Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains

• Published in: Applied and Environmental Microbiology
• Main Authors: Weedmark, K. A., Lambert, D. L., Mabon, P., Hayden, K. L., Urfano, C. J., Leclair, D., Van Domselaar, G., Austin, J. W., Corbett, C. R.
• Format: Text
• Language: English
• Published: American Society for Microbiology 2014
• Subjects: Environmental Microbiology; Canada; Hudson; Hudson Bay; Koksoak River; Nunavik; Ungava Bay
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178653; http://www.ncbi.nlm.nih.gov/pubmed/25107978; https://doi.org/10.1128/AEM.01573-14

We sequenced 175 Clostridium botulinum type E strains isolated from food, clinical, and environmental sources from northern Canada and analyzed their botulinum neurotoxin (bont) coding sequences (CDSs). In addition to bont/E1 and bont/E3 variant types, neurotoxin sequence analysis identified two nov...