A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer
Several published studies identified associations of a number of polymorphisms with a variety of survival outcomes in colorectal cancer. In this study, we aimed to explore 102 previously reported common genetic polymorphisms and their associations with overall survival (OS) and disease-free survival...
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ftpubmed:oai:pubmedcentral.nih.gov:4443940 2023-05-15T17:22:22+02:00 A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer Savas, Sevtap Xu, Jingxiong Werdyani, Salem Shestopaloff, Konstantin Dicks, Elizabeth Green, Jane Parfrey, Patrick Green, Roger Xu, Wei 2015 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443940/ https://doi.org/10.1155/2015/968743 en eng Hindawi Publishing Corporation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443940/ http://dx.doi.org/10.1155/2015/968743 Copyright © 2015 Sevtap Savas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Research Article Text 2015 ftpubmed https://doi.org/10.1155/2015/968743 2015-06-14T00:03:12Z Several published studies identified associations of a number of polymorphisms with a variety of survival outcomes in colorectal cancer. In this study, we aimed to explore 102 previously reported common genetic polymorphisms and their associations with overall survival (OS) and disease-free survival (DFS) in a colorectal cancer patient cohort from Newfoundland (n = 505). Genotypes were obtained using a genomewide SNP genotyping platform. For each polymorphism, the best possible genetic model was estimated for both overall survival and disease-free survival using a previously published approach. These SNPs were then analyzed under their genetic models by Cox regression method. Correction for multiple comparisons was performed by the False Discovery Rate (FDR) method. Univariate analysis results showed that RRM1-rs12806698, IFNGR1-rs1327474, DDX20-rs197412, and PTGS2-rs5275 polymorphisms were nominally associated with OS or DFS (p < 0.01). In stage-adjusted analysis, the nominal associations of DDX20-rs197412, PTGS2-rs5275, and HSPA5-rs391957 with DFS were detected. However, after FDR correction none of these polymorphisms remained significantly associated with the survival outcomes. We conclude that polymorphisms investigated in this study are not associated with OS or DFS in our colorectal cancer patient cohort. Text Newfoundland PubMed Central (PMC) BioMed Research International 2015 1 9 |
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Research Article Savas, Sevtap Xu, Jingxiong Werdyani, Salem Shestopaloff, Konstantin Dicks, Elizabeth Green, Jane Parfrey, Patrick Green, Roger Xu, Wei A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer |
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Research Article |
description |
Several published studies identified associations of a number of polymorphisms with a variety of survival outcomes in colorectal cancer. In this study, we aimed to explore 102 previously reported common genetic polymorphisms and their associations with overall survival (OS) and disease-free survival (DFS) in a colorectal cancer patient cohort from Newfoundland (n = 505). Genotypes were obtained using a genomewide SNP genotyping platform. For each polymorphism, the best possible genetic model was estimated for both overall survival and disease-free survival using a previously published approach. These SNPs were then analyzed under their genetic models by Cox regression method. Correction for multiple comparisons was performed by the False Discovery Rate (FDR) method. Univariate analysis results showed that RRM1-rs12806698, IFNGR1-rs1327474, DDX20-rs197412, and PTGS2-rs5275 polymorphisms were nominally associated with OS or DFS (p < 0.01). In stage-adjusted analysis, the nominal associations of DDX20-rs197412, PTGS2-rs5275, and HSPA5-rs391957 with DFS were detected. However, after FDR correction none of these polymorphisms remained significantly associated with the survival outcomes. We conclude that polymorphisms investigated in this study are not associated with OS or DFS in our colorectal cancer patient cohort. |
format |
Text |
author |
Savas, Sevtap Xu, Jingxiong Werdyani, Salem Shestopaloff, Konstantin Dicks, Elizabeth Green, Jane Parfrey, Patrick Green, Roger Xu, Wei |
author_facet |
Savas, Sevtap Xu, Jingxiong Werdyani, Salem Shestopaloff, Konstantin Dicks, Elizabeth Green, Jane Parfrey, Patrick Green, Roger Xu, Wei |
author_sort |
Savas, Sevtap |
title |
A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer |
title_short |
A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer |
title_full |
A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer |
title_fullStr |
A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer |
title_full_unstemmed |
A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer |
title_sort |
survival association study of 102 polymorphisms previously associated with survival outcomes in colorectal cancer |
publisher |
Hindawi Publishing Corporation |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443940/ https://doi.org/10.1155/2015/968743 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443940/ http://dx.doi.org/10.1155/2015/968743 |
op_rights |
Copyright © 2015 Sevtap Savas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1155/2015/968743 |
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BioMed Research International |
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2015 |
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1 |
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9 |
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1766108979997442048 |