Frequent Loss and Alteration of the MOXD2 Gene in Catarrhines and Whales: A Possible Connection with the Evolution of Olfaction
The MOXD2 gene encodes a membrane-bound monooxygenase similar to dopamine-β-hydroxylase, and has been proposed to be associated with olfaction. In this study, we analyzed MOXD2 genes from 64 mammalian species, and identified loss-of-function mutations in apes (humans, Sumatran and Bornean orangutans...
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ftpubmed:oai:pubmedcentral.nih.gov:4125168 2023-05-15T15:37:08+02:00 Frequent Loss and Alteration of the MOXD2 Gene in Catarrhines and Whales: A Possible Connection with the Evolution of Olfaction Kim, Dong Seon Wang, Yao Oh, Hye Ji Lee, Kangseok Hahn, Yoonsoo 2014-08-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125168 http://www.ncbi.nlm.nih.gov/pubmed/25102179 https://doi.org/10.1371/journal.pone.0104085 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/25102179 http://dx.doi.org/10.1371/journal.pone.0104085 This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2014 ftpubmed https://doi.org/10.1371/journal.pone.0104085 2014-08-17T00:57:51Z The MOXD2 gene encodes a membrane-bound monooxygenase similar to dopamine-β-hydroxylase, and has been proposed to be associated with olfaction. In this study, we analyzed MOXD2 genes from 64 mammalian species, and identified loss-of-function mutations in apes (humans, Sumatran and Bornean orangutans, and five gibbon species from the four major gibbon genera), toothed whales (killer whales, bottlenose dolphins, finless porpoises, baijis, and sperm whales), and baleen whales (minke whales and fin whales). We also identified a shared 13-nt deletion in the last exon of Old World cercopithecine monkeys that results in conversion of a membrane-bound protein to a soluble form. We hypothesize that the frequent inactivation and alteration of MOXD2 genes in catarrhines and whales may be associated with the evolution of olfaction in these clades. Text baleen whales toothed whales PubMed Central (PMC) Gibbon ENVELOPE(-45.200,-45.200,-60.667,-60.667) PLoS ONE 9 8 e104085 |
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Research Article Kim, Dong Seon Wang, Yao Oh, Hye Ji Lee, Kangseok Hahn, Yoonsoo Frequent Loss and Alteration of the MOXD2 Gene in Catarrhines and Whales: A Possible Connection with the Evolution of Olfaction |
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Research Article |
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The MOXD2 gene encodes a membrane-bound monooxygenase similar to dopamine-β-hydroxylase, and has been proposed to be associated with olfaction. In this study, we analyzed MOXD2 genes from 64 mammalian species, and identified loss-of-function mutations in apes (humans, Sumatran and Bornean orangutans, and five gibbon species from the four major gibbon genera), toothed whales (killer whales, bottlenose dolphins, finless porpoises, baijis, and sperm whales), and baleen whales (minke whales and fin whales). We also identified a shared 13-nt deletion in the last exon of Old World cercopithecine monkeys that results in conversion of a membrane-bound protein to a soluble form. We hypothesize that the frequent inactivation and alteration of MOXD2 genes in catarrhines and whales may be associated with the evolution of olfaction in these clades. |
format |
Text |
author |
Kim, Dong Seon Wang, Yao Oh, Hye Ji Lee, Kangseok Hahn, Yoonsoo |
author_facet |
Kim, Dong Seon Wang, Yao Oh, Hye Ji Lee, Kangseok Hahn, Yoonsoo |
author_sort |
Kim, Dong Seon |
title |
Frequent Loss and Alteration of the MOXD2 Gene in Catarrhines and Whales: A Possible Connection with the Evolution of Olfaction |
title_short |
Frequent Loss and Alteration of the MOXD2 Gene in Catarrhines and Whales: A Possible Connection with the Evolution of Olfaction |
title_full |
Frequent Loss and Alteration of the MOXD2 Gene in Catarrhines and Whales: A Possible Connection with the Evolution of Olfaction |
title_fullStr |
Frequent Loss and Alteration of the MOXD2 Gene in Catarrhines and Whales: A Possible Connection with the Evolution of Olfaction |
title_full_unstemmed |
Frequent Loss and Alteration of the MOXD2 Gene in Catarrhines and Whales: A Possible Connection with the Evolution of Olfaction |
title_sort |
frequent loss and alteration of the moxd2 gene in catarrhines and whales: a possible connection with the evolution of olfaction |
publisher |
Public Library of Science |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125168 http://www.ncbi.nlm.nih.gov/pubmed/25102179 https://doi.org/10.1371/journal.pone.0104085 |
long_lat |
ENVELOPE(-45.200,-45.200,-60.667,-60.667) |
geographic |
Gibbon |
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Gibbon |
genre |
baleen whales toothed whales |
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baleen whales toothed whales |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/25102179 http://dx.doi.org/10.1371/journal.pone.0104085 |
op_rights |
This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0104085 |
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PLoS ONE |
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9 |
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e104085 |
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