Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts

•The transcription factors STAT2 and IRF9 from Atlantic salmon have been identified.•STAT2 co-expressed with STAT1 translocates to the nucleus upon IFN stimulation.•STAT2 are tyrosine phosphorylated upon type I IFN and IFNγ stimulation.•STAT2 and STAT1, as well as IRF9, activates GAS elements upon I...

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Published in:FEBS Open Bio
Main Authors: Sobhkhez, Mehrdad, Skjesol, Astrid, Thomassen, Ernst, Tollersrud, Linn Greiner, Iliev, Dimitar B., Sun, Baojian, Robertsen, Børre, Jørgensen, Jorunn B.
Format: Text
Language:English
Published: Elsevier 2014
Subjects:
Article
Atlantic salmon
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215117
https://doi.org/10.1016/j.fob.2014.09.007
id ftpubmed:oai:pubmedcentral.nih.gov:4215117
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spelling ftpubmed:oai:pubmedcentral.nih.gov:4215117 2023-05-15T15:31:11+02:00 Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts Sobhkhez, Mehrdad Skjesol, Astrid Thomassen, Ernst Tollersrud, Linn Greiner Iliev, Dimitar B. Sun, Baojian Robertsen, Børre Jørgensen, Jorunn B. 2014-10-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215117 https://doi.org/10.1016/j.fob.2014.09.007 en eng Elsevier http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://dx.doi.org/10.1016/j.fob.2014.09.007 © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). CC-BY Article Text 2014 ftpubmed https://doi.org/10.1016/j.fob.2014.09.007 2014-11-09T01:19:08Z •The transcription factors STAT2 and IRF9 from Atlantic salmon have been identified.•STAT2 co-expressed with STAT1 translocates to the nucleus upon IFN stimulation.•STAT2 are tyrosine phosphorylated upon type I IFN and IFNγ stimulation.•STAT2 and STAT1, as well as IRF9, activates GAS elements upon IFNγ stimulation.•Our results suggest novel roles of salmon STAT2 and IRF9 in IFNγ-mediated signaling. Text Atlantic salmon PubMed Central (PMC) FEBS Open Bio 4 1 858 871
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Article
spellingShingle Article
Sobhkhez, Mehrdad
Skjesol, Astrid
Thomassen, Ernst
Tollersrud, Linn Greiner
Iliev, Dimitar B.
Sun, Baojian
Robertsen, Børre
Jørgensen, Jorunn B.
Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
topic_facet Article
description •The transcription factors STAT2 and IRF9 from Atlantic salmon have been identified.•STAT2 co-expressed with STAT1 translocates to the nucleus upon IFN stimulation.•STAT2 are tyrosine phosphorylated upon type I IFN and IFNγ stimulation.•STAT2 and STAT1, as well as IRF9, activates GAS elements upon IFNγ stimulation.•Our results suggest novel roles of salmon STAT2 and IRF9 in IFNγ-mediated signaling.
format Text
author Sobhkhez, Mehrdad
Skjesol, Astrid
Thomassen, Ernst
Tollersrud, Linn Greiner
Iliev, Dimitar B.
Sun, Baojian
Robertsen, Børre
Jørgensen, Jorunn B.
author_facet Sobhkhez, Mehrdad
Skjesol, Astrid
Thomassen, Ernst
Tollersrud, Linn Greiner
Iliev, Dimitar B.
Sun, Baojian
Robertsen, Børre
Jørgensen, Jorunn B.
author_sort Sobhkhez, Mehrdad
title Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
title_short Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
title_full Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
title_fullStr Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
title_full_unstemmed Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
title_sort structural and functional characterization of salmon stat1, stat2 and irf9 homologs sheds light on interferon signaling in teleosts
publisher Elsevier
publishDate 2014
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215117
https://doi.org/10.1016/j.fob.2014.09.007
genre Atlantic salmon
genre_facet Atlantic salmon
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC
http://dx.doi.org/10.1016/j.fob.2014.09.007
op_rights © 2014 The Authors
http://creativecommons.org/licenses/by/3.0/
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
op_rightsnorm CC-BY
op_doi https://doi.org/10.1016/j.fob.2014.09.007
container_title FEBS Open Bio
container_volume 4
container_issue 1
container_start_page 858
op_container_end_page 871
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