Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria
The soft shell clam in many areas of the North Atlantic is afflicted with a fatal leukemia-like disease of unknown origin. Leukemic cells from the diseased animals were found to release reverse transcriptase and to express high RNA levels of a previously unknown member of the gypsy family of retroel...
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ftpubmed:oai:pubmedcentral.nih.gov:4191779 2023-05-15T17:31:28+02:00 Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria Arriagada, Gloria Metzger, Michael J. Muttray, Annette F. Sherry, James Reinisch, Carol Street, Craig Lipkin, W. Ian Goff, Stephen P. 2014-09-30 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191779 http://www.ncbi.nlm.nih.gov/pubmed/25201971 https://doi.org/10.1073/pnas.1409945111 en eng National Academy of Sciences http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/25201971 http://dx.doi.org/10.1073/pnas.1409945111 Biological Sciences Text 2014 ftpubmed https://doi.org/10.1073/pnas.1409945111 2015-04-05T00:06:30Z The soft shell clam in many areas of the North Atlantic is afflicted with a fatal leukemia-like disease of unknown origin. Leukemic cells from the diseased animals were found to release reverse transcriptase and to express high RNA levels of a previously unknown member of the gypsy family of retroelements, Steamer. The DNA copy number of the element was increased to enormously high levels in diseased cells, mediated by reverse transcription and integration into the host genome. The activation of Steamer expression and transposition may initiate or accelerate the course of leukemia and constitutes a potential diagnostic marker of the disease. Text North Atlantic PubMed Central (PMC) Proceedings of the National Academy of Sciences 111 39 14175 14180 |
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Biological Sciences |
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Biological Sciences Arriagada, Gloria Metzger, Michael J. Muttray, Annette F. Sherry, James Reinisch, Carol Street, Craig Lipkin, W. Ian Goff, Stephen P. Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria |
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Biological Sciences |
description |
The soft shell clam in many areas of the North Atlantic is afflicted with a fatal leukemia-like disease of unknown origin. Leukemic cells from the diseased animals were found to release reverse transcriptase and to express high RNA levels of a previously unknown member of the gypsy family of retroelements, Steamer. The DNA copy number of the element was increased to enormously high levels in diseased cells, mediated by reverse transcription and integration into the host genome. The activation of Steamer expression and transposition may initiate or accelerate the course of leukemia and constitutes a potential diagnostic marker of the disease. |
format |
Text |
author |
Arriagada, Gloria Metzger, Michael J. Muttray, Annette F. Sherry, James Reinisch, Carol Street, Craig Lipkin, W. Ian Goff, Stephen P. |
author_facet |
Arriagada, Gloria Metzger, Michael J. Muttray, Annette F. Sherry, James Reinisch, Carol Street, Craig Lipkin, W. Ian Goff, Stephen P. |
author_sort |
Arriagada, Gloria |
title |
Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria |
title_short |
Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria |
title_full |
Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria |
title_fullStr |
Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria |
title_full_unstemmed |
Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria |
title_sort |
activation of transcription and retrotransposition of a novel retroelement, steamer, in neoplastic hemocytes of the mollusk mya arenaria |
publisher |
National Academy of Sciences |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191779 http://www.ncbi.nlm.nih.gov/pubmed/25201971 https://doi.org/10.1073/pnas.1409945111 |
genre |
North Atlantic |
genre_facet |
North Atlantic |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/25201971 http://dx.doi.org/10.1073/pnas.1409945111 |
op_doi |
https://doi.org/10.1073/pnas.1409945111 |
container_title |
Proceedings of the National Academy of Sciences |
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111 |
container_issue |
39 |
container_start_page |
14175 |
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14180 |
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1766129080264032256 |