The Timing of Timezyme Diversification in Vertebrates
All biological functions in vertebrates are synchronized with daily and seasonal changes in the environment by the time keeping hormone melatonin. Its nocturnal surge is primarily due to the rhythmic activity of the arylalkylamine N-acetyl transferase AANAT, which thus became the focus of many inves...
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ftpubmed:oai:pubmedcentral.nih.gov:4259306 2023-05-15T15:27:43+02:00 The Timing of Timezyme Diversification in Vertebrates Cazaméa-Catalan, Damien Besseau, Laurence Falcón, Jack Magnanou, Elodie 2014-12-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259306 http://www.ncbi.nlm.nih.gov/pubmed/25486407 https://doi.org/10.1371/journal.pone.0112380 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/25486407 http://dx.doi.org/10.1371/journal.pone.0112380 This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2014 ftpubmed https://doi.org/10.1371/journal.pone.0112380 2014-12-21T00:58:11Z All biological functions in vertebrates are synchronized with daily and seasonal changes in the environment by the time keeping hormone melatonin. Its nocturnal surge is primarily due to the rhythmic activity of the arylalkylamine N-acetyl transferase AANAT, which thus became the focus of many investigations regarding its evolution and function. Various vertebrate isoforms have been reported from cartilaginous fish to mammals but their origin has not been clearly established. Using phylogeny and synteny, we took advantage of the increasing number of available genomes in order to test whether the various rounds of vertebrate whole genome duplications were responsible for the diversification of AANAT. We highlight a gene secondary loss of the AANAT2 in the Sarcopterygii, revealing for the first time that the AAANAT1/2 duplication occurred before the divergence between Actinopterygii (bony fish) and Sarcopterygii (tetrapods, lobe-finned fish, and lungfish). We hypothesize the teleost-specific whole genome duplication (WDG) generated the appearance of the AANAT1a/1b and the AANAT2/2′paralogs, the 2′ isoform being rapidly lost in the teleost common ancestor (ray-finned fish). We also demonstrate the secondary loss of the AANAT1a in a Paracantopterygii (Atlantic cod) and of the 1b in some Ostariophysi (zebrafish and cave fish). Salmonids present an even more diverse set of AANATs that may be due to their specific WGD followed by secondary losses. We propose that vertebrate AANAT diversity resulted from 3 rounds of WGD followed by previously uncharacterized secondary losses. Extant isoforms show subfunctionalized localizations, enzyme activities and affinities that have increased with time since their emergence. Text atlantic cod PubMed Central (PMC) PLoS ONE 9 12 e112380 |
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Research Article Cazaméa-Catalan, Damien Besseau, Laurence Falcón, Jack Magnanou, Elodie The Timing of Timezyme Diversification in Vertebrates |
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Research Article |
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All biological functions in vertebrates are synchronized with daily and seasonal changes in the environment by the time keeping hormone melatonin. Its nocturnal surge is primarily due to the rhythmic activity of the arylalkylamine N-acetyl transferase AANAT, which thus became the focus of many investigations regarding its evolution and function. Various vertebrate isoforms have been reported from cartilaginous fish to mammals but their origin has not been clearly established. Using phylogeny and synteny, we took advantage of the increasing number of available genomes in order to test whether the various rounds of vertebrate whole genome duplications were responsible for the diversification of AANAT. We highlight a gene secondary loss of the AANAT2 in the Sarcopterygii, revealing for the first time that the AAANAT1/2 duplication occurred before the divergence between Actinopterygii (bony fish) and Sarcopterygii (tetrapods, lobe-finned fish, and lungfish). We hypothesize the teleost-specific whole genome duplication (WDG) generated the appearance of the AANAT1a/1b and the AANAT2/2′paralogs, the 2′ isoform being rapidly lost in the teleost common ancestor (ray-finned fish). We also demonstrate the secondary loss of the AANAT1a in a Paracantopterygii (Atlantic cod) and of the 1b in some Ostariophysi (zebrafish and cave fish). Salmonids present an even more diverse set of AANATs that may be due to their specific WGD followed by secondary losses. We propose that vertebrate AANAT diversity resulted from 3 rounds of WGD followed by previously uncharacterized secondary losses. Extant isoforms show subfunctionalized localizations, enzyme activities and affinities that have increased with time since their emergence. |
format |
Text |
author |
Cazaméa-Catalan, Damien Besseau, Laurence Falcón, Jack Magnanou, Elodie |
author_facet |
Cazaméa-Catalan, Damien Besseau, Laurence Falcón, Jack Magnanou, Elodie |
author_sort |
Cazaméa-Catalan, Damien |
title |
The Timing of Timezyme Diversification in Vertebrates |
title_short |
The Timing of Timezyme Diversification in Vertebrates |
title_full |
The Timing of Timezyme Diversification in Vertebrates |
title_fullStr |
The Timing of Timezyme Diversification in Vertebrates |
title_full_unstemmed |
The Timing of Timezyme Diversification in Vertebrates |
title_sort |
timing of timezyme diversification in vertebrates |
publisher |
Public Library of Science |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259306 http://www.ncbi.nlm.nih.gov/pubmed/25486407 https://doi.org/10.1371/journal.pone.0112380 |
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atlantic cod |
genre_facet |
atlantic cod |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/25486407 http://dx.doi.org/10.1371/journal.pone.0112380 |
op_rights |
This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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CC-BY |
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https://doi.org/10.1371/journal.pone.0112380 |
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PLoS ONE |
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9 |
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12 |
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e112380 |
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