Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems
In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-buta...
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ftpubmed:oai:pubmedcentral.nih.gov:4200869 2023-05-15T13:50:36+02:00 Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems Kolmas, Joanna Sobczak, Marcin Olędzka, Ewa Nałęcz-Jawecki, Grzegorz Dębek, Cezary 2014-09-22 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200869 http://www.ncbi.nlm.nih.gov/pubmed/25247580 https://doi.org/10.3390/ijms150916831 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/25247580 http://dx.doi.org/10.3390/ijms150916831 © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). CC-BY Article Text 2014 ftpubmed https://doi.org/10.3390/ijms150916831 2014-10-19T01:14:54Z In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. Moreover, the PCL diols were synthesized by the ring-opening polymerization catalysed by the lipase from Candida antarctica. Next, composite drug delivery systems for clodronate were prepared. The mechanical properties of the obtained biomaterials were determined. The cytotoxicity of the synthesized polymers was tested. The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems. Text Antarc* Antarctica PubMed Central (PMC) International Journal of Molecular Sciences 15 9 16831 16847 |
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Article Kolmas, Joanna Sobczak, Marcin Olędzka, Ewa Nałęcz-Jawecki, Grzegorz Dębek, Cezary Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems |
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In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. Moreover, the PCL diols were synthesized by the ring-opening polymerization catalysed by the lipase from Candida antarctica. Next, composite drug delivery systems for clodronate were prepared. The mechanical properties of the obtained biomaterials were determined. The cytotoxicity of the synthesized polymers was tested. The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems. |
format |
Text |
author |
Kolmas, Joanna Sobczak, Marcin Olędzka, Ewa Nałęcz-Jawecki, Grzegorz Dębek, Cezary |
author_facet |
Kolmas, Joanna Sobczak, Marcin Olędzka, Ewa Nałęcz-Jawecki, Grzegorz Dębek, Cezary |
author_sort |
Kolmas, Joanna |
title |
Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems |
title_short |
Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems |
title_full |
Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems |
title_fullStr |
Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems |
title_full_unstemmed |
Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems |
title_sort |
synthesis, characterization and in vitro evaluation of new composite bisphosphonate delivery systems |
publisher |
MDPI |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200869 http://www.ncbi.nlm.nih.gov/pubmed/25247580 https://doi.org/10.3390/ijms150916831 |
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Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/25247580 http://dx.doi.org/10.3390/ijms150916831 |
op_rights |
© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/ijms150916831 |
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International Journal of Molecular Sciences |
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15 |
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9 |
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16831 |
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16847 |
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1766253754739326976 |