Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus
The aim of study was to investigate the toxic effect of triptolide fed in bait on reproduction of male house rat, Rattus rattus. Feeding of cereal based bait containing 0.2% triptolide to male R. rattus for 5 days in no-choice feeding test, leading to mean daily ingestion of 20.45 mg/kg bw of tripto...
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ftpubmed:oai:pubmedcentral.nih.gov:4211135 2023-05-15T18:04:48+02:00 Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus Singla, Neena Challana, Swati 2014 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211135 http://www.ncbi.nlm.nih.gov/pubmed/25374942 https://doi.org/10.1155/2014/879405 en eng Hindawi Publishing Corporation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/25374942 http://dx.doi.org/10.1155/2014/879405 Copyright © 2014 N. Singla and S. Challana. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Research Article Text 2014 ftpubmed https://doi.org/10.1155/2014/879405 2014-11-09T01:13:46Z The aim of study was to investigate the toxic effect of triptolide fed in bait on reproduction of male house rat, Rattus rattus. Feeding of cereal based bait containing 0.2% triptolide to male R. rattus for 5 days in no-choice feeding test, leading to mean daily ingestion of 20.45 mg/kg bw of triptolide, was found effective in significantly (P ≤ 0.05) reducing sperm motility and viability in cauda epididymal fluid by 80.65 and 75.14%, respectively, from that of untreated rats. Pregnancy rates were decreased by 100% in untreated cyclic female rats paired with male rats treated with 0.2% triptolide. Present studies suggest the potential of 0.2% triptolide bait in regulating reproductive output of R. rattus. Text Rattus rattus PubMed Central (PMC) The Scientific World Journal 2014 1 6 |
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Research Article Singla, Neena Challana, Swati Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus |
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Research Article |
description |
The aim of study was to investigate the toxic effect of triptolide fed in bait on reproduction of male house rat, Rattus rattus. Feeding of cereal based bait containing 0.2% triptolide to male R. rattus for 5 days in no-choice feeding test, leading to mean daily ingestion of 20.45 mg/kg bw of triptolide, was found effective in significantly (P ≤ 0.05) reducing sperm motility and viability in cauda epididymal fluid by 80.65 and 75.14%, respectively, from that of untreated rats. Pregnancy rates were decreased by 100% in untreated cyclic female rats paired with male rats treated with 0.2% triptolide. Present studies suggest the potential of 0.2% triptolide bait in regulating reproductive output of R. rattus. |
format |
Text |
author |
Singla, Neena Challana, Swati |
author_facet |
Singla, Neena Challana, Swati |
author_sort |
Singla, Neena |
title |
Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus |
title_short |
Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus |
title_full |
Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus |
title_fullStr |
Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus |
title_full_unstemmed |
Reproductive Toxicity of Triptolide in Male House Rat, Rattus rattus |
title_sort |
reproductive toxicity of triptolide in male house rat, rattus rattus |
publisher |
Hindawi Publishing Corporation |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211135 http://www.ncbi.nlm.nih.gov/pubmed/25374942 https://doi.org/10.1155/2014/879405 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/25374942 http://dx.doi.org/10.1155/2014/879405 |
op_rights |
Copyright © 2014 N. Singla and S. Challana. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1155/2014/879405 |
container_title |
The Scientific World Journal |
container_volume |
2014 |
container_start_page |
1 |
op_container_end_page |
6 |
_version_ |
1766176223336071168 |