Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts

•The transcription factors STAT2 and IRF9 from Atlantic salmon have been identified.•STAT2 co-expressed with STAT1 translocates to the nucleus upon IFN stimulation.•STAT2 are tyrosine phosphorylated upon type I IFN and IFNγ stimulation.•STAT2 and STAT1, as well as IRF9, activates GAS elements upon I...

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Bibliographic Details
Published in:FEBS Open Bio
Main Authors: Sobhkhez, Mehrdad, Skjesol, Astrid, Thomassen, Ernst, Tollersrud, Linn Greiner, Iliev, Dimitar B., Sun, Baojian, Robertsen, Børre, Jørgensen, Jorunn B.
Format: Text
Language:English
Published: Elsevier 2014
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Article
Atlantic salmon
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215117
https://doi.org/10.1016/j.fob.2014.09.007
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Summary:•The transcription factors STAT2 and IRF9 from Atlantic salmon have been identified.•STAT2 co-expressed with STAT1 translocates to the nucleus upon IFN stimulation.•STAT2 are tyrosine phosphorylated upon type I IFN and IFNγ stimulation.•STAT2 and STAT1, as well as IRF9, activates GAS elements upon IFNγ stimulation.•Our results suggest novel roles of salmon STAT2 and IRF9 in IFNγ-mediated signaling.

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