Linking the Developmental and Degenerative Theories of Schizophrenia: Association Between Infant Development and Adult Cognitive Decline
Neurodevelopmental and neurodegenerative theories may be viewed as incompatible accounts that compete to explain the pathogenesis of schizophrenia. However, it is possible that neurodevelopmental and neurodegenerative processes could both reflect common underlying causal mechanisms. We hypothesized...
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ftpubmed:oai:pubmedcentral.nih.gov:4193708 2023-05-15T17:42:31+02:00 Linking the Developmental and Degenerative Theories of Schizophrenia: Association Between Infant Development and Adult Cognitive Decline Kobayashi, Hiroyuki Isohanni, Matti Jääskeläinen, Erika Miettunen, Jouko Veijola, Juha Haapea, Marianne Järvelin, Marjo-Riitta Jones, Peter B. Murray, Graham K. 2014-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193708 http://www.ncbi.nlm.nih.gov/pubmed/24583905 https://doi.org/10.1093/schbul/sbu010 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/24583905 http://dx.doi.org/10.1093/schbul/sbu010 © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Regular Article Text 2014 ftpubmed https://doi.org/10.1093/schbul/sbu010 2014-10-26T00:04:23Z Neurodevelopmental and neurodegenerative theories may be viewed as incompatible accounts that compete to explain the pathogenesis of schizophrenia. However, it is possible that neurodevelopmental and neurodegenerative processes could both reflect common underlying causal mechanisms. We hypothesized that cognitive dysfunction would gradually deteriorate over time in schizophrenia and the degree of this deterioration in adulthood would be predicted by an infant measure of neurodevelopment. We aimed to examine the association between age of learning to stand in infancy and deterioration of cognitive function in adulthood. Participants were nonpsychotic control subjects (n = 76) and participants with schizophrenia (n = 36) drawn from the Northern Finland 1966 Birth Cohort study. The schizophrenia group showed greater deterioration in abstraction with memory than controls, but there were no differences between schizophrenia and controls in rate of change of other cognitive measures. Age of learning to stand in infancy significantly inversely predicted later deterioration of abstraction with memory in adult schizophrenia (later infant development linked to greater subsequent cognitive deterioration during adulthood), possibly suggesting a link between abnormal neurodevelopmental and neurodegenerative processes in schizophrenia. Text Northern Finland PubMed Central (PMC) Schizophrenia Bulletin 40 6 1319 1327 |
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Regular Article Kobayashi, Hiroyuki Isohanni, Matti Jääskeläinen, Erika Miettunen, Jouko Veijola, Juha Haapea, Marianne Järvelin, Marjo-Riitta Jones, Peter B. Murray, Graham K. Linking the Developmental and Degenerative Theories of Schizophrenia: Association Between Infant Development and Adult Cognitive Decline |
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Regular Article |
description |
Neurodevelopmental and neurodegenerative theories may be viewed as incompatible accounts that compete to explain the pathogenesis of schizophrenia. However, it is possible that neurodevelopmental and neurodegenerative processes could both reflect common underlying causal mechanisms. We hypothesized that cognitive dysfunction would gradually deteriorate over time in schizophrenia and the degree of this deterioration in adulthood would be predicted by an infant measure of neurodevelopment. We aimed to examine the association between age of learning to stand in infancy and deterioration of cognitive function in adulthood. Participants were nonpsychotic control subjects (n = 76) and participants with schizophrenia (n = 36) drawn from the Northern Finland 1966 Birth Cohort study. The schizophrenia group showed greater deterioration in abstraction with memory than controls, but there were no differences between schizophrenia and controls in rate of change of other cognitive measures. Age of learning to stand in infancy significantly inversely predicted later deterioration of abstraction with memory in adult schizophrenia (later infant development linked to greater subsequent cognitive deterioration during adulthood), possibly suggesting a link between abnormal neurodevelopmental and neurodegenerative processes in schizophrenia. |
format |
Text |
author |
Kobayashi, Hiroyuki Isohanni, Matti Jääskeläinen, Erika Miettunen, Jouko Veijola, Juha Haapea, Marianne Järvelin, Marjo-Riitta Jones, Peter B. Murray, Graham K. |
author_facet |
Kobayashi, Hiroyuki Isohanni, Matti Jääskeläinen, Erika Miettunen, Jouko Veijola, Juha Haapea, Marianne Järvelin, Marjo-Riitta Jones, Peter B. Murray, Graham K. |
author_sort |
Kobayashi, Hiroyuki |
title |
Linking the Developmental and Degenerative Theories of Schizophrenia: Association Between Infant Development and Adult Cognitive Decline |
title_short |
Linking the Developmental and Degenerative Theories of Schizophrenia: Association Between Infant Development and Adult Cognitive Decline |
title_full |
Linking the Developmental and Degenerative Theories of Schizophrenia: Association Between Infant Development and Adult Cognitive Decline |
title_fullStr |
Linking the Developmental and Degenerative Theories of Schizophrenia: Association Between Infant Development and Adult Cognitive Decline |
title_full_unstemmed |
Linking the Developmental and Degenerative Theories of Schizophrenia: Association Between Infant Development and Adult Cognitive Decline |
title_sort |
linking the developmental and degenerative theories of schizophrenia: association between infant development and adult cognitive decline |
publisher |
Oxford University Press |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193708 http://www.ncbi.nlm.nih.gov/pubmed/24583905 https://doi.org/10.1093/schbul/sbu010 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/24583905 http://dx.doi.org/10.1093/schbul/sbu010 |
op_rights |
© The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
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CC-BY |
op_doi |
https://doi.org/10.1093/schbul/sbu010 |
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Schizophrenia Bulletin |
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40 |
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6 |
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1319 |
op_container_end_page |
1327 |
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1766144385647378432 |