Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins
The expression of filaggrin and its stepwise proteolytic degradation are critical events in the terminal differentiation of epidermal keratinocytes and in the formation of the skin barrier to the environment. Here, we investigated whether the evolutionary transition from a terrestrial to a fully aqu...
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ftpubmed:oai:pubmedcentral.nih.gov:4437054 2023-05-15T17:12:51+02:00 Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins Strasser, Bettina Mlitz, Veronika Fischer, Heinz Tschachler, Erwin Eckhart, Leopold 2015-05 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437054/ http://www.ncbi.nlm.nih.gov/pubmed/25739514 https://doi.org/10.1111/exd.12681 en eng Blackwell Publishing Ltd http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437054/ http://www.ncbi.nlm.nih.gov/pubmed/25739514 http://dx.doi.org/10.1111/exd.12681 © 2015 The Authors. Experimental Dermatology Published by John Wiley & Sons Ltd http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. CC-BY Original Articles Text 2015 ftpubmed https://doi.org/10.1111/exd.12681 2015-05-31T00:03:17Z The expression of filaggrin and its stepwise proteolytic degradation are critical events in the terminal differentiation of epidermal keratinocytes and in the formation of the skin barrier to the environment. Here, we investigated whether the evolutionary transition from a terrestrial to a fully aquatic lifestyle of cetaceans, that is dolphins and whales, has been associated with changes in genes encoding filaggrin and proteins involved in the processing of filaggrin. We used comparative genomics, PCRs and re-sequencing of gene segments to screen for the presence and integrity of genes coding for filaggrin and proteases implicated in the maturation of (pro)filaggrin. Filaggrin has been conserved in dolphins (bottlenose dolphin, orca and baiji) but has been lost in whales (sperm whale and minke whale). All other S100 fused-type genes have been lost in cetaceans. Among filaggrin-processing proteases, aspartic peptidase retroviral-like 1 (ASPRV1), also known as saspase, has been conserved, whereas caspase-14 has been lost in all cetaceans investigated. In conclusion, our results suggest that filaggrin is dispensable for the acquisition of fully aquatic lifestyles of whales, whereas it appears to confer an evolutionary advantage to dolphins. The discordant evolution of filaggrin, saspase and caspase-14 in cetaceans indicates that the biological roles of these proteins are not strictly interdependent. Text minke whale Orca Sperm whale PubMed Central (PMC) Experimental Dermatology 24 5 365 369 |
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Original Articles |
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Original Articles Strasser, Bettina Mlitz, Veronika Fischer, Heinz Tschachler, Erwin Eckhart, Leopold Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins |
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Original Articles |
description |
The expression of filaggrin and its stepwise proteolytic degradation are critical events in the terminal differentiation of epidermal keratinocytes and in the formation of the skin barrier to the environment. Here, we investigated whether the evolutionary transition from a terrestrial to a fully aquatic lifestyle of cetaceans, that is dolphins and whales, has been associated with changes in genes encoding filaggrin and proteins involved in the processing of filaggrin. We used comparative genomics, PCRs and re-sequencing of gene segments to screen for the presence and integrity of genes coding for filaggrin and proteases implicated in the maturation of (pro)filaggrin. Filaggrin has been conserved in dolphins (bottlenose dolphin, orca and baiji) but has been lost in whales (sperm whale and minke whale). All other S100 fused-type genes have been lost in cetaceans. Among filaggrin-processing proteases, aspartic peptidase retroviral-like 1 (ASPRV1), also known as saspase, has been conserved, whereas caspase-14 has been lost in all cetaceans investigated. In conclusion, our results suggest that filaggrin is dispensable for the acquisition of fully aquatic lifestyles of whales, whereas it appears to confer an evolutionary advantage to dolphins. The discordant evolution of filaggrin, saspase and caspase-14 in cetaceans indicates that the biological roles of these proteins are not strictly interdependent. |
format |
Text |
author |
Strasser, Bettina Mlitz, Veronika Fischer, Heinz Tschachler, Erwin Eckhart, Leopold |
author_facet |
Strasser, Bettina Mlitz, Veronika Fischer, Heinz Tschachler, Erwin Eckhart, Leopold |
author_sort |
Strasser, Bettina |
title |
Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins |
title_short |
Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins |
title_full |
Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins |
title_fullStr |
Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins |
title_full_unstemmed |
Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins |
title_sort |
comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins |
publisher |
Blackwell Publishing Ltd |
publishDate |
2015 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437054/ http://www.ncbi.nlm.nih.gov/pubmed/25739514 https://doi.org/10.1111/exd.12681 |
genre |
minke whale Orca Sperm whale |
genre_facet |
minke whale Orca Sperm whale |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437054/ http://www.ncbi.nlm.nih.gov/pubmed/25739514 http://dx.doi.org/10.1111/exd.12681 |
op_rights |
© 2015 The Authors. Experimental Dermatology Published by John Wiley & Sons Ltd http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1111/exd.12681 |
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Experimental Dermatology |
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24 |
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5 |
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365 |
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369 |
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1766069729497186304 |