Differential plague-transmission dynamics determine Yersinia pestis population genetic structure on local, regional, and global scales
Plague, the disease caused by the bacterium Yersinia pestis, has greatly impacted human civilization. Y. pestis is a successful global pathogen, with active foci on all continents except Australia and Antarctica. Because the Y. pestis genome is highly monomorphic, previous attempts to characterize t...
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ftpubmed:oai:pubmedcentral.nih.gov:420407 2023-05-15T14:01:45+02:00 Differential plague-transmission dynamics determine Yersinia pestis population genetic structure on local, regional, and global scales Girard, Jessica M. Wagner, David M. Vogler, Amy J. Keys, Christine Allender, Christopher J. Drickamer, Lee C. Keim, Paul 2004-06-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420407 http://www.ncbi.nlm.nih.gov/pubmed/15173603 https://doi.org/10.1073/pnas.0401561101 en eng National Academy of Sciences http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420407 http://www.ncbi.nlm.nih.gov/pubmed/15173603 http://dx.doi.org/10.1073/pnas.0401561101 Copyright © 2004, The National Academy of Sciences Biological Sciences Text 2004 ftpubmed https://doi.org/10.1073/pnas.0401561101 2013-08-29T23:40:46Z Plague, the disease caused by the bacterium Yersinia pestis, has greatly impacted human civilization. Y. pestis is a successful global pathogen, with active foci on all continents except Australia and Antarctica. Because the Y. pestis genome is highly monomorphic, previous attempts to characterize the population genetic structure within a single focus have been largely unsuccessful. Here we report that highly mutable marker loci allow determination of Y. pestis population genetic structure and tracking of transmission patterns at two spatial scales within a single focus. In addition, we found that in vitro mutation rates for these loci are similar to those observed in vivo, which allowed us to develop a mutation-rate-based model to examine transmission mechanisms. Our model suggests there are two primary components of plague ecology: a rapid expansion phase for population growth and dispersal followed by a slower persistence phase. This pattern seems consistent across local, regional, and even global scales. Text Antarc* Antarctica PubMed Central (PMC) The ''Y'' ENVELOPE(-112.453,-112.453,57.591,57.591) Proceedings of the National Academy of Sciences 101 22 8408 8413 |
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Biological Sciences Girard, Jessica M. Wagner, David M. Vogler, Amy J. Keys, Christine Allender, Christopher J. Drickamer, Lee C. Keim, Paul Differential plague-transmission dynamics determine Yersinia pestis population genetic structure on local, regional, and global scales |
topic_facet |
Biological Sciences |
description |
Plague, the disease caused by the bacterium Yersinia pestis, has greatly impacted human civilization. Y. pestis is a successful global pathogen, with active foci on all continents except Australia and Antarctica. Because the Y. pestis genome is highly monomorphic, previous attempts to characterize the population genetic structure within a single focus have been largely unsuccessful. Here we report that highly mutable marker loci allow determination of Y. pestis population genetic structure and tracking of transmission patterns at two spatial scales within a single focus. In addition, we found that in vitro mutation rates for these loci are similar to those observed in vivo, which allowed us to develop a mutation-rate-based model to examine transmission mechanisms. Our model suggests there are two primary components of plague ecology: a rapid expansion phase for population growth and dispersal followed by a slower persistence phase. This pattern seems consistent across local, regional, and even global scales. |
format |
Text |
author |
Girard, Jessica M. Wagner, David M. Vogler, Amy J. Keys, Christine Allender, Christopher J. Drickamer, Lee C. Keim, Paul |
author_facet |
Girard, Jessica M. Wagner, David M. Vogler, Amy J. Keys, Christine Allender, Christopher J. Drickamer, Lee C. Keim, Paul |
author_sort |
Girard, Jessica M. |
title |
Differential plague-transmission dynamics determine Yersinia pestis population genetic structure on local, regional, and global scales |
title_short |
Differential plague-transmission dynamics determine Yersinia pestis population genetic structure on local, regional, and global scales |
title_full |
Differential plague-transmission dynamics determine Yersinia pestis population genetic structure on local, regional, and global scales |
title_fullStr |
Differential plague-transmission dynamics determine Yersinia pestis population genetic structure on local, regional, and global scales |
title_full_unstemmed |
Differential plague-transmission dynamics determine Yersinia pestis population genetic structure on local, regional, and global scales |
title_sort |
differential plague-transmission dynamics determine yersinia pestis population genetic structure on local, regional, and global scales |
publisher |
National Academy of Sciences |
publishDate |
2004 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420407 http://www.ncbi.nlm.nih.gov/pubmed/15173603 https://doi.org/10.1073/pnas.0401561101 |
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ENVELOPE(-112.453,-112.453,57.591,57.591) |
geographic |
The ''Y'' |
geographic_facet |
The ''Y'' |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420407 http://www.ncbi.nlm.nih.gov/pubmed/15173603 http://dx.doi.org/10.1073/pnas.0401561101 |
op_rights |
Copyright © 2004, The National Academy of Sciences |
op_doi |
https://doi.org/10.1073/pnas.0401561101 |
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Proceedings of the National Academy of Sciences |
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101 |
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22 |
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8408 |
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8413 |
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1766271787008524288 |