preterm Birth and Early...
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ftpubmed:oai:pubmedcentral.nih.gov:4445394 2023-05-15T17:42:44+02:00 Cardiometabolic Risk Factors in Young Adults Who Were Born Preterm Sipola-Leppänen, Marika Vääräsmäki, Marja Tikanmäki, Marjaana Matinolli, Hanna-Maria Miettola, Satu Hovi, Petteri Wehkalampi, Karoliina Ruokonen, Aimo Sundvall, Jouko Pouta, Anneli Eriksson, Johan G. Järvelin, Marjo-Riitta Kajantie, Eero 2015-06-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445394/ http://www.ncbi.nlm.nih.gov/pubmed/25947956 https://doi.org/10.1093/aje/kwu443 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445394/ http://www.ncbi.nlm.nih.gov/pubmed/25947956 http://dx.doi.org/10.1093/aje/kwu443 © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Original Contributions Text 2015 ftpubmed https://doi.org/10.1093/aje/kwu443 2015-05-31T00:08:36Z Adults who were born preterm with a very low birth weight have higher blood pressure and impaired glucose regulation later in life compared with those born at term. We investigated cardiometabolic risk factors in young adults who were born at any degree of prematurity in the Preterm Birth and Early Life Programming of Adult Health and Disease (ESTER) Study, a population-based cohort study of individuals born in 1985–1989 in Northern Finland. In 2009–2011, 3 groups underwent clinical examination: 134 participants born at less than 34 gestational weeks (early preterm), 242 born at 34–36 weeks (late preterm), and 344 born at 37 weeks or later (controls). Compared with controls, adults who were born preterm had higher body fat percentages (after adjustment for sex, age, and cohort (1985–1986 or 1987–1989), for those born early preterm, difference = 6.2%, 95% confidence interval (CI): 0.4, 13.2; for those born late preterm, difference = 8.0%, 95% CI: 2.4, 13.8), waist circumferences, blood pressure (for those born early preterm, difference = 3.0 mm Hg, 95% CI: 0.9, 5.1; for those born late preterm, difference = 1.7, 95% CI: −0.1, 3.4), plasma uric acid levels (for those born early preterm, difference = 20.1%, 95% CI: 7.9, 32.3; for those born late preterm, difference = 20.2%, 95% CI: 10.7, 30.5), alanine aminotransferase levels, and aspartate transaminase levels. They were also more likely to have metabolic syndrome (for those born early preterm, odds ratio = 3.7, 95% CI: 1.6, 8.2; for those born late preterm, odds ratio = 2.5, 95% CI: 1.2, 5.3). Elevated levels of conventional and emerging risk factors suggest a higher risk of cardiometabolic disease later in life. These risk factors are also present in the large group of adults born late preterm. Text Northern Finland PubMed Central (PMC) American Journal of Epidemiology 181 11 861 873 |
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Original Contributions Sipola-Leppänen, Marika Vääräsmäki, Marja Tikanmäki, Marjaana Matinolli, Hanna-Maria Miettola, Satu Hovi, Petteri Wehkalampi, Karoliina Ruokonen, Aimo Sundvall, Jouko Pouta, Anneli Eriksson, Johan G. Järvelin, Marjo-Riitta Kajantie, Eero Cardiometabolic Risk Factors in Young Adults Who Were Born Preterm |
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Original Contributions |
description |
Adults who were born preterm with a very low birth weight have higher blood pressure and impaired glucose regulation later in life compared with those born at term. We investigated cardiometabolic risk factors in young adults who were born at any degree of prematurity in the Preterm Birth and Early Life Programming of Adult Health and Disease (ESTER) Study, a population-based cohort study of individuals born in 1985–1989 in Northern Finland. In 2009–2011, 3 groups underwent clinical examination: 134 participants born at less than 34 gestational weeks (early preterm), 242 born at 34–36 weeks (late preterm), and 344 born at 37 weeks or later (controls). Compared with controls, adults who were born preterm had higher body fat percentages (after adjustment for sex, age, and cohort (1985–1986 or 1987–1989), for those born early preterm, difference = 6.2%, 95% confidence interval (CI): 0.4, 13.2; for those born late preterm, difference = 8.0%, 95% CI: 2.4, 13.8), waist circumferences, blood pressure (for those born early preterm, difference = 3.0 mm Hg, 95% CI: 0.9, 5.1; for those born late preterm, difference = 1.7, 95% CI: −0.1, 3.4), plasma uric acid levels (for those born early preterm, difference = 20.1%, 95% CI: 7.9, 32.3; for those born late preterm, difference = 20.2%, 95% CI: 10.7, 30.5), alanine aminotransferase levels, and aspartate transaminase levels. They were also more likely to have metabolic syndrome (for those born early preterm, odds ratio = 3.7, 95% CI: 1.6, 8.2; for those born late preterm, odds ratio = 2.5, 95% CI: 1.2, 5.3). Elevated levels of conventional and emerging risk factors suggest a higher risk of cardiometabolic disease later in life. These risk factors are also present in the large group of adults born late preterm. |
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Text |
author |
Sipola-Leppänen, Marika Vääräsmäki, Marja Tikanmäki, Marjaana Matinolli, Hanna-Maria Miettola, Satu Hovi, Petteri Wehkalampi, Karoliina Ruokonen, Aimo Sundvall, Jouko Pouta, Anneli Eriksson, Johan G. Järvelin, Marjo-Riitta Kajantie, Eero |
author_facet |
Sipola-Leppänen, Marika Vääräsmäki, Marja Tikanmäki, Marjaana Matinolli, Hanna-Maria Miettola, Satu Hovi, Petteri Wehkalampi, Karoliina Ruokonen, Aimo Sundvall, Jouko Pouta, Anneli Eriksson, Johan G. Järvelin, Marjo-Riitta Kajantie, Eero |
author_sort |
Sipola-Leppänen, Marika |
title |
Cardiometabolic Risk Factors in Young Adults Who Were Born Preterm |
title_short |
Cardiometabolic Risk Factors in Young Adults Who Were Born Preterm |
title_full |
Cardiometabolic Risk Factors in Young Adults Who Were Born Preterm |
title_fullStr |
Cardiometabolic Risk Factors in Young Adults Who Were Born Preterm |
title_full_unstemmed |
Cardiometabolic Risk Factors in Young Adults Who Were Born Preterm |
title_sort |
cardiometabolic risk factors in young adults who were born preterm |
publisher |
Oxford University Press |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445394/ http://www.ncbi.nlm.nih.gov/pubmed/25947956 https://doi.org/10.1093/aje/kwu443 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445394/ http://www.ncbi.nlm.nih.gov/pubmed/25947956 http://dx.doi.org/10.1093/aje/kwu443 |
op_rights |
© The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/aje/kwu443 |
container_title |
American Journal of Epidemiology |
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181 |
container_issue |
11 |
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861 |
op_container_end_page |
873 |
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1766144636884090880 |